2018
DOI: 10.1016/j.neuroimage.2018.05.022
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Feasibility of imaging evoked activity throughout the rat brain using electrical impedance tomography

Abstract: A B S T R A C TElectrical Impedance Tomography (EIT) is an emerging technique which has been used to image evoked activity during whisker displacement in the cortex of an anaesthetised rat with a spatiotemporal resolution of 200 μm and 2 ms. The aim of this work was to extend EIT to image not only from the cortex but also from deeper structures active in somatosensory processing, specifically the ventral posterolateral (VPL) nucleus of the thalamus. The direct response in the cortex and VPL following 2 Hz fore… Show more

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Cited by 28 publications
(28 citation statements)
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“…The presented approach holds potential to image a variety of electroencephalographic seizure patterns, provided that the electrode arrangement for EIT current injection offers an adequate sensitivity for imaging in the region of interest. At present, the depth penetration of EIT with epicortical electrode arrays extends to the dorsal hippocampus ( Faulkner et al, 2018 ); this setup can therefore be used to image seizure activity throughout the cortex and in superficial hippocampal regions. The initial discharges within the seizure are of particular importance for localising the ictal onset zone; it would thus be desirable to specifically image the seizure onset pattern.…”
Section: Discussionmentioning
confidence: 99%
“…The presented approach holds potential to image a variety of electroencephalographic seizure patterns, provided that the electrode arrangement for EIT current injection offers an adequate sensitivity for imaging in the region of interest. At present, the depth penetration of EIT with epicortical electrode arrays extends to the dorsal hippocampus ( Faulkner et al, 2018 ); this setup can therefore be used to image seizure activity throughout the cortex and in superficial hippocampal regions. The initial discharges within the seizure are of particular importance for localising the ictal onset zone; it would thus be desirable to specifically image the seizure onset pattern.…”
Section: Discussionmentioning
confidence: 99%
“…It can also serve as a means to produce high-resolution tomographic images of activity in excitable neural tissue in brain and nerve with a millisecond and submillimeter resolution, "fast neural EIT." Our group has developed this for imaging neuronal depolarization in the brain during normal and epileptic activity with a resolution of 1 ms and <200 µm in the rat cerebral cortex 23,24 . The principle is that impedance in neuronal membranes falls as ion channels open during evoked activity 17 .…”
mentioning
confidence: 99%
“…Reducing the point spread function of the reconstruction would improve the localisation accuracy and shape estimation. This could be achieved through reconfiguration of the FPC to include internal electrodes [12]- [14] or a full grid [10], [15], [16] to better distribute the sensitivity across the plane of the electrodes. However, these may not sufficiently address the decrease in out of plane sensitivity towards the deformable contact surface.…”
Section: Discussionmentioning
confidence: 99%