Feed intake regulation for the female broiler breeder: In theory and in practice ,

Richards, Mark; Rosebrough, R. W.; Coon, C. N.; McMurtry, J. P.

doi:10.3382/japr.2010-00167

Cited by 71 publications

(52 citation statements)

References 35 publications

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“…AMPK also plays a role in processes related to feed intake (Xue & Kahn, 2006). AMPK activation may occur due to environmental and metabolic stress, which can inhibit ATP synthesis or accelerate the use of ATP, causing an increase in the ratio of intracellular AMP: ATP (Richards et al, 2010). LKB1, also known as serine/threonine kinase 11 (STK11), is a heterotrimeric complex with two accessory proteins (Boudeau et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…These three units together form a biological unit that phosphorylates and activates AMPK (Towler & Hardie, 2007). According to Richards et al (2010), AMPK, a conserved energy sensor, when activated in the hypothalamus by metabolic and environmental stresses that deplete cells of energy, can stimulate catabolic pathways in an attempt to restore the amount of energy available to the animal organism. Our results also confirm the functional relationship between LKB1 and AMPK in birds (Proszkowiec-Weglarz et al, 2006) and suggest that males have a more efficient physiological mechanism of protection against ATP depletion by LKB1 and AMPK action than females.…”

Section: Resultsmentioning

confidence: 99%

“…The control of voluntary feed intake by animals involves a series of mechanisms that operate at the intersection of the central nervous system and the peripheral tissues of the body (Richards et al, 2010). These mechanisms can be influenced by several factors, including gender and ambient temperature (Ferket & Gernat, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Short communication: Gender and heat stress effects on hypothalamic gene expression and feed intake in broilers

Khatlab¹,

Vesco²,

Goes³

et al. 2018

Span. j. agric. res.

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Our study aims to evaluate gender and heat stress effects on animal performance and on the expression of five hypothalamic genes related to feed consumption: neuropeptide Y (NPY), ghrelin (GHRL), pro-opiomelanocortin (POMC), AMP-activated protein kinase (AMPKα-1), and liver kinase B1 (LKB1). To assay these effects, 42-day-old male and female broilers were maintained in thermal comfort or were subjected to heat stress (HS, 38°C for 24 hours). All animals were fed with diets formulated to meet their nutritional requirements. Broilers subjected to HS showed lower weight gain (p=0.0065) and tended to have lower feed intake (p=0.0687) than broilers kept in comfortable conditions. We observed gender and heat stress interaction effects on NPY (p=0.0225), AMPKα-1 (p=0.0398), and POMC expression (p=0.0072). The highest NPY gene expression was observed in male broilers from the thermal comfort group. Male broilers exposed to HS showed the highest AMPKα-1 gene expression levels. Comparing POMC expression between males and females at the comfortable temperature, we observed that females showed higher POMC expression levels than male broilers. A gender effect was also observed on LKB1 and AMPKα-1 gene expression (p=0.0256 and p=0.0001, respectively); increased expression was observed in male broilers. Our results indicate that the expression of some hypothalamic genes related to food consumption may contribute to the observed differences in voluntary feed intake between animals of different gender exposed to different environmental conditions. Additional keywords: female broilers, Gallus gallus; orexigenic genes; anorexigenic genes; heat stress. Abbreviations used: AMP (adenosine monophosphate); AMPKα-1 (AMP-activated protein kinase); ARC (hypothalamic arcuate nucleus); ATP (adenosine triphosphate); CRH (corticotropin-releasing hormone); GHRL (ghrelin); HS (heat stress); LKB1 (liver kinase B1); MSH (α-, β and γ melanocyte-stimulating hormone); mTOR (rapamycin target protein); NPY (neuropeptide Y); POMC (proopiomelanocortin); STK11 (serine/threoninekinase11).Authors' contributions: Conceived and designed the experiments, and analyzed the data: EG, APDV and ASK. Wrote the paper: ASK, APDV, EG and MAMS. All authors performed experiments, read and approved the final manuscript.Citation: Khatlab, A. S.; Del Vesco, A. P.; Goes, E. R.; Neto, A. R. O.; Soares, M. A. M.; Gasparino, E. (2018). Short communication: Gender and heat stress effects on hypothalamic gene expression and feed intake in broilers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Short communication: Gender and heat stress effects on hypothalamic gene expression and feed intake in broilers

Khatlab¹,

Vesco²,

Goes³

et al. 2018

Span. j. agric. res.

