Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences

Mégier, C.; Peoc’h, Katell; Puy, Vincent; Cordier, Anne-Gaël

doi:10.3390/metabo12020129

Cited by 22 publications

(15 citation statements)

References 163 publications

(205 reference statements)

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“…Adequate iron levels and metabolism is essential for the purposes of maternofetal wellbeing in pregnancy. In addition, it has been broadly established that the placenta is a major regulator of iron concentration and metabolism during this period [15]. Notwithstanding the fact that iron deficiency is relatively common in pregnancy, the opposite situation-i.e., iron overload-can also be potentially hazardous during this period.…”

Section: Introductionmentioning

confidence: 99%

The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis

et al. 2023

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Psychosis is a complex entity characterized by psychological, behavioral, and motor alterations resulting in a loss of contact with reality. Although it is not common, pregnancy can be a period in which a first episode of psychosis can manifest, entailing detrimental consequences for both the fetus and the mother. The pathophysiological basis and study of maternofetal wellbeing need to be further elucidated. Lipid peroxidation and ferroptosis are two phenomena that are tightly linked to the placental dysfunction commonly observed in different complications of pregnancy. In the present study, we aim to explore the histopathological and gene expression of different markers of lipid peroxidation and ferroptosis in the placentas of women who underwent a first episode of psychosis during their pregnancy (n = 22). The aim is to then compare them with healthy pregnant women (n = 20). In order to achieve this goal, iron deposits were studied using Prussian Blue staining. In addition, the protein/gene expression of a transferrin receptor (TFRC), as well as an acyl-CoA synthetase long-chain family member 4 (ACSL-4), arachidonate lipoxygenase-5 (ALOX-5), malondialdehyde (MDA), and glutathione peroxidase 4 (GPX4) were all analyzed through gene expression (RT-qPCR) and immunohistochemical procedures. Our results demonstrate an increased presence of iron deposits that are accompanied by a further expression of TFRC, ACSL-4, ALOX-5, MDA, and GPX4—all of which are observed in the placenta tissue of women who have suffered from a first episode of psychosis. Therefore, in our study, a histopathological increase in lipid peroxidation and ferroptosis markers in the affected women is suggested. However, further studies are needed in order to validate our results and to establish possible consequences for the reported alterations.

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Section: Introductionmentioning

confidence: 99%

The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis

et al. 2023

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“… 2 Iron deficiency is also observed among patients with restless leg syndrome and among women with a history of heavy menstrual bleeding or during the peripartum period. 3 , 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

“…Functional or absolute iron deficiency occurs frequently among patients with chronic kidney disease (CKD), cancer, and systemic inflammatory conditions, including inflammatory bowel disease 2 . Iron deficiency is also observed among patients with restless leg syndrome and among women with a history of heavy menstrual bleeding or during the peripartum period 3–5 …”

Section: Introductionmentioning

confidence: 99%

“…2 Iron deficiency is also observed among patients with restless leg syndrome and among women with a history of heavy menstrual bleeding or during the peripartum period. [3][4][5] Iron deficiency is also a common finding among patients with heart failure (HF). [6][7][8][9][10] The presence of iron deficiency in the setting of HF, independent of anaemia, is associated with adverse outcomes, including reduced exercise capacity, decreased quality of life, increased risk of hospitalization, and increased cardiovascular and all-cause mortality.…”

Section: Introductionmentioning

confidence: 99%

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Hypophosphataemia risk associated with ferric carboxymaltose in heart failure: A pooled analysis of clinical trials

