Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency

Naruse, Satoru; Ishiguro, Hiroshi; Ko, Shigeru B. H.; Yoshikawa, Toshiyuki; Yamamoto, Takeshi; Yamamoto, Akiko; Futakuchi, Sachiko; Goto, Hidemi; Saitō, Yukio; Takahashi, Susumu

doi:10.1007/s00535-006-1884-0

Cited by 66 publications

(48 citation statements)

References 27 publications

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“…they are not diagnostic [105,106]. Conversely, tubeless tests of pancreatic function can detect severe exocrine insufficiency only [107][108][109]. An endoscopic pancreatic test has recently been proposed as an alternative tool [110,111].…”

Section: C7mentioning

confidence: 99%

Italian consensus guidelines for chronic pancreatitis

Frulloni

Falconi

Gabbrielli

et al. 2010

Digestive and Liver Disease

166

112

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This paper gives practical guidelines for diagnosis and treatment of chronic pancreatitis. Statements have been elaborated by working teams of experts, by searching for and analysing the literature, and submitted to a consensus process by using a Delphi modified procedure. The statements report recommendations on clinical and nutritional approach, assessment of pancreatic function, treatment of exocrine pancreatic failure and of secondary diabetes, treatment of pain and prevention of painful relapses. Moreover, the role of endoscopy in approaching pancreatic pain, pancreatic stones, duct narrowing and dilation, and complications was considered. Recommendations for most appropriate use of various imaging techniques and of ultrasound endoscopy are reported. Finally, a group of recommendations are addressed to the surgical treatment, with definition of right indications, timing, most appropriate procedures and techniques in different clinical conditions and targets, and clinical and functional outcomes following surgery. © 2010 Editrice Gastroenterologica Italiana S.r.l

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Section: C7mentioning

confidence: 99%

Italian consensus guidelines for chronic pancreatitis

Frulloni

Falconi

Gabbrielli

et al. 2010

Digestive and Liver Disease

166

112

View full text Add to dashboard Cite

show abstract

“…FE-1 is well documented in quantitative studies to be stable during intestinal transit and studies demonstrate significant correlation between fecal elastase and levels of other pancreatic enzymes such as duodenal lipase, amylase, trypsin, and bicarbonate concentration [2][3][4][5][6]. Fecal elastase is concentrated in human feces compared with pancreatic juice and is a simple, non-invasive and inexpensive test [2,7,8]. As a result, FE-1 has replaced ''tube tests'' and fecal fat measurement in most centers and has become the sole arbiter of pancreatic insufficiency for many.…”

mentioning

confidence: 99%

“…Fecal elastase has also been shown to be a useful screening tool for children with primary pancreatic disorders, especially in cystic fibrosis, and in this setting has been well validated [3]. It is widely accepted however that FE-1 is not helpful in the diagnosis of mild to moderate exocrine pancreatic insufficiency with a low sensitivity 0-65% [4,5,7]. In addition, in both adults and children, FE-1 has been shown to be non-specific in differentiating non-pancreatic malabsorption from pancreatic malabsorption [12].…”

mentioning

confidence: 99%

Fecal Elastase: A Useful Test for Pancreatic Insufficiency?

Tod

Fine

2010

Dig Dis Sci

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“…Various other clinical (Body weight, nutritional status, frequency of bowel movements, stool character, abdominal pain, global disease symptom score, quality of life score) as well as laboratory indicators (fecal elastase, fecal chymotrypsin, etc) may be used to test adequacy of PES in various studies. Of the laboratory tests, fecal elastase is a useful non-invasive test for detection of PEI, [110][111][112] but its usefulness in evaluating treatment compliance with PES has not been described.…”

Section: Dovepressmentioning

confidence: 99%