Quranic education plays a very critical role in preparing human resources. The Quran interpretation programs in various tertiary institutions are one of the efforts to introduce students to the Quran. It is necessary to create a Quran learning system based on e-learning. This study aimed to discover elearning-based learning of the Quran interpretation in the Industrial Revolution 4.0 era at the Islamic boarding school, Pondok Hajah Nuriyah Shabran. This research is a qualitative study using library data. The result of this research showed that the existence of science could make the Quran more alive and meaningful since science has been able to prove the truth of the Quran. Learning Quran interpretation based on e-learning significantly increases learning motivation.