Fetus, as an allograft, evades the maternal immunity

Madani, Javad; Aghebati‐Maleki, Leili; Gharibeh, Nastaran; Pourakbari, Ramin; Yousefi, Mehdi

doi:10.1016/j.trim.2022.101728

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Cited by 3 publications

References 150 publications

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The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss

Ahmadi,

Soltani-Zangbar,

Yousefi

et al. 2024

Immunology Letters

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The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss

Ahmadi,

Soltani-Zangbar,

Yousefi

et al. 2024

Immunology Letters

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The immunomodulatory effect of intradermal allogeneic PBMC therapy in patients with recurrent spontaneous abortion

Sarkesh

Sorkhabi

Parhizkar

et al. 2023

Journal of Reproductive Immunology

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Cholesterol sulfate prevents maternal–fetal conflict by locally modulating immune reactivity

Hirotani,

Kunimura,

Maeda

et al. 2024

Preprint

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Although placental mammals are at high risk of maternal-fetal immune conflict, it is unclear how the semi-allogeneic fetus avoids rejection. Cholesterol sulfate (CS) is a bioactive metabolite that inhibits leukocyte migration and activation. This study investigated the roles and cells associated with CS in pregnant mice and humans. CS was sequentially produced by maternal-derived endometrial cells and fetal-derived placental trophoblasts before and after placentation. When mated with allogeneic males, CS-deficient mice showed increased fetal resorption rates under induced placental inflammation. This phenotype disappeared when the activity of the CS-producing enzyme was restored in the placenta. Placental CS levels were reduced in patients with "villitis of unknown etiology." Thus, we uncovered the spatiotemporal control of CS production and its relevance to local immunosuppression during pregnancy.

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Fetus, as an allograft, evades the maternal immunity

Cited by 3 publications

References 150 publications

The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss

The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss

The immunomodulatory effect of intradermal allogeneic PBMC therapy in patients with recurrent spontaneous abortion

Cholesterol sulfate prevents maternal–fetal conflict by locally modulating immune reactivity

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