Fetuin-A Is an Independent Predictor of Death after ST-Elevation Myocardial Infarction

Lim, Pascal; Collet, Jean-Phillipe; Moutereau, Stéphane; Guigui, N.; Mitchell-Heggs, Laurens; Loric, Sylvain; Bernard, M.; Benhamed, Said; Montalescot, Gilles; Randé, Jean-Luc Dubois; Guéret, Pascal

doi:10.1373/clinchem.2006.084947

Cited by 54 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, some clinical studies have indicated the opposite trends-a decrease in fetuin-A levels have been associated with the presence of PAD in diabetics, an increased arterial stiffness, atherosclerotic plaque calcification and progression of cardiovascular disease 14,48 . Contrary to some reports, many previous studies indicate that fetuin-A concentrations are decreased in patients with stable angina and acute myocardial infarction, this glycoprotein may be independent predictor of death after ST-elevation myocardial infarction and low levels of fetuin-A are correlated to the severity of coronary arterial calcification 49,50,51 . It should be mentioned that the renal function has influence on cardiovascular risk due to accelerated vascular calcifications aggravated by hyperphosphataemia and hypercalcaemia.…”

Section: Fetuin-a As a Marker Of Cardiovascular Diseasecontrasting

confidence: 90%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Dabrowska

Tarach

Wojtysiak-Duma

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Section: Fetuin-a As a Marker Of Cardiovascular Diseasecontrasting

confidence: 90%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Dabrowska

Tarach

Wojtysiak-Duma

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

“…Because higher fetuin-A concentrations may also induce peripheral insulin resistance, (41 ) it is possible that the mechanisms linking high fetuin-A with CVD events in the study by Weikert were through pathways distinct from arterial calcium deposition. In contrast, 2 other smaller studies have reported that lower fetuin-A concentrations measured in individuals with myocardial infarction were associated with greater mortality risk (42,43 ). Thus, future studies are required to determine the direction of association of fetuin-A with the incident development of CVD events in community-living individuals and to evaluate the extent to which factors such as arterial calcification and insulin resistance may mediate or modify the association.…”

Section: Fetuin-a Quartilementioning

confidence: 94%

Fetuin-A Is Inversely Associated with Coronary Artery Calcification in Community-Living Persons: The Multi-Ethnic Study of Atherosclerosis

Katz

Boer

et al. 2012

Clinical Chemistry

View full text Add to dashboard Cite

BACKGROUND Fetuin-A is a hepatic secretory protein that inhibits arterial calcification in vitro. The association of fetuin-A with coronary arterial calcification (CAC) in the general population is uncertain. METHODS Among 2457 community-living individuals without cardiovascular disease (CVD), we measured serum fetuin-A concentrations by ELISA and evaluated the cross-sectional association of fetuin-A with CAC prevalence (any vs none) and severity; on follow-up 3.2 years (median) later, we evaluated the association of fetuin-A with CAC incidence and progression. RESULTS The mean age was 62 (SD 10) years, and the mean fetuin-A concentration was 0.48 (0.10) g/L. At baseline, 1200 individuals (49%) had CAC, and 272 individuals developed CAC during follow-up. At baseline, there was a threshold effect at the lowest fetuin-A quartile with CAC prevalence. In models adjusted for demographics, traditional cardiovascular disease (CVD) risk factors and kidney function, the lowest fetuin-A quartile had 7% (95% CI 1%–13%; P = 0.04) greater CAC prevalence compared with quartiles 2–4. Similar associations were observed with CAC severity at baseline, but the association was more linear. Each SD (0.10 g/L) lower fetuin-A was associated with a 12% (95% CI 3%–21%; P = 0.01) greater CAC severity in adjusted models. There was no significant association of fetuin-A with CAC incidence or progression. CONCLUSIONS Fetuin-A is inversely associated with CAC severity among community-living individuals without CVD. Whether fetuin-A concentrations are associated with incident CVD event in the general population requires future study.

show abstract

“…Similarly, in a recent study, hs-CRP, which is a positive acute phase reactant, was associated with an increase in mortality in patients with ACS [36]. In another study of ACS, Lim et al [37] have demonstrated that low serum fetuin-A levels in patients with STEMI were associated with a poor prognosis. As determined in our study, the fetuin-A levels in patients with ACS, as an indicator of the severity of the inammatory response, are low and may indicate a poor prognosis.…”

Section: Discussionmentioning

confidence: 76%

Association of serum fetuin-A levels with heart valve calcification and other biomarkers of inflammation among persons with acute coronary syndrome

Afşar¹,

Uzun²,

Yurdakul³

et al. 2012

CIM

View full text Add to dashboard Cite

Association of serum fetuin-A levels with heart valve calci cation and other biomarkers of in ammation among persons with acute coronary syndrome Abstract Purpose: Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and valvular calci cation. Our aim was to evaluate the relationship among fetuin-A levels, heart valve calci cation and other biomarkers of in ammation in patients with acute coronary syndrome (ACS).Methods: e associations among serum fetuin-A concentrations, mitral annular (MAC) and aortic valve calci cation and other biomarkers of in ammation (hs-CRP, ferritin, -brinogen, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), albumin levels) were evaluated in ACS patients and healthy controls. e study included 95 patients (mean age 61.8±12.10 years) and 81 healthy controls (mean age 48.33±9.19 years).Results: Fetuin-A levels were signi cantly lower in patients with ACS than in healthy controls (0.76 ± 0.23 and 1.10 ± 0.45 g/L, respectively; p<0.001). Fetuin-A was lower in patients with mitral annular calci cation (p=0.007) and aortic (p=0.001) valve calci cation. In patients with ACS, there was a negative correlation among serum urea (r=-0.377; p<0.001) and creatinine (r=-0.232; p=0.024) levels and fetuin-A, and a negative correlation among WBC (r=-0.156; p=0,132), ESR (r=-0.214; p=0.037), hs-CRP (r=-0.220; p=0.032) levels and fetuin-A. A positive correlation was seen between albumin and fetuin-A (r=0.362; p<0.001). Multivariate logistic regression analysis revealed that fetuin-A was the variable that had a signi cant e ect on ACS (p = 0.020 OR = .015; (95% CI )(0.000-0.520).Conclusion: Fetuin-A levels decrease in patients with acute coronary syndromes, independent of heart valve calci cation. Fetuin-A may therefore act as a negative acute phase protein a er myocardial infarction.

show abstract

Fetuin-A Is an Independent Predictor of Death after ST-Elevation Myocardial Infarction

Cited by 54 publications

References 32 publications

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Fetuin-A Is Inversely Associated with Coronary Artery Calcification in Community-Living Persons: The Multi-Ethnic Study of Atherosclerosis

Association of serum fetuin-A levels with heart valve calcification and other biomarkers of inflammation among persons with acute coronary syndrome

Contact Info

Product

Resources

About