Fecal Microbiota Transplantation in Children

Giorgio, Valentina; Blasi, Elisa; Cammarota, Giovanni

doi:10.1007/978-3-030-80068-0_52

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2023

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“…In pediatric patients with recurrent CDI, the safety and effectiveness of FMT can be ensured by a thorough analysis of the effect on the gut microbiota [ 20 ]. A series of studies show the beneficial effects of fecal transplantation in children [ 21 , 22 ], but the technical aspects (quantity, delivery method, donor screening protocols, etc.) require more attention [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia—A Literature Review

Boicean,

Bratu,

Bacila

et al. 2023

Pathogens

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In a mutually beneficial connection with its host, the gut microbiota affects the host’s nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types of disease and gut dysbiosis or specific microorganisms. Fecal microbiota transplantation (FMT) is strongly advised for the treatment of recurrent or resistant Clostridium difficile infection (CDI) due to its outstanding clinical effectiveness against CDI. The therapeutic potential of FMT for other disorders, particularly inflammatory bowel diseases and malignancies, is currently gaining more and more attention. We summarized the most recent preclinical and clinical evidence to show the promise of FMT in the management of cancer as well as complications related to cancer treatment after reviewing the most recent research on the gut microbiota and its relationship to cancer.

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