Feasibility analysis of an epidermal glucose sensor based on time-resolved fluorescence

Katika, Kamal M.; Pilon, Laurent

doi:10.1364/ao.46.003359

Cited by 6 publications

(8 citation statements)

References 45 publications

(71 reference statements)

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“…For example, development of methods to report blood glucose levels noninvasively has been the Holy Grail of diabetes-related studies. A recent report demonstrated the feasibility of using fluorescence lifetime of an implanted sensor for continuous measurement of glucose concentration in blood 502. Without doubt, noninvasive lifetime-based devices and methods will be developed in future.…”

Section: Fluorescence Lifetime Imaging Applicationsmentioning

confidence: 99%

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Fluorescence Lifetime Measurements and Biological Imaging

2010

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Section: Fluorescence Lifetime Imaging Applicationsmentioning

confidence: 99%

“…A recent report demonstrated the feasibility of using fluorescence lifetime of an implanted sensor for continuous measurement of glucose concentration in blood. 502 Without doubt, noninvasive lifetimebased devices and methods will be developed in future.…”

Section: Diabetes and Kidney Pathologiesmentioning

confidence: 99%

Fluorescence Lifetime Measurements and Biological Imaging

2010

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“…Furthermore, the reports of blood-borne infection have been noted with these invasive glucose sensors. For these reasons, new techniques have been employed to develop a minorly invasive and/or noninvasive device for blood glucose monitoring, including infrared (IR) spectroscopy, [3][4][5] fluorescence spectroscopy, [6][7] Raman spectroscopy, [8][9] optical polarization rotation measurement, [10][11][12][13] photoacoustic probes, 14 and surface plasmon resonance. [15][16] However, results from these techniques need to be checked frequently against direct blood glucose measurements, that is, they cannot replace the direct measure of a blood glucose sensor.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Diagnostic Devices for Diabetes through Measuring Tear Glucose

Zhang

Hodge

Hutnick

et al. 2011

J Diabetes Sci Technol

137

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This article reviews the development of a noninvasive diagnostic for diabetes by detecting ocular glucose. Early diagnosis and daily management are very important to diabetes patients to ensure a healthy life. Commercial blood glucose sensors have been used since the 1970s. Millions of diabetes patients have to prick their finger for a drop of blood 4-5 times a day to check blood glucose levels-almost 1800 times annually. There is a strong need to have a noninvasive device to help patients to manage the disease easily and painlessly. Instead of detecting the glucose in blood, monitoring the glucose level in other body fluids may provide a feasible approach for noninvasive diagnosis and diabetes control. Tear glucose has been studied for several decades. This article reviews studies on ocular glucose and its monitoring methods. Attempts to continuously monitor the concentration of tear glucose by using contact lens-based sensors are discussed as well as our current development of a nanostructured lens-based sensor for diabetes. This disposable biosensor for the detection of tear glucose may provide an alternative method to help patients manage the disease conveniently.

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“…The methods applied include infrared (IR) spectroscopy, , Raman spectroscopy, , optical coherence tomography, and measurement of tissue metabolic heat conformation; however, none are currently proven to be useful clinically . In addition, several in vivo sensing approaches have been proposed, including fluorescence spectroscopy, , surface plasmon resonance of nanoparticles, , electrical impedance measurements, and implantable/subcutaneous amperometric glucose sensors . Among these, only subcutaneous electrochemical glucose sensors are available commercially, although frequent calibration, short in vivo lifetimes, limited accuracy, and high cost have prevented their widespread use …”

mentioning

confidence: 99%

Evaluation of Commercial Glucometer Test Strips for Potential Measurement of Glucose in Tears

Jensen

Balijepalli

et al. 2014

Anal. Chem.

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Tear glucose measurements have been suggested as a potential alternative to blood glucose monitoring for diabetic patients. While previous work has reported that there is a correlation between blood and tear glucose levels in humans, this link has not been thoroughly established and additional clinical studies are needed. Herein, we evaluate the potential of using commercial blood glucose test strips to measure glucose in tears. Of several blood glucose strips evaluated, only one brand exhibits the low detection limit required for quantitating glucose in tears. Calibration of these strips in the range of 0-100 μM glucose with an applied potential of 150 mV to the working electrode yields a sensitivity of 0.127 nA/μM and a limit of quantitation (LOQ) of 9 μM. The strips also exhibit ≤13% error (n = 3) for 25, 50, and 75 μM glucose in the presence of 10 μM acetaminophen, 100 μM ascorbic acid, and 100 μM uric acid. Measurements of glucose in tears from nine normal (nondiabetic) fasting human subjects using strips yielded glucose values within the range of 5-148 μM (mean = 47 μM, median = 43 μM), similar to those for human tears reported by others with more complex LC-MS methods. The glucometer strip method could facilitate more clinical studies to determine whether tear glucose and blood glucose levels sufficiently correlate for application to routine measurements in tears to supplement blood glucose testing. This would be especially helpful for children, adolescents, other Type 1 diabetics, and also for Type 2 diabetics who require treatment with insulin and cannot tolerate multiple finger sticks per day.

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Feasibility analysis of an epidermal glucose sensor based on time-resolved fluorescence

Cited by 6 publications

References 45 publications

Fluorescence Lifetime Measurements and Biological Imaging

Fluorescence Lifetime Measurements and Biological Imaging

Noninvasive Diagnostic Devices for Diabetes through Measuring Tear Glucose

Evaluation of Commercial Glucometer Test Strips for Potential Measurement of Glucose in Tears

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