Features of the Cytokine Status of Patients With Psoriasis Taking Into Account the Applied Treatment Methods

Abstract

The involvement of complex immune mechanisms in the pathological process in psoriasis actualizes immunological research, since the clinic and course of psoriasis largely depends on the degree of immunological disorders and the imbalance of cytokine regulation of intercellular interactions. The dynamics of these processes during sanogenesis is of some interest. The purpose of the work is to study the cytokine status and its changes in patients with psoriasis depending on the type of treatment. Materials and methods. Cytokine status (IL‑6, IL‑8, IL‑10, IFN-γ and TNF-α levels in blood sera) of 60 patients with psoriasis and 17 practically healthy individuals was determined using immunoenzymatic analysis. Results and discussion. According to the results of the study, a significant imbalance of the indicators of the cytokine status of patients with psoriasis was established, which is difficult to explain by the activation or suppression of any one-cytokine pathway. The obtained data indicate the need to take into account these indicators in the treatment of patients, especially with the use of immunosuppressive agents. Conclusions. When studying the cytokine status of patients with psoriasis before treatment, a significant increase in the production of pro-inflammatory cytokines IL‑6, IL‑8, TNF-α, IFN-γ and the anti-inflammatory cytokine IL‑10 by blood cells was found. The use of therapy methods, which in particular contained immunosuppressive drugs, led to a decrease in pro-inflammatory cytokines and a certain normalization of anti-inflammatory ones. At the same time, a tendency towards a lower effect of GCS on the normalization of cytokine status was noted in comparison with cytostatic drugs in comparison with therapy without immunosuppressive agents.