Feasibility, Safety, and Efficacy of Percutaneous Transhepatic Injection of β-Cell Grafts

Maleux, Geert; Gillard, Pieter; Keymeulen, Bart; Pipeleers, Daniël; Ling, Zhidong; Heye, Sam; Thijs, Marleen; Mathieu, Chantal; Marchal, Guy

doi:10.1097/01.rvi.0000182506.88739.39

Cited by 25 publications

(16 citation statements)

References 19 publications

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“…In the present study no serious adverse event was recorded during or after any of the 37 transplantations, irrespective of whether the portal vein was reached by laparoscopy (22) or percutaneously (23). A transient rise in liver transaminases occurred between weeks 1 and 3 after the first implantation, as was also seen in previous studies (24,25), but this was not observed after the second one, suggesting a correlation with the start of immune suppressive drugs.…”

Section: Discussionsupporting

confidence: 55%

Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft

Keymeulen

Gillard

Mathieu

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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163

211

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Section: Discussionsupporting

confidence: 55%

Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft

Keymeulen

Gillard

Mathieu

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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163

211

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“…Different ways of delivering therapeutic agents into the pancreas have been described in rodent models [3, 8, 9] and large mammals, such as the dog [10] and the monkey [11]. Success of “in vivo” experimental pancreatic therapy largely depends on the use of an appropriate route of administration [2, 10].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas

Latorre

Hernández²,

Sun³

et al. 2011

Experimental Diabetes Research

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Objectives. To prospectively evaluate the technical feasibility and efficacy of wedged arterial injection (WAI) as a potential route for experimental selective therapy to the pancreas of healthy pigs. Materials and Methods. Selective angiographies were completed in ten pigs under general anaesthesia. By superselective angiography, the catheter was inserted and wedged into the major pancreatic artery, blocking the blood flow. In order to evaluate the efficacy of the WAI method, a DNA-specific fluorescent dye (Hoechst 33258) was used. Results. Histological study revealed a uniform distribution of the fluorescent dye within the nuclei of the endocrine and exocrine pancreatic cells. Pancreatic and liver enzymes as well as histopathology of the pancreas were normal. Conclusion. WAI is a highly effective minimally invasive methodology to target the porcine pancreas. The findings suggest that WAI may contribute to developing preclinical assays of pancreas gene or cell-transfer therapies in swine model.

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“…37 The process of intrahepatic infusion is currently considered safe, although there is a low risk of portal vein thrombosis and elevated portal pressures, in addition to bleeding from the percutaneous hepatic puncture site. [41][42][43][44] From a clinical viewpoint, BM seeding has the potential of being a less invasive, ambulatory procedure with almost unlimited opportunities for repeated implantation, as well as a low-risk, easy-access site for graft biopsies. This potential was recently confirmed by the clinical experience of direct intrabone cord-blood transplantation.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow as an alternative site for islet transplantation

Cantarelli¹,

Melzi²,

Mercalli³

et al. 2009

Blood

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The liver is the current site for pancreatic islet transplantation, but has many drawbacks due to immunologic and nonimmunologic factors. We asked whether pancreatic islets could be engrafted in the bone marrow (BM), an easily accessible and widely distributed transplant site that may lack the limitations seen in the liver. Syngeneic islets engrafted efficiently in the BM of C57BL/6 mice rendered diabetic by streptozocin treatment. For more than 1 year after transplantation, these animals showed parameters of glucose metabolism that were similar to those of nondiabetic mice. Islets in BM had a higher probability to reach euglycemia than islets in liver (2.4-fold increase, P ‫؍‬ .02), showed a compact morphology with a conserved ratio between ␣ and ␤ cells, and affected bone structure only very marginally. Islets in BM did not compromise hematopoietic activity, even when it was strongly induced in response to a BM aplasia-inducing infection with lymphocytic choriomeningitis virus.

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Feasibility, Safety, and Efficacy of Percutaneous Transhepatic Injection of β-Cell Grafts

Cited by 25 publications

References 19 publications

Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft

Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft

Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas

Bone marrow as an alternative site for islet transplantation

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