Fecal microbiota profile in atopic asthmatic adult patients

Okba, Ashraf Mahmoud; Saber, Sally; Abdel-Rehim, Asmaa S.M.; Amin, Mariam Maged; Mohamed, Dalia Abdel-Wahab

doi:10.23822/eurannaci.1764-1489.48

Cited by 13 publications

(17 citation statements)

References 51 publications

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“…This might be due to the complicated intestinal microbiome of adults, requiring consideration of diverse host factors, such as living environment and diet. Recently, the distinct gut microbiota has also been revealed in adult asthmatics 26,27 . Supporting this phenomenon, microbe-derived short-chain fatty acids were suggested as possible mediators in the pathogenesis of asthma 28 .…”

Section: Discussionmentioning

confidence: 99%

Metagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics

Lee

Choi

Yang³

et al. 2020

Sci Rep

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Different patterns of bacterial communities have been reported in the airways and gastrointestinal tract of asthmatics when compared to healthy controls. However, the blood microbiome of asthmatics is yet to be investigated. Therefore, we aimed to determine whether a distinct serum microbiome is observed in asthmatics by metagenomic analysis of serum extracellular vesicles (EVs). We obtained serum from 190 adults with asthma and 260 healthy controls, from which EVs were isolated and analyzed. The bacterial composition of asthmatics was significantly different from that of healthy controls. Chao 1 index was significantly higher in the asthma group, while Shannon and Simpson indices were higher in the control group. At the phylum level, Bacteroidetes was more abundant in asthmatics, while Actinobacter, Verrucomicrobia, and Cyanobacteria were more abundant in healthy controls. At the genus level, 24 bacterial genera showed differences in relative abundance between asthmatics and controls, with linear discriminant analysis scores greater than 3. Further, in a diagnostic model based on these differences, a high predictive value with a sensitivity of 0.92 and a specificity of 0.93 was observed. In conclusion, we demonstrated distinct blood microbiome in asthma indicating the role of microbiome as a potential diagnostic marker of asthma.

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Section: Discussionmentioning

confidence: 99%

Metagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics

Lee

Choi

Yang³

et al. 2020

Sci Rep

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“…Further studies on the fecal microbiota profile of adult atopic asthmatic patients revealed a positive association between Lactobacilli and Escherichia coli ( E . coli ) and atopic asthma as compared with healthy individuals 53 . In addition, another study revealed a negative association of Bifidobacterium adolescentis with long‐term asthma and a positive association of the Bifidobacterium adolescentis with total IgE levels in adult asthmatic patients 54 .…”

Section: Impact Of the Intestinal Microbiota On Allergymentioning

confidence: 95%

“…51 Further studies on the fecal microbiota profile of adult atopic asthmatic patients revealed a positive association between Lactobacilli and Escherichia coli (E. coli) and atopic asthma as compared with healthy individuals. 53 In addition, another study revealed a negative association of Bifidobacterium adolescentis with long-term asthma and a positive association of the Bifidobacterium adolescentis with total IgE levels in adult asthmatic patients. 54 In this respect, gut microbiome analysis in adults with allergic rhinitis compared with healthy controls demonstrated a reduction in αdiversity measured by the Shannon index with more abundance of Bacteroidota such as Parabacteroides and less abundance of phylum Firmicutes such as Coprococcus.…”

Section: Key Messagementioning

confidence: 97%

Impact of local human microbiota on the allergic diseases: Organ–organ interaction

Alhamwe

López

Zhernov

et al. 2023

Pediatric Allergy Immunology

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The homogeneous impact of local dysbiosis on the development of allergic diseases in the same organ has been thoroughly studied. However, much less is known about the heterogeneous influence of dysbiosis within one organ on allergic diseases in other organs. A comprehensive analysis of the current scientific literature revealed that most of the relevant publications focus on only three organs: gut, airways, and skin.Moreover, the interactions appear to be mainly unidirectional, that is, dysbiotic conditions of the gut being associated with allergic diseases of the airways and the skin.Similar to homogeneous interactions, early life appears to be not only a crucial period for the formation of the microbiota in one organ but also for the later development of allergic diseases in other organs. In particular, we were able to identify a number of specific bacterial and fungal species/genera in the intestine that were repeatedly associated in the literature with either increased or decreased allergic diseases of the skin, like atopic dermatitis, or the airways, like allergic rhinitis and asthma. The reported studies indicate that in addition to the composition of the microbiome, also the relative abundance of certain microbial species and the overall diversity are associated with allergic diseases of the corresponding organs. As anticipated for human association studies, the underlying mechanisms of the organ-organ crosstalk could not be clearly resolved yet. Thus, further work, in particular experimental animal studies How to cite this article: Alashkar Alhamwe B, López J-F, Zhernov Y, et al. Impact of local human microbiota on the allergic diseases: Organ-organ interaction.

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“…Several studies reinforce the concept that dysbiosis is heavily linked to allergic disease, especially asthma. Individuals with atopic asthma have significantly higher fecal levels of Lactobacillus and E. coli compared with healthy individuals [366]. In terms of microbiota metabolites, 12,13-diHOME (a relatively uncharacterized linoleic acid) is commonly found in neonates at high risk for asthma [367].…”

Section: Allergic Diseasesmentioning

confidence: 99%

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

et al. 2023

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Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. Herein, we review the most recent research advancements in the gut microbiota–immune axis. We discuss in detail how the gut microbiota is a tipping point for neonatal immune development as indicated by newly uncovered phenomenon, such as maternal imprinting, in utero intestinal metabolome, and weaning reaction. We describe how the gut microbiota shapes both innate and adaptive immunity with emphasis on the metabolites short-chain fatty acids and secondary bile acids. We also comprehensively delineate how disruption in the microbiota–immune axis results in immune-mediated diseases, such as gastrointestinal infections, inflammatory bowel diseases, cardiometabolic disorders (e.g., cardiovascular diseases, diabetes, and hypertension), autoimmunity (e.g., rheumatoid arthritis), hypersensitivity (e.g., asthma and allergies), psychological disorders (e.g., anxiety), and cancer (e.g., colorectal and hepatic). We further encompass the role of fecal microbiota transplantation, probiotics, prebiotics, and dietary polyphenols in reshaping the gut microbiota and their therapeutic potential. Continuing, we examine how the gut microbiota modulates immune therapies, including immune checkpoint inhibitors, JAK inhibitors, and anti-TNF therapies. We lastly mention the current challenges in metagenomics, germ-free models, and microbiota recapitulation to a achieve fundamental understanding for how gut microbiota regulates immunity. Altogether, this review proposes improving immunotherapy efficacy from the perspective of microbiome-targeted interventions.

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Fecal microbiota profile in atopic asthmatic adult patients

Cited by 13 publications

References 51 publications

Metagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics

Metagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics

Impact of local human microbiota on the allergic diseases: Organ–organ interaction

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

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