Fertility and pregnancy in Iranian thalassemia patients: An update on transfusion complications

Takhviji, Vahideh; Zibara, Kazem; Azarkeivan, Azita; Mehrvar, Nastaran; Mehrvar, N; Mezginejad, Fatemeh; Khosravi, Abbas

doi:10.1111/tme.12707

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…Genes HBB and HBD encode hemoglobin subunits β and δ. Their deficiency is associated with thalassemia, a contributing factor of poor reproductive potential in women (Takhviji et al, 2020). Human hemoglobin deficiency is consistent with hemoglobin underexpression in dogs (Yang X. et al, 2018) and domestic chickens (Fallahshahroudi et al, 2019) when compared with the most recent common ancestors for their wild counterparts (see Table 4).…”

Section: Resultsmentioning

confidence: 70%

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

et al. 2022

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One of the greatest achievements of genetics in the 20th century is D.K. Belyaev’s discovery of destabilizing selection during the domestication of animals and that this selection affects only gene expression regulation (not gene structure) and influences systems of neuroendocrine control of ontogenesis in a stressful environment. Among the experimental data generalized by Belyaev’s discovery, there are also findings about accelerated extinction of testes’ hormonal function and disrupted seasonality of reproduction of domesticated foxes in comparison with their wild congeners. To date, Belyaev’s discovery has already been repeatedly confirmed, for example, by independent observations during deer domestication, during the use of rats as laboratory animals, after the reintroduction of endangered species such as Przewalski’s horse, and during the creation of a Siberian reserve population of the Siberian grouse when it had reached an endangered status in natural habitats. A genome-wide comparison among humans, several domestic animals, and some of their wild congeners has given rise to the concept of self-domestication syndrome, which includes autism spectrum disorders. In our previous study, we created a bioinformatic model of human self-domestication syndrome using differentially expressed genes (DEGs; of domestic animals versus their wild congeners) orthologous to the human genes (mainly, nervous-system genes) whose changes in expression affect reproductive potential, i.e., growth of the number of humans in the absence of restrictions caused by limiting factors. Here, we applied this model to 68 human genes whose changes in expression alter the reproductive health of women and men and to 3080 DEGs of domestic versus wild animals. As a result, in domestic animals, we identified 16 and 4 DEGs, the expression changes of which are codirected with changes in the expression of the human orthologous genes decreasing and increasing human reproductive potential, respectively. The wild animals had 9 and 11 such DEGs, respectively. This difference between domestic and wild animals was significant according to Pearson’s χ2 test (p < 0.05) and Fisher’s exact test (p < 0.05). We discuss the results from the standpoint of restoration of endangered animal species whose natural habitats are subject to an anthropogenic impact.

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Section: Resultsmentioning

confidence: 70%

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

et al. 2022

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“…Human gene HBD produces hemoglobin subunit δ, a deficit of which (thalassemia) is clinically proven as a risk factor for auto-aggressive impulsiveness up to suicide [64], female subfertility [65], under-threshold IQ, and severe anxiety in children [66], as readers can see in Table 8. Actually, both suicide and IQ look like human-specific traits, which are biomedically studied mostly in human behavioral models based on animals [67,68] and are not common in the wild [56].…”

Section: Discussionmentioning

confidence: 99%

“…This finding fits the first principal component (PC1) explaining two-thirds (67%) of the differential-gene-expression variance during the domestication-related microevolution (Figures 3 and 4a). With this in mind, we suggest HBD as a candidate gene contributing to self-domestication syndrome, namely: low HBD expression might be regarded as what humans pay with health (e.g., higher risks of suicide [64], female subfertility [65], low IQ, and anxiety in children [66]) for the benefits received during evolution (e.g., the ability to build trust [69][70][71], prevention of injuries [72], and making adequate decisions under stress [74]).…”

Section: Discussionmentioning

confidence: 99%

“…Recently [ 57 , 58 ], an RNA-Seq data analysis was based on this oldest phylogeny concept [ 59 ] widely used elsewhere [ 60 , 61 , 62 , 63 ]. Let us look at these orthologous genes one by one and discuss effects of their expression changes on reproductive potential in humans as well as during divergence of domestic and wild animals from their most recent com-mon ancestor [ 24 , 25 , 28 , 29 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ] ( Table 8 ).…”

Section: Discussionmentioning

confidence: 99%

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Domestication Explains Two-Thirds of Differential-Gene-Expression Variance between Domestic and Wild Animals; The Remaining One-Third Reflects Intraspecific and Interspecific Variation

Chadaeva

Пономаренко

Kozhemyakina

et al. 2021

Animals

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Belyaev’s concept of destabilizing selection during domestication was a major achievement in the XX century. Its practical value has been realized in commercial colors of the domesticated fox that never occur in the wild and has been confirmed in a wide variety of pet breeds. Many human disease models involving animals allow to test drugs before human testing. Perhaps this is why investigators doing transcriptomic profiling of domestic versus wild animals have searched for breed-specific patterns. Here we sequenced hypothalamic transcriptomes of tame and aggressive rats, identified their differentially expressed genes (DEGs), and, for the first time, applied principal component analysis to compare them with all the known DEGs of domestic versus wild animals that we could find. Two principal components, PC1 and PC2, respectively explained 67% and 33% of differential-gene-expression variance (hereinafter: log2 value) between domestic and wild animals. PC1 corresponded to multiple orthologous DEGs supported by homologs; these DEGs kept the log2 value sign from species to species and from tissue to tissue (i.e., a common domestication pattern). PC2 represented stand-alone homologous DEG pairs reversing the log2 value sign from one species to another and from tissue to tissue (i.e., representing intraspecific and interspecific variation).

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“…Thalassemia affects women's fertility. Iron overload impairs the hypothalamic-pituitaryovarian axis, which explains why the concentration of ferritin inversely correlates with reproductive hormone concentrations in thalassemic women [136]. Takhviji et al thus suggested that iron chelation, especially during puberty, could be beneficial for patients with thalassemia to increase fertility [136].…”

Section: Thalassemiamentioning

confidence: 99%

Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences

et al. 2022

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Iron is required for energy production, DNA synthesis, and cell proliferation, mainly as a component of the prosthetic group in hemoproteins and as part of iron-sulfur clusters. Iron is also a critical component of hemoglobin and plays an important role in oxygen delivery. Imbalances in iron metabolism negatively affect these vital functions. As the crucial barrier between the fetus and the mother, the placenta plays a pivotal role in iron metabolism during pregnancy. Iron deficiency affects 1.2 billion individuals worldwide. Pregnant women are at high risk of developing or worsening iron deficiency. On the contrary, in frequent hemoglobin diseases, such as sickle-cell disease and thalassemia, iron overload is observed. Both iron deficiency and iron overload can affect neonatal development. This review aims to provide an update on our current knowledge on iron and heme metabolism in normal and pathological pregnancies. The main molecular actors in human placental iron metabolism are described, focusing on the impact of iron deficiency and hemoglobin diseases on the placenta, together with normal metabolism. Then, we discuss data concerning iron metabolism in frequent pathological pregnancies to complete the picture, focusing on the most frequent diseases.

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Fertility and pregnancy in Iranian thalassemia patients: An update on transfusion complications

Cited by 7 publications

References 27 publications

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

Domestication Explains Two-Thirds of Differential-Gene-Expression Variance between Domestic and Wild Animals; The Remaining One-Third Reflects Intraspecific and Interspecific Variation

Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences

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