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“…Metabolic pathways involved in protein deposition and in food intake control, among others, also play a key role in FE. Recent studies on muscle growth (Tesseraud et al, 2007;Zheng et al, 2011) and food intake control have shown that the body has cellular/molecular mechanisms within a single signaling pathway that function to connect peripheral tissues, where energy is used or stored, to the central nervous system, which regulates energy acquisition, by controlling the feed intake (Richards et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial gene expression in the liver and muscle of high and low feed efficiency Japanese quail layers subjected to different environmental temperatures

et al. 2014

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ABSTRACT. We evaluated the adenine nucleotide translocator (ANT) and cytochrome oxidase subunit III (COX III) mRNA expressions in the muscle and liver of Japanese quails presenting high and low feed efficiency (FE), and subjected them to three different environmental temperatures: comfort, heat stress (38°C), and cold stress (10°C). ANT mRNA expression was lower in the liver of heat-stressed animals. In the muscle, higher ANT and COX III mRNA expressions were observed in high-FE and cold-stressed animals. In the liver, much higher expression of COX III mRNA was observed in cold-stressed animals. These results suggest a possible correlation between the genes involved in energy production by the mitochondria and FE phenotypes, and that environmental temperature can affect the ANT and COX III mRNA Feed efficiency and mitochondrial gene expression expressions. Japanese quails presenting different FE levels respond differently to environmental stimuli.

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“…Genetic selection for growth parameters in broiler chickens resulted in breeder stock that tends to lack the ability to self-regulate feed intake [1][2][3] . This improvement in body-weight-for-age of modern broiler chickens, due to an increased growth rate and associated higher nutrient supply, is closely related with excessive fat deposition, metabolic, skeletal and reproductive disorders, and high mortality rates that eventually reduce the profitability of the poultry industry [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Potent Anti-Adipogenic Effect of Green Tea and Green Tea Extracts in Chicken

Kim¹,

Regassa²,

#³

et al. 2017

JDO

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This study was conducted to examine the effect of green tea on body, adipose tissue, and liver weights and adipose tissue weight to body weight ratio and the adipogenic differentiation and expression of adipogenic transcripts in chicken (Gallus gallus) preadipocytes. In experiment one, chicks were weighed and randomly assigned to a control diet (CTRL) and green tea treatment (GT 1%, w/w) for 38 days. In experiment 2, preadipocytes were isolated from 20 wk old chicken and treated with an adipogenic cocktail (DMIOA) containing 500 nM dexamethasone, 0.5 mM 3-isobutyl-1-methylxanthine, 20 µg/mL insulin, and 300 μM OA, DMIOA+30 µg of extract B, E, H, Mc, T, and W, respectively, for 48 h. Data were analysed using the General Liner Model procedure of the Statistics Analysis System (SAS) Institute version 9.4, and differences were considered significant at P < 0.05. Gene expression was measured using quantitative real-time PCR. GT 1% significantly reduced body (-9%; P = 0.0447), liver (-20%; P = 0.0206), and abdominal fat weight (-44%; P = 0.0055) compared with the control (CTRL) group (GT 0%). The abdominal fat/body weight ratio of green tea supplemented group (-36%; P = 0.0125) was also significantly lower than that of control group. In cell culture study, all green tea extracts inhibited C/EBPα and β mRNA expression compared to DMIOA. DMIOA+B, T, or W reduced mRNA expression of FABP4 by three-fold compared to DMIOA. Although all green tea extracts reduced adipocyte formation, T and W had the strongest anti-adipogenic effects. These results demonstrate that supplementation of green tea could be an effective strategy in the control of obesity in chickens.

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Feed intake regulation for the female broiler breeder: In theory and in practice ,

Cited by 71 publications

References 35 publications

Short communication: Gender and heat stress effects on hypothalamic gene expression and feed intake in broilers

Short communication: Gender and heat stress effects on hypothalamic gene expression and feed intake in broilers

Mitochondrial gene expression in the liver and muscle of high and low feed efficiency Japanese quail layers subjected to different environmental temperatures

Potent Anti-Adipogenic Effect of Green Tea and Green Tea Extracts in Chicken

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