2023

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Aims Iron deficiency is a common finding among patients with heart failure (HF) and is associated with adverse outcomes, including decreased quality of life, increased risk of hospitalization, and decreased survival. Intravenous ferric carboxymaltose (FCM) has been shown to improve outcomes among patients with HF and concomitant iron deficiency, but FCM is associated with an increased risk of hypophosphataemia. We aimed to better characterize this risk among HF populations. Methods and resultsThis pooled analysis examined data from 41 studies of adults with iron deficiency across disease states and therapeutic areas. Among the 7931 patients treated with FCM available for analysis, 14% made up the HF subgroup. Additional subgroups included women's health (36%), non-dialysis-dependent chronic kidney disease (NDD-CKD; 27%), haemodialysis-dependent chronic kidney disease (HD-CKD; 1%), gastrointestinal (10%), neurology (3%), and other (10%). The incidence of post-baseline moderate or severe hypophosphataemia (i.e. serum phosphate [PO 4 3À ] level <2.0 mg/dL) varied across the therapeutic areas, with the lowest incidences observed in the HD-CKD (0%), HF (8.1%), and NDD-CKD (12.8%) subgroups. The prevalence of moderate or severe hypophosphataemia among the women's health, other, gastrointestinal, and neurology subgroups was 30.1%, 40.6%, 51.0%, and 55.6%, respectively. In the HF subgroup, one patient (<0.1%) had a serum PO 4 3À of <1.0 mg/dL recorded, compared with 4.8% and 4.0% of the subjects in the neurology and gastrointestinal groups, respectively. With the exception of the HD-CKD subgroup, mean serum PO 4 3À levels decreased through weeks 2 to 4, and then returned toward baseline and plateaued by week 8. The strongest predictor of hypophosphataemia was preserved kidney function (estimated glomerular filtration rate: >60 mL/min/1.73 m 2 vs. <30 mL/min/1.73 m 2 ; odds ratio: 12.2). Among patients in the HF subgroup, the incidence of treatment-emergent adverse events potentially related to hypophosphataemia (e.g. cardiac failure, ventricular tachyarrhythmias, fatigue, muscle weakness, bone pain, neurological symptoms, and muscle pain) was lower among FCM-treated patients than among those receiving placebo, and lower among patients with a post-baseline PO 43À <2 mg/dL vs. those not meeting such criteria. Conclusions The risk of laboratory-assessed hypophosphataemia in HF patients treated with FCM was lower than that seen in patients in other therapeutic areas treated with FCM, and clinical events associated with hypophosphataemia are uncommon with FCM therapy in this population. Appropriate monitoring, particularly soon after administration, will allow for further refinement of management strategies.

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“…Studies have shown that anemia in pregnant women can affect the transport of iron to the fetus, reducing iron and hemoglobin levels. Iron and hemoglobin deficiencies can affect fetal brain development, slow fetal growth, and increase newborns' risk of health problems (Mégier et al, 2022). Agreed, pregnant women must ensure adequate iron levels and monitor their health during pregnancy (Hladunewich & Schatell, 2016).…”

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confidence: 99%

Uncovering the Determinants of Birth Weight: An Investigation on Pregnant Women in Makassar City

2023

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Birth weight is an essential indicator in assessing a baby's health and a factor that affects the baby's long-term health. This study aimed to determine the relationship between the Body Mass Index (BMI), Hemoglobin levels, and Blood Pressure of mothers during pregnancy and to birth weight of the baby. The study used a cross-sectional survey of a group of mothers who gave birth in Makassar. The data on mothers during pregnancy was the maternal history recorded in the mother and Child Health Book (KIA). And the data on the birth weight of the baby was also from the KIA book with the support of secondary data from the Community Health Center and Midwife. The results showed that 41.7% of the low-birth-weight babies had mothers who experienced underweight during pregnancy, 83.3% of the low-birth-weight babies had mothers who experienced Anemia during pregnancy, and 66.7% of the low-birth-weight babies had mothers who experienced hypertension during pregnancy. There was a significant and close relationship between the mother's BMI, Hemoglobin levels, and Blood Pressure to the baby's birth weight. There was a meaningful relationship between the mother's Body Mass Index, Anemia, and Hypertension during pregnancy to low birth weight. Therefore, it is important to maintain a good quality of nutrition for mothers both before and during pregnancy, following Islamic teachings that Allah SWT has decreed for every pregnant woman a thousand good deeds every day and erases a thousand misdeeds as motivation to remain strong throughout the pregnancy process.

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Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences

Cited by 22 publications

References 163 publications

The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis

The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis

Hypophosphataemia risk associated with ferric carboxymaltose in heart failure: A pooled analysis of clinical trials

Uncovering the Determinants of Birth Weight: An Investigation on Pregnant Women in Makassar City

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