Feed Restriction Significantly Alters Lipogenic Gene Expression in Broiler Breeder Chickens

Richards, Mark; Poch, Stephen M.; Coon, C. N.; Rosebrough, R. W.; Ashwell, C. M.; McMurtry, John P.

doi:10.1093/jn/133.3.707

Cited by 124 publications

(92 citation statements)

References 32 publications

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“…Moreover, the changes in protein levels of PPARg, FAS and ATGL were basically consistent with the changes in mRNA expression. It has been found that changes in feed intake had significant effects on genes expression in the animal for a long time (Richards et al, 2003;Sun et al, 2006). However, NDV infection has more quick and severe changes on gene expression in our study.…”

Section: Discussioncontrasting

confidence: 55%

Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus

Chao

Yang

et al. 2012

Animal

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Experiments were conducted to determine the effects of Newcastle disease on chicken fat metabolism. Thirty black-bone chickens were infected intraocularly with the Newcastle disease virus (NDV). Six birds were killed at 0, 12, 24, 48 and 72 h post infection, respectively. Results showed that the NDV infection decreased concentration of high-density lipoprotein cholesterol and increased concentrations of total cholesterol and low-density lipoprotein cholesterol in the plasma. Concentrations of triglycerides and free fatty acid were decreased after their initial increase. NDV infection also dramatically raised the activities of lipoprotein lipase (LPL), hepatic lipase and lipases in the serum. Furthermore, PCR results showed that the incipient infection up-regulated mRNA expression of LPL, adipose triglyceride lipase and nuclear factor peroxisome proliferator-activated receptor alpha (PPARα), but down-regulated them at later stage. Similarly, mRNA expression of fatty acid synthase, acetyl-CoA carboxylase and nuclear factor PPARγ, fatty acid transport protein 1 (FATP1), and 4(FATP4) decreased, whereas fatty acid translocase and fatty acid-binding protein increased initially. Data from Western blotting analysis showed that the changes in protein levels were consistent with mRNA expression. These results indicated that fat metabolism of the chicken was affected by the NDV infection. At the beginning of NDV infection, lipogenesis was inhibited, whereas lipolysis was strengthened. After lipolysis was strengthened, fat metabolism was found to be maximally depressed.

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Section: Discussioncontrasting

confidence: 55%

Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus

Chao

Yang

et al. 2012

Animal

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“…In birds, lipogenesis (the conversion of glucose to TGs) takes place primarily in the liver, whereas the adipocyte serves as the storage site for TGs (Cogburn et al, 2004). Hepatic lipogenesis plays a direct role in the accumulation of lipid in the avian adipocyte, and 80% to 85% of the FAs stored in adipose tissue are generated through lipogenesis in the liver or from the diet (Richards et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Microarray analysis of genes differentially expressed in the liver of lean and fat chickens

Wang

Zhang

et al. 2010

Animal

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Excessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understand the gene expression and its regulation in chicken liver, the gene expression profiles of liver at developmental stages of chicken (1 week, 4 weeks and 7 weeks of age) were investigated and differentially expressed genes between lean and fat chicken lines divergently selected for abdominal fat content for eight generations were screened. Our data indicated that 4 weeks of age was a very important stage on chicken liver lipogenesis compared to 1 week and 7 weeks of age, and the glycometabolism in chicken liver could be related to lipid metabolism and the difference of glycometabolism could be another potential reason for the fat and lean phenotype occurrence besides the difference of lipogenesis in chicken liver. Our result have established groundwork for further study of the basic genetic control of chicken obesity and will benefit chicken research communities as well as researches that use chicken as a model organism for developmental biology and human therapeutics.

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“…In fat tissues, glucose and other nutrients are converted into fatty acids by the FASregulated pathway (Richards et al, 2003). Therefore, overexpression of FAS would increase triglyceride deposition in the body, which may cause obesity (Richards et al, 2003;Matsubara et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues

Jiang¹,

Li²,

Yang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Evodiamine, the major alkaloid component isolated from the fruit of dried, unripened Evodia rutaecarpa Bentham, affects the plasma levels of cholecystokinin and various biological events such as gastric emptying and gastrointestinal transit; these effects of evodiamine were previously investigated in male rats. In this study, we aimed to investigate the effects of evodiamine on average daily weight gain, rectal temperature, and expressions of genes involved in lipid metabolism in liver and adipose tissues. Evodiamine was added as a supplement, comprising 0.02, 0.04, and 0.06% of the diet fed to mice for 1, 2, 3, and 4 weeks. Results showed that average daily weight gain and rectal temperature decreased significantly over time in a dosedependent manner. Evodiamine changed expressions of the peroxisome proliferator-activated receptor-g (PPARg) in mouse adipose and liver tissues in time-and dose-dependent manners. We found that evodiamine Long-term effects of evodiamine on lipid metabolism decreased mRNA expression of the sterol-regulatory element binding protein (SREBP-1c) and fatty acid synthase in adipose tissue. In addition, evodiamine increased expressions of hormone-sensitive lipase in both liver and adipose tissues. Interestingly, evodiamine increased the expression of triglyceride hydrolase only in adipose tissue. In conclusion, evodiamine could influence lipid metabolism through regulation of the expressions of its key genes, as well as reduce body heat and body weight.

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Feed Restriction Significantly Alters Lipogenic Gene Expression in Broiler Breeder Chickens

Cited by 124 publications

References 32 publications

Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus

Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus

Microarray analysis of genes differentially expressed in the liver of lean and fat chickens

Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues

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