Femtosecond laser-induced nanoporous layer for enhanced osteogenesis of titanium implants

Hao, Yue; Zou, Xianrui; Zheng, Shijian; Hu, Yazhou; Zhang, Shiliang; Liang, Chunyong; Zhou, Huan; Wang, Donghui; Wang, Hongshui; Yang, Lei; Li, Qiang

doi:10.1016/j.msec.2021.112247

Cited by 22 publications

(21 citation statements)

References 43 publications

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“…[15] While a recent study reported on the evaluation of fs laser-textured implants in vitro, their performance was compared to a smooth surface control rather than more clinically relevant, rougher surfaces. [11] This is in agreement with studies on surfaces textured with longer pulse duration lasers, which generally show that the textured surfaces outperform the smooth controls in terms of bone-implant contact. [48,49] However, when compared to rough surface controls, laser-textured implants have demonstrated either inferior performance in a rabbit model of osseointegration [50] or similar performance in a tibial model in sheep [51] and in rabbits, [52] suggesting that there is some disagreement in the performance of long pulse duration laser-textured implants.…”

Section: Biological Responsesupporting

confidence: 88%

“…[8,9] Recently, laser-texturing has shown the capacity to direct osteoblast attachment [10] and to improve the osseointegration potential of Ti implant surfaces in comparison to polished surfaces, with the caveat that their performance in comparison to rougher, more clinically relevant surfaces, is still unknown. [11] Lasertexturing offers the capacity to easily generate a wide range of micro-and nano-scale topographical features and patterns. [12] In particular, due to its short pulse duration, femtosecond (fs)In modern oral maxillofacial surgery, long-term implant stability is intrinsically linked to the quality of osseointegration.…”

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confidence: 99%

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Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Lackington

Schweizer

Khokhlova

et al. 2022

Adv Materials Inter

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Ideally, dental implants should achieve rapid and maintain long-term mechanical stability, which is determined primarily by their integration into the underlying supporting bone. [3] This osseointegration capacity can be markedly improved through modifications of key surface properties, including roughness, wettability, oxide layer thickness, and surface chemistry. [4][5][6] Currently, anodization, sandblasting and acid-etching are widely used, individually or in combination, to modify the surface properties of dental implants. However, not only are these methods inherently limited by their stochastic nature but they can also introduce surface contaminants, which require additional post-process cleaning steps that increase overall fabrication time and cost. [7] Laser-texturing has emerged as a promising alternative for the treatment of Ti implant surfaces, offering several advantages, including increased control, precision and reproducibility, while reducing processing time and costs. [8,9] Recently, laser-texturing has shown the capacity to direct osteoblast attachment [10] and to improve the osseointegration potential of Ti implant surfaces in comparison to polished surfaces, with the caveat that their performance in comparison to rougher, more clinically relevant surfaces, is still unknown. [11] Lasertexturing offers the capacity to easily generate a wide range of micro-and nano-scale topographical features and patterns. [12] In particular, due to its short pulse duration, femtosecond (fs)In modern oral maxillofacial surgery, long-term implant stability is intrinsically linked to the quality of osseointegration. While the osseointegration capacity of implants can be improved by modifying their surface properties, commonly used techniques, including sandblasting and acid etching, are stochastic processes offering virtually zero capacity to control the uniformity and reproducibility of micro-and nano-scale surface features. In this study, titanium-aluminiumvanadium (TiAlV) implant surfaces are modified using femtosecond (fs) lasertexturing, and its influence on physicochemical properties, on blood-implant interactions, and on the osseointegration potential is investigated in vitro. Lasertexturing enables the production of designer surfaces with micro-scale features defined in size and arrangement. While state of the art TiAlV surfaces prepared by sandblasting with biphasic calcium phosphate (BCP) show significant grain refinement at the near surface, fs laser-texturing preserves the grain size and enhances the microstrain and oxide layer thickness but also leads to 15% lower bulk fatigue in comparison to BCP treatment. Blood coagulation is similar on laser-textured and BCP surfaces, as is mineralization by human bone progenitor cells, albeit with a decreasing trend for laser-textured surfaces. Laser-texturing thus presents as a promising approach to create highly reproducible designer surfaces with biological performance comparable to state-of-the-art implants.

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Section: Biological Responsesupporting

confidence: 88%

mentioning

confidence: 99%

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Lackington

Schweizer

Khokhlova

et al. 2022

Adv Materials Inter

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“…Surface properties, such as wettability and elastic modulus/hardness, play vital roles in cell behavior because they influence the interaction between the cell membrane and the substrate surface. − For example, Arima and Iwata reported that the WCA between 40 and 60° was beneficial for cell adhesion, and Yao et al used femtosecond laser irradiation to lower the surface stiffness and elastic modulus of Ti, and the obtained surface was more beneficial for the proliferation and osteogenesis behaviors of rBMSCs. Furthermore, Sr is an essential element for human body and 99% of Sr deposits on the bone area (36–140 mg/kg) .…”

Section: Results and Discussionmentioning

confidence: 99%

Strontium-Containing Barium Titanate-Modified Titanium for Enhancement of Osteointegration

Zhou

Jian

Xie

et al. 2022

ACS Biomater. Sci. Eng.

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One of the major challenges for Ti-based implants is insufficient osteointegration, which might result in the loosening of the implant. In this study, we fabricated strontium (Sr)-containing barium titanate (BST) on the surface of Ti to improve the bioactivity for osteointegration enhancement. The introduction of Sr significantly reduced the crystallization time and improved crystallinity, which was proved by X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. Compared with Ti, the BST film showed greater wettability surface and lower elastic modulus and hardness. Furthermore, in synergy with the release of Sr ions, the BST film improved early adhesion and followed osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, the bone implantation experiment suggested that the BST film could significantly improve the in vivo osteogenesis and osteointegration capabilities of Ti implants. In summary, this study revealed that BST-modified Ti has potential application in bone repair.

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“…The osteogenic activity expressed by cell proliferation and differentiation was shown to be improved by the femtosecond laser, the effect attributed to reduced Young's modulus and the microhardness of titanium due to an appearance of voids on the subsurface layer, which originated from cavitation during conditions of high tensile stresses and temperatures [23]. The considerable absence of torque after osseointegration was observed for the titanium alloy treated using laser techniques [22].…”

Section: Introductionmentioning

confidence: 94%

Effect of Laser Treatment on Intrinsic Mechanical Stresses in Titanium and Some of Its Alloys

et al. 2023

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Laser surface treatment conducted at different power levels is an option to modify titanium bone implants to produce nano- and microtopography. However, such processing can lead to excess mechanical stress within the surface layer. This research aims to calculate the level of such residual stresses after the surface processing of Ti grade IV, Ti15Mo, and Ti6Al7Nb alloys with an Nd:YAG laser. Light and scanning electron microscopies (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffractometry (XRD), optical profilography, and nano-indentation tests were applied to characterize the surface zone. The laser processing resulted in a distinct surface pattern and the formation of remelted zones 66–126 µm thick, with roughness values ranging between 0.22 and 1.68 µm. The mechanical properties were weakly dependent on the material composition. The residual stresses caused by the laser treatment were moderate, always tensile, increasing with loading, and was the highest for the Ti15Mo alloy.

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Femtosecond laser-induced nanoporous layer for enhanced osteogenesis of titanium implants

Cited by 22 publications

References 43 publications

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Strontium-Containing Barium Titanate-Modified Titanium for Enhancement of Osteointegration

Effect of Laser Treatment on Intrinsic Mechanical Stresses in Titanium and Some of Its Alloys

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