Feasibility of BNCT radiobiological experiments at the HYTHOR facility

Esposito, J.; Ceballos, C.; Soncin, Marina; Fabris, Clara; Friso, Elisabetta; Moro, Davide; Colautti, P.; Jori, Giulio; Rosi, G.; Nava, E.

doi:10.1016/j.nimb.2008.03.239

Cited by 8 publications

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“…In principle, both issues can be addressed by using a suitable imaging modality in vivo. This approach was proposed some years ago by Kabalka and co-workers [3] who used a 18 F derivative of borophenylalanine (BPA) with 18 F detection performed by using positron emission tomography (PET). This method Abstract: The upregulation of low-density lipoprotein (LDL) transporters in tumour cells has been exploited to deliver a sufficient amount of gadolinium/ boron/ligand (Gd/B/L) probes for neutron capture therapy, a binary chemioradiotherapy for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Neutron irradiation was carried out inside the thermal column of the TRIGA Mark II reactor at the University of Pavia. To significantly decrease the neutron dose absorbed by the liver and spleen, in which Gd/B/L-LDL adducts accumulate and to limit the neutron-induced radioactivity in the whole animal, the mouse body was protected using a neutron-absorber shield made of boric acid, [18] thus leaving only the tumour region exposed to the neutron flux (see Figure S1 in the Supporting Information). The irradiation plan was designed by using a simulation program dedicated to neutron and photon transport in complex geometries (MCNP).…”

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confidence: 99%

“…The irradiation plan was designed by using a simulation program dedicated to neutron and photon transport in complex geometries (MCNP). [18] The radiation/material interaction is carefully reproduced thanks to point-wise nuclear cross-section data. By starting from the concentration of 10 B atoms reported above and by using the MCNP calculation, the total dose (D tot ) absorbed by the tissues was calculated.…”

mentioning

confidence: 99%

“…A proper shield was designed to spare the healthy districts of the animal body involved in the neutron irradiation. By starting from the very similar test reported in reference [18], 99 % 10 B-enriched boric acid powder was chosen as the shield material and homemade shield units of 0.14 g cm À2 were suitably built (see Figures S1 and S2 in the Supporting Information). To design the irradiation plan and to optimise the shield the simulation code Monte Carlo N-Particles (MCNP), version 4c2 [19] was used (see Figure S2 in the Supporting information).…”

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MRI‐Guided Neutron Capture Therapy by Use of a Dual Gadolinium/Boron Agent Targeted at Tumour Cells through Upregulated Low‐Density Lipoprotein Transporters

Crich¹,

Alberti²,

Szabó³

et al. 2011

Chemistry A European J

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The upregulation of low-density lipoprotein (LDL) transporters in tumour cells has been exploited to deliver a sufficient amount of gadolinium/boron/ligand (Gd/B/L) probes for neutron capture therapy, a binary chemio-radiotherapy for cancer treatment. The Gd/B/L probe consists of a carborane unit (ten B atoms) bearing an aliphatic chain on one side (to bind LDL particles), and a Gd(III)/1,4,7,10-tetraazacyclododecane monoamide complex on the other (for detection by magnetic resonance imaging (MRI)). Up to 190 Gd/B/L probes were loaded per LDL particle. The uptake from tumour cells was initially assessed on cell cultures of human hepatoma (HepG2), murine melanoma (B16), and human glioblastoma (U87). The MRI assessment of the amount of Gd/B/L taken up by tumour cells was validated by inductively coupled plasma-mass-spectrometric measurements of the Gd and B content. Measurements were undertaken in vivo on mice bearing tumours in which B16 tumour cells were inoculated at the base of the neck. From the acquisition of magnetic resonance images, it was established that after 4-6 hours from the administration of the Gd/B/L-LDL particles (0.1 and 1 mmol kg(-1) of Gd and (10)B, respectively) the amount of boron taken up in the tumour region is above the threshold required for successful NCT treatment. After neutron irradiation, tumour growth was followed for 20 days by MRI. The group of treated mice showed markedly lower tumour growth with respect to the control group.

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