Fe2O3@SiO2@Eu-MOF@Tb-MOF Core/Multishell Nanoparticles for the Fluorescence Sensing of Aspirin and Acute Myocardial Infarction Biomarkers

Shi, Yang; Jiang, Yu; Wang, Xing Ze; Zhang, Zi Qing; Huo, Jian Zhong; Liu, Yuan Yuan; Wang, Xin Rui; Ding, Bin

doi:10.1021/acsanm.2c03688

Cited by 12 publications

(5 citation statements)

References 65 publications

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“…Another fluorescent MOF@nanoparticle composite sensor of aspirin was designed by Ding et al 131 In this study, the authors synthesized Fe 2 O 3 @SiO 2 @Eu-MOF@Tb-MOF (Mag-MOF) nanoballs which were utilized for the sensing of aspirin with a LOD of 0.43 μM. Quenching of the MOF's PL intensity was observed after injecting aspirin solution in an aqueous medium.…”

Section: Artemisinin (Atc)mentioning

confidence: 99%

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Ghosh,

Rana,

Biswas

2023

Chem. Mater.

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The surging growth of clinical and pharmaceutical medication as a consequence of population growth has become a threat to the environment. The inherent antagonistic effects of medications and their metabolized side products on a healthy society is an essential concern requiring immediate monitoring. To speculate on these environmental pollutants, a huge number of selective, sensitive, costeffective, and user-compatible metal−organic framework (MOF)-based fluorescent sensors have been reported by many prominent research groups. Many recent review articles cover the details of MOF-based florescence sensing of antibiotics, but an accumulation of MOF-based fluorometric detection of other pharmaceutical drugs is still not reported. Realizing this research gap, we have discussed most of the reported MOF sensors for various pharmaceutical drugs in this Review. The details of selectivity, sensitivity (limit of detection (LOD) and Stern−Volmer constant (K sv )), response time, and proposed mechanisms of drug sensing have been thoroughly discussed. Moreover, this article also covers the details of a few MOF-based antibiotic sensors, which have not been covered by any previous report. Therefore, this Review will provide valuable information and guidance to researchers to develop targeted fluorescent sensors for hazardous pharmaceutical drugs. Additionally, environmental science researchers can leverage this information to enhance their efforts to monitor and control environmental pollution.

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Section: Artemisinin (Atc)mentioning

confidence: 99%

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Ghosh,

Rana,

Biswas

2023

Chem. Mater.

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“…Ding et al established a fluorescent Fe 2 O 3 @SiO 2 @Eu-MOF@Tb-MOF (MagMOF) core/multishell nanomaterial sensing platform for the detection of AMI biomarkers CK-MB, CTn, and Mb. 184 The selectivity of AMI biomarkers was achieved by immobilizing the MagMOF core−shell with target NH 2 -mRNA, anti-CTn, and anti-Mb for selectively sensing of corresponding biomarkers such as CK-MB, CTn, and Mb as shown in Figure 7a(i−iii). A MagMOF core− shell fluorescent sensing system highly sensitive for CK-MB, CTn, and Mb was achieved with a lower detection limit of 174.98 U/L, 0.16 mg/L, and 0.94 mg/L respectively.…”

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

“…Magnetic core/multishell lanthanide MOF (Fe 2 O 3 @SiO 2 @Eu-MOF@Tb-MOF) nanomaterial sensing platform for acute myocardial infarction biomarkers (i) CK-MB, (ii) CTnI, and (iii) Mb. Reprinted with permission from ref . Copyright 2022 American Chemical Society.…”

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

“…Recently, many different fluorescent nanomaterials, such as metal nanoparticles (MNPs), core−shell nanoparticles, quantum dots (QDs), carbon dots (CDs), graphene/graphene oxides (GOs), semiconductor NPs, polymer NPs and MOFs, etc., have been used for fluorescence sensing of cardiac biomarkers. Ding et al established a fluorescent Fe 2 O 3 @SiO 2 @Eu-MOF@Tb-MOF (MagMOF) core/multishell nanomaterial sensing platform for the detection of AMI biomarkers CK-MB, CTn, and Mb 184. The selectivity of AMI biomarkers was achieved by immobilizing the MagMOF core−shell with target NH 2 -mRNA, anti-CTn, and anti-Mb for selectively sensing of corresponding biomarkers such as CK-MB, CTn, and Mb as shown in Figure7a(i−iii).…”

mentioning

confidence: 99%

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Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Vairaperumal,

Huang,

Liu

2023

ACS Appl. Bio Mater.

