Ferret Hepatitis E Virus Infection in Japan

Li, Tiancheng; Yonemitsu, Kenzo; Terada, Yutaka; Takeda, Naokazu; Wakita, Takaji; Maeda, Ken

doi:10.7883/yoken.jjid.2014.169

Cited by 14 publications

(8 citation statements)

References 19 publications

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“…Orthohepevirus C is divided into HEV-C1, which has been isolated in several countries, including Germany, Australia, Belgium, Denmark, France, Italy, Spain, Switzerland, USA, Vietnam, Indonesia, China and Hong Kong ( Rattus spp. , greater bandicoot rat, Asian musk shrew) [38,39,79,80,81,82,83,84,85,86,87], and HEV-C2 (ferret [88,89], mink [40]).…”

Section: Taxonomymentioning

confidence: 99%

Genetic Variability and Evolution of Hepatitis E Virus

Primadharsini

Nagashima

Okamoto

2019

Viruses

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Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus. HEV can cause both acute and chronic hepatitis, with the latter usually occurring in immunocompromised patients. Modes of transmission range from the classic fecal–oral route or zoonotic route, to relatively recently recognized but increasingly common routes, such as via the transfusion of blood products or organ transplantation. Extrahepatic manifestations, such as neurological, kidney and hematological abnormalities, have been documented in some limited cases, typically in patients with immune suppression. HEV has demonstrated extensive genomic diversity and a variety of HEV strains have been identified worldwide from human populations as well as growing numbers of animal species. The genetic variability and constant evolution of HEV contribute to its physiopathogenesis and adaptation to new hosts. This review describes the recent classification of the Hepeviridae family, global genotype distribution, clinical significance of HEV genotype and genomic variability and evolution of HEV.

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Section: Taxonomymentioning

confidence: 99%

Genetic Variability and Evolution of Hepatitis E Virus

Primadharsini

Nagashima

Okamoto

2019

Viruses

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“…One of those is the ferret. A ferret strain of HEV was first described in the Netherlands in 2010 and now appears to be widespread around the world [111,146,147]. Ferret HEV is distinct from human HEV, shares the highest similarity with rat HEV, and is assigned to the Orthohepevirus C species [111].…”

Section: Other Small Animal Modelsmentioning

confidence: 99%

Animal Models for Hepatitis E Virus

Corneillie

Banda

Meuleman

2019

Viruses

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Hepatitis E virus (HEV) is an underdiagnosed pathogen with approximately 20 million infections each year and currently the most common cause of acute viral hepatitis. HEV was long considered to be confined to developing countries but there is increasing evidence that it is also a medical problem in the Western world. HEV that infects humans belongs to the Orthohepevirus A species of the Hepeviridae family. Novel HEV-like viruses have been observed in a variety of animals and some have been shown to be able to cross the species barrier, causing infection in humans. Several cell culture models for HEV have been established in the past years, but their efficiency is usually relatively low. With the circulation of this virus and related viruses in a variety of species, several different animal models have been developed. In this review, we give an overview of these animal models, indicate their main characteristics, and highlight how they may contribute to our understanding of the basic aspects of the viral life cycle and cross-species infection, the study of pathogenesis, and the evaluation of novel preventative and therapeutic strategies.

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“…Ferrets (M. putorius), which have long been used as an animal model of influenza virus infection, may also be valuable for the study of www.perspectivesinmedicine.org HEV infection. HEV was first detected in ferrets from the Netherlands in 2012 (Raj et al 2012), but since then many other ferret HEV strains have been identified in ferrets used as laboratory animals or kept as pets in the United States and Japan (Raj et al 2012;Yang et al 2013;Li et al 2015b). Ferret HEV is distinct from human HEV and is widespread among ferrets in Europe, the Americas, and Asia.…”

Section: Ferrets (Mustela Putorius)mentioning

confidence: 99%

Small Animal Models of Hepatitis E Virus Infection

Wakita

2018

Cold Spring Harb Perspect Med

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Novel hepeviruses have been recovered from many different animal species in recent years, increasing the diversity known to exist among the , which now include two genera, and Multiple viral genotypes in the species are able to replicate and cause acute hepatitis E in humans, and thus represent an important public health problem in industrialized as well as developing countries. Although hepatitis E virus (HEV) infections typically result in acute and self-limited hepatitis, immunocompromised and transplant patients are vulnerable to prolonged infections and to chronic hepatitis. Cell culture systems have been established for several HEV strains and offer new opportunities for the study of HEV biology. Similarly, a variety of new small animal models have been developed, using either nonhuman hepeviruses in their cognate hosts as surrogates for human HEV, or human HEV infection of immunodeficient mice with chimeric livers engrafted with human hepatocytes. These new models provide several advantages over previous nonhuman primate models of hepatitis E infection and will facilitate studies of pathogenicity, cross-species infection, mechanisms of virus replication, and vaccine and antiviral agent development. This article reviews the current understanding of small animal models for HEV.

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Ferret Hepatitis E Virus Infection in Japan

Cited by 14 publications

References 19 publications

Genetic Variability and Evolution of Hepatitis E Virus

Genetic Variability and Evolution of Hepatitis E Virus

Animal Models for Hepatitis E Virus

Small Animal Models of Hepatitis E Virus Infection

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