Features of patients with comorbid pathology treatment in internal medicine

Kuznetsova, L. F.; Bogoslav, T. V.; Reshetilov, Yu.I.; Bondar, M.V.

doi:10.14739/2310-1210.2015.5.53736

Cited by 2 publications

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“…The patients were also elderly (mean age 66.16±10.41 years) and the majority had comorbidity (93.8%). Most myocardial infarction researchers recognize that the presence of comorbid pathology can significantly negatively affect functional status and cardiovascular reserve [3][4][5]. These issues are often dealt with by cardiology departments in Ukraine and, accordingly, require specialized rehabilitation protocols.…”

Section: Resultsmentioning

confidence: 99%

“…Medical care for patients with coronary heart disease (CHD), including myocardial infarction, is often complicated by concomitant and combined pathology in these patients. restoration of health of the cardiologic patient, especially after acute coronary events, is complicated by the effect of one or more concomitant diseases and extremely difficult [3,4]. The problem is magnified by the fact that most research underpinning current treatment recommendations, including post-infarction patients, focuses on uncomplicated pathology.…”

Section: Introductionmentioning

confidence: 99%

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Estimation of functional reserves of the body and risk of cardiovascular events in patients with myocardial infarction with comorbid pathology undergoing rehabilitation

Levytska¹,

Швед²,

Корда³

2019

hpc

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Authors' contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane-analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Background. Cardiovascular diseases are the leading cause of death worldwide. In Ukraine, cardiovascular mortality is 66.7%. Material and methods. We examined 371 patients with myocardial infarction (MI) with comorbid pathology who had undergone 90 days of rehabilitation. We studied the possibility of quantitative estimation of comorbid pathology, the condition of functional reserves in patients with MI, their connection with clinical markers of reduced exercise tolerance and comorbidity index. Results. We established close correlations between the six-minute walk tests conducted on the 10 th , 30 th and 90 th days of rehabilitation (6MWT10, 6MWT30 and 6MWT90) with age of patients (r6MWT10 =-0.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estimation of functional reserves of the body and risk of cardiovascular events in patients with myocardial infarction with comorbid pathology undergoing rehabilitation

Levytska¹,

Швед²,

Корда³

2019

hpc

View full text Add to dashboard Cite

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“…Despite the well-established key risk factors for coronary heart disease (CHD), including smoking, arterial hypertension (AHT), obesity, dyslipidemia, physical inactivity, etc., the study of the role of other factors [2] and concomitant diseases [3] that can contribute to coronary artery disease (CAD) and the development and progression of heart failure (HF) of ischemic origin continues to be relevant. This includes, in particular, thyroid dysfunction [8,9,10,11], which ranks first among all…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Circadian Blood Pressure Profile in Patients With Acute Coronary Syndrome and Their Association With Thyroid Function

Kuz,

Solomenchuk

2023

AML

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The paper presents the results of a study of circadian arterial blood pressure (ABP) profile in patients with Acute Coronary Syndrome (ACS) and their association with thyroid-stimulating hormone (TSH) levels. Aim. To conduct a comparative analysis of circadian BP monitoring (CBPM) indicators in patients with ACS and their association with the TSH level. Materials and Methods. The study includes 125 patients with ACS aged 36 to 81 (mean age - 60.98± 0.81 years old). The patients were divided into two groups according to thyroid function. Group one (I) included 51 individuals (40.8%) - hypothyroid patients (TSH level>4mIU/ml), mean age - 62.51±1.18 years old; Group II included 74 individuals (59.2%) - euthyroid patients (TSH level 0.4-4mIU/ml), mean age - 59.93±1.08 years old. The serum-free thyroxine (FT4) levels were within the normal range in both groups. In the general group, the proportion of individuals with unstable angina (UA) was 28.8%, and with myocardial infarction (MI) - 71.2%. In particular, in Group I, the proportion of individuals with UA was 23.53%, and with MI - 76.47%; in Group II, the proportion of individuals with UA was 32.43%, and with MI - 67.57%, p>0,05 between Groups I and II. The circadian BP monitoring was carried out using the Biomed ВАТ41-2 device after stabilization of the patient's condition (on the second day of hospital admission). The following indicators have been determined: systolic BP (SBP) - daytime, nighttime, and average daily (24 hours) (SBPd, SBPn, and SBPav); diastolic BP (DBPd, DBPn, and DBPav); pulse BP (PBPd, PBPn, and PBPav); time index (TI) for SBPd, SBPn, and SBPav (SBPd TI, SBPn TI, and SBPav TI) and DBP (DBPd TI, DBPn TI, and DBPav TI); variability of SBPd, SBPn, and SBPav (SBPd var, SBPn var, and SBPav var) and DBP (DBPd var, DBPn var, and DBPav var); average daily index for SBP (SBP AvDI) and DBP (DBP AvDI); average daily heart rate (HRav). To study thyroid function in patients enrolled, TSH and FT4 levels were determined by chemiluminescent immunoassay method on the ARCHITECT iSystem analyzer using reagent kits for the quantitative determination of TSH (ARCHITECT TSH) and FT4 (ARCHITECT Free T4). Results and Discussion. The comparison of the CBPM results in both groups of patients with ACS shows significantly higher mean nighttime (SBPn and DBPn) levels in Group I patients compared to Group II patients: SBPn - by 6.27% (125.44±2.98 mm Hg (I) versus 117.58±2.26 (II), p<0,05), DBPn - by 6.15% (73.65±1.91 mm Hg (I) versus 69.12±1.62 (II), p<0,05), in the absence of a significant between-group difference between the mean levels of respective daytime and average daily indicators. Mean DBPn TI value also turned out to be significantly higher in Group I patients compared to Group II patients - by 33.69% (42.47±4.60% (I) versus 28.16±3.60% (II), p<0.01). Significant difference was detected between mean SBP AvDI and DBP AvDI indicators in hypothyroid patients (I) versus respective indicators in euthyroid patients (II): SBP AvDI (I) 2.52±1.25% versus SBP AvDI (II) 5.99±0.98, p<0.05; and DBP AvDI (I) 4.69±1.38% versus DBP AvDI (II) 8.88±1.32, p<0.05. Conclusions. 1. Mean nighttime BP indicator (SBPn, DBPn, and DBPn TI) levels were significantly higher in the Group of hypothyroid patients with ACS, compared to euthyroid patients. In addition, the proportion of patients whose mean nighttime SBP and DBP levels exceeded the permissible values (SBPn<120, DBPn<70 mm Hg) was significantly higher in the Group of hypothyroid patients (I) compared to the Group of euthyroid patients (II). 2. Every third hypothyroid patient (I) (SBP AvDI: 37.25% and DBP AvDI: 31.37%) had a night-peaker circadian BP profile, characterized by nighttime BP increase instead of reduction, which suggests an extremely unfavorable prognosis. The findings may signal an additional adverse effect of thyroid dysfunction on arterial tone and, accordingly, BP regulation, which brings about a high risk of complications of ACS.

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Features of patients with comorbid pathology treatment in internal medicine

Cited by 2 publications

References 0 publications

Estimation of functional reserves of the body and risk of cardiovascular events in patients with myocardial infarction with comorbid pathology undergoing rehabilitation

Estimation of functional reserves of the body and risk of cardiovascular events in patients with myocardial infarction with comorbid pathology undergoing rehabilitation

Characteristics of Circadian Blood Pressure Profile in Patients With Acute Coronary Syndrome and Their Association With Thyroid Function

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