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Cardiovascular disease is a global health threat, and detecting cardiac biomarkers is essential for early-stage diagnosis and personalized treatment. Traditional approaches have limitations, but optical nanobiosensors offer rapid, highly selective, and sensitive detection. Optical nanobiosensors generate biosignals that transfer light signals while analytes bind with the bioreceptors. Optical nanobiosensors have advantages such as ease of monitoring, low cost, a wide detection range, and high sensitivity without any interference. An optical nanobiosensor platform is a promising approach for point-of-care cardiac biomarker detection with a low detection limit. This review mainly focuses on the detection of cardiovascular disease biomarkers based on various optical nanobiosensor approaches that have been reported during the last five years, and we have categorized them based on optical signal readouts. A detailed discussion of the classification of cardiovascular disease biomarkers, design strategies of optical biosensors, types of optically active nanomaterials, types of bioreceptors, functionalization techniques, various assay types, and sensing mechanisms is presented. Then, we summarize the optical signaling readout-based various nanobiosensors systems for the detection of cardiovascular disease biomarkers. Finally, we summarize and conclude with the recent development of point-of-care testing (PoCT) for cardiovascular disease biomarkers used in various optical readout techniques.

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“…With the increasing concern of human health problems and environmental pollution, coordination polymer (CPs), as a fluorescent chemical sensing material has been widely used because of their numerous advantages, such as simple operation, fast reaction, high sensitivity and selectivity, and low detection limit. , They have been successfully used as fluorescent probes to detect explosives, ions, , temperatures, biomarkers, gas, etc. In 2022, our team reported a lanthanide fluorescence CP [Tb 2 (adip)(bdc)(NMP) 4 ] (H 2 bdc = 1,4-dicarboxybenzene) as a single-emission “turn-on” fluorescence sensor for detecting aztreonam .…”

Section: Introductionmentioning

confidence: 99%

Coordination Polymer as a Self-Calibrated pH and Amikacin Luminescence Probe

Wang,

Li,

Tan

et al. 2023

Crystal Growth & Design

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By the solvothermal assembly of Gd(NO3)3·6H2O, H2dht (H2dht = 2,5-dihydroxyterephthalic acid), and H4adip (H4adip = 5,5′-(anthracene-9,10-diyl)diisophthalic acid), a luminescent coordination polymer (CP) [Gd(adip)1/2(dht)1/2(NMP)2] (1, NMP = N-methylpyrrolidone) has been prepared. 1 exhibits dual emission bands and has the fluorescence turn-on behavior toward pH and antibiotic amikacin (AMK). Therefore, 1 can serve as a luminescence turn-on self-calibrated sensing material to quantitatively detect pH value and AMK. In the pH range of 5.05–6.88, the sensitivity can reach 2296% per pH, which is the highest among all fluorescence pH sensors. 1 also shows excellent sensing properties for AMK, and a good linear relationship between the fluorescence intensity ratio and concentrations of AMK was observed with a slope of 1.2 × 105 M–1. The limit of detection (LOD) is 7.7 × 10–8 M. Meanwhile, 1 is also the first CP-based sensing material to detect AMK. In order to better understand the sensing phenomenon, we also discussed the sensing mechanism for pH and AMK in detail.

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Fe₂O₃@SiO₂@Eu-MOF@Tb-MOF Core/Multishell Nanoparticles for the Fluorescence Sensing of Aspirin and Acute Myocardial Infarction Biomarkers

Cited by 12 publications

References 65 publications

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Coordination Polymer as a Self-Calibrated pH and Amikacin Luminescence Probe

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