Fibrin glue as cement for HA-granules

Wittkampf, Albert R.M.

doi:10.1016/s1010-5182(89)80019-8

Cited by 51 publications

(21 citation statements)

References 16 publications

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“…The 3D mesh of fibrin sealant interpenetrates the macro-and micro-porous structure of calcium orthophosphate ceramics [9]. The physical, chemical, and biological properties of calcium orthophosphate bioceramics and the fibrin glue might be cumulated in biocomposites, suitable for preparation of advanced bone grafts [707][708][709][710][711][712][713][714][715][716][717][718].…”

Section: Biocomposites With Collagenmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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Section: Biocomposites With Collagenmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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“…[29][30][31] α-TCP is predominant during bone resorption in the early stage of bone healing; [32][33][34][35] this may lead to technically difficulties in both the filling of particles to fit the bone defects and their delivery to form the desired shape. [36][37][38][39][40] However, cement type calcium phosphate material in paste form processes self-setting property in situ, thereby solving these technical problems. [41][42][43][44] The characteristic properties of the self setting materials work to prevent intervention for undesirable connective tissues or dispersion of the calcium phosphate particles in to the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

Okabe

Ueki

Marukawa

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery Abstract Purpose: The purpose of this study was to histologically and immuno-histochemically evaluate bone formation using both of self-setting α-tricalcium phosphate (α-TCP; BIOPEX ® ) and absorbable plate (Super FIXSORB ® -MX) in rabbit cranium bone.Study design: Adult male Japanese white rabbits (n=16, 12-16 weeks, 2.5-3.0 kg) were used. The surgical defects were made in the nasal bone of a rabbit and BIOPEX ® was implanted in the left side and no material in the right side. Two-hall-absorbable plate and two screws (Super FIXSORB ® -MX) were fixed across the defect in each side. The rabbits were sacrificed at1, 4, 12 and 24 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immune-histochemical analysis, the specimens were treated with bone morphogenetic protein-2 (BMP-2) antibodies. Finally, these were evaluated microscopically.Results: New bone formation was observed in the region of absorbable plate and nasal membrane after more than 4 weeks. The area of BIOPEX ® ＋new bone was significantly 3 larger than that of control side after 1, 4 and 12 weeks (P<0.05). The number of BMP-2 stained cell in experimental side was significantly larger than that in control side after 4 and 12 weeks (P<0.05). Conclusion

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“…To recover the native bone's height, a grafting material should prevent the invasion of the surrounding connective tissue into the defect. It is difficult to fill bone defects with calcium phosphate particles due to their dispersion and absence of adherent properties (Desjardins, 1985;Propper, 1985;Wittkampf, 1988Wittkampf, , 1989; moreover, such materials may permit the intrusion of connective tissue into the grafted area. Self-setting BIOPEX-R 1 , however, immediately hardens and tightly adheres to the bone matrix in vivo (Hao et al, 2004;Kurashina et al, 1997a,b) and, in our study, succeeded to recover favorable alveolar height.…”

Section: Discussionmentioning

confidence: 99%

“…However, technical difficulties when filling up the defects and/or shaping due to the fragility and dispersion may be a disadvantage (Desjardins, 1985;Propper, 1985;Wittkampf, 1988Wittkampf, , 1989. On the other hand, cement-type calcium phosphate materials are self-setting and able to adhere to the bone matrix in situ (Comuzzi et al, 2002;Koshino et al, 1995;Mirtchi et al, 1990Mirtchi et al, , 1999Miyamoto et al, 1995Miyamoto et al, , 1997.…”

Section: Introductionmentioning

confidence: 99%

Histological evaluation on bone regeneration of dental implant placement sites grafted with a self‐setting α‐tricalcium phosphate cement

Nakadate

Amizuka

et al. 2007

Microscopy Res & Technique

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This study aimed to evaluate the histological characteristics of the new bone formed at dental implant placement sites concomitantly grafted with a self-setting tricalcium phosphate cement (BIOPEX-R). Standardized defects were created adjacent to the implants in maxillae of 4-week-old male Wistar rats, and were concomitantly filled with BIOPEX-R. Osteogenesis was examined in two sites of extreme clinical relevance: (1) the BIOPEX-R-grafted surface corresponding to the previous alveolar ridge (alveolar ridge area), and (2) the interface between the grafting material and implants (interface area). At the alveolar ridge area, many tartrate-resistant acid phosphatase (TRAPase)-reactive osteoclasts had accumulated on the BIOPEX-R surface and were shown to migrate toward the implant. After that, alkaline phosphatase (ALPase)-positive osteoblasts deposited new bone matrix, demonstrating their coupling with osteoclasts. On the other hand, the interface area showed several osteoclasts initially invading the narrow gap between the implant and graft material. Again, ALPase-positive osteoblasts were shown to couple with osteoclasts, having deposited new bone matrix after bone resorption. Transmission electron microscopic observations revealed direct contact between the implant and the new bone at the interface area, although few thin cells could still be identified. At both the alveolar ridge and the interface areas, newly formed bone resembled compact bone histologically. Also, concentrations of Ca, P, and Mg were much alike with those of the preexistent cortical bone. In summary, when dental implant placement and grafting with BIOPEX-R are done concomitantly, the result is a new bone that resembles compact bone, an ideal achievement in reconstructive procedures for dental implantology.

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Fibrin glue as cement for HA-granules

Cited by 51 publications

References 16 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

Histological evaluation on bone regeneration of dental implant placement sites grafted with a self‐setting α‐tricalcium phosphate cement

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