Fc Receptors

doi:10.1007/978-3-319-07911-0

Cited by 14 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Antibody Characteristics That Impact Adcpmentioning

confidence: 99%

“…Additional regulation of Fc–Fc receptor interactions required for ADCP occurs via diversity in glycosylation of the antibody Fc (39). The IgG Fc region contains an N-linked glycan at asparagine 297 (Figure 1B) that impacts the conformation of the antibody and affinity for Fc receptors (39). As described in a comprehensive recent review by Jennewein and Alter, for IgG antibodies there are 36 possible glycoforms and 4 different subclasses, yielding a total of 144 possible unique Fc regions (40).…”

Section: Antibody Characteristics That Impact Adcpmentioning

confidence: 99%

“…Thus, Fcα-receptors, FcεRI, Fc receptor neonatal, Type II Fc receptors, and other Fc-binding proteins remain as native mouse forms. Moreover, repeated infusion of human IgG can result the development of anti-human IgG antibodies in these mice (195).…”

Section: Considerations For Translation Of Studies Performed In Animamentioning

confidence: 99%

See 2 more Smart Citations

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses

2019

View full text Add to dashboard Cite

Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody–antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. These Fc receptor-dependent antibody functions provide a direct link between the innate and adaptive immune systems by combining the potent antiviral activity of innate effector cells with the diversity and specificity of the adaptive humoral response. The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. In this review, we discuss the properties of Fc receptors, antibodies, and effector cells that influence ADCP. We also provide and interpret evidence from studies that support a potential role for ADCP in either inhibiting or enhancing viral infection. Finally, we describe current approaches used to measure antiviral ADCP and discuss considerations for the translation of studies performed in animal models. We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design.

show abstract

Section: Antibody Characteristics That Impact Adcpmentioning

confidence: 99%

Section: Antibody Characteristics That Impact Adcpmentioning

confidence: 99%

See 1 more Smart Citation

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses

2019

View full text Add to dashboard Cite

show abstract

“…In biopharmaceuticals, drug quality has been shown to depend on proper glycosylation (Hayes et al, 2014; Li and d’Anjou, 2009; Niwa and Satoh, 2015) since glycoforms of a recombinant protein can significantly impact drug half-life in the body (Sørensen et al, 2009), drug potency (Shields et al, 2002), inflammatory and immunological responses to therapeutics (Dalziel et al, 2014), and safety (Hermeling S et al, 2004; Van Beers and Bardor, 2012). The various ways in which glycans can influence a protein’s interactions with its environment make glycosylation a critical property to control in the production of recombinant proteins.…”

Section: Introductionmentioning

confidence: 99%

A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Spahn

Hansen

et al. 2016

Metabolic Engineering

View full text Add to dashboard Cite

Glycosylation is a critical quality attribute of most recombinant biotherapeutics. Consequently, drug development requires careful control of glycoforms to meet bioactivity and biosafety requirements. However, glycoengineering can be extraordinarily difficult given the complex reaction networks underlying glycosylation and the vast number of different glycans that can be synthesized in a host cell. Computational modeling offers an intriguing option to rationally guide glycoengineering, but the high parametric demands of current modeling approaches pose challenges to their application. Here we present a novel low-parameter approach to describe glycosylation using flux-balance and Markov chain modeling. The model recapitulates the biological complexity of glycosylation, but does not require user-provided kinetic information. We use this method to predict and experimentally validate glycoprofiles on EPO, IgG as well as the endogenous secretome following glycosyltransferase knock-out in different Chinese hamster ovary (CHO) cell lines. Our approach offers a flexible and user-friendly platform that can serve as a basis for powerful computational engineering efforts in mammalian cell factories for biopharmaceutical production.

show abstract

“…Immunoglobulin E (IgE)-mediated responses are associated with defense against helminths ( Gounni et al, 1994 ) and with allergy ( Tomassini et al, 1991 ). They are controlled by the high-affinity IgE receptor, FCER1, which is found on the surface of various immune effector cells, for example, mast cells, basophils, and eosinophils ( Daeron and Nimmerjahn, 2014 ). In humans, naturally occurring polymorphisms in FCER1 are known to affect an individual’s serum IgE levels, with consequences for their susceptibility to infection ( Weidinger et al, 2008 ; Granada et al, 2012 ) and their risk of developing inflammatory disease ( Hasegawa et al, 2003 ; Potaczek et al, 2006 ; Zhou et al, 2012 ; Niwa et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent

Wanelik

Begon

Bradley

et al. 2023

eLife

View full text Add to dashboard Cite

The genotype of an individual is an important predictor of their immune function, and subsequently, their ability to control or avoid infection and ultimately contribute offspring to the next generation. However, the same genotype, subjected to different intrinsic and/or extrinsic environments, can also result in different phenotypic outcomes, which can be missed in controlled laboratory studies. Natural wildlife populations, which capture both genotypic and environmental variability, provide an opportunity to more fully understand the phenotypic expression of genetic variation. We identified a synonymous polymorphism in the high-affinity Immunoglobulin E (IgE) receptor (GC and non-GC haplotypes) that has sex-dependent effects on immune gene expression, susceptibility to infection, and reproductive success of individuals in a natural population of field voles (Microtus agrestis). We found that the effect of the GC haplotype on the expression of immune genes differed between sexes. Regardless of sex, both pro-inflammatory and anti-inflammatory genes were more highly relatively expressed in individuals with the GC haplotype than individuals without the haplotype. However, males with the GC haplotype showed a stronger signal for pro-inflammatory genes, while females showed a stronger signal for anti-inflammatory genes. Furthermore, we found an effect of the GC haplotype on the probability of infection with a common microparasite, Babesia microti, in females – with females carrying the GC haplotype being more likely to be infected. Finally, we found an effect of the GC haplotype on reproductive success in males – with males carrying the GC haplotype having a lower reproductive success. This is a rare example of a polymorphism whose consequences we are able to follow across immunity, infection, and reproduction for both males and females in a natural population.

show abstract

Fc Receptors

Cited by 14 publications

References 14 publications

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses

A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent

Contact Info

Product

Resources

About