Fibrinogen After Coronary Angioplasty as a Risk Factor for Restenosis

Montalescot, Gilles; Ankri, Annick; Vicaut, Éric; Drobinski, G; Grosgogeat, Y; Thomas, Daniel

doi:10.1161/01.cir.92.1.31

Cited by 110 publications

(48 citation statements)

References 38 publications

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“…1,4,5,13,16,17) The results of this study extend our previous observations, demonstrating the predictive value of measuring plasma levels of IL-8 for early complications after coronary interventions. Buffon, et al reported that the preprocedural CRP level is a powerful predictor of both early and late outcome in patients undergoing single vessel PTCA.…”

Section: Discussionsupporting

confidence: 86%

<b>Plasma Levels of IL-8 Predict Early Complications in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention</b>

Qi¹,

Li²,

Gu³

et al. 2003

Jpn Heart J

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SUMMARYThe aim of the present study was to investigate the prognostic value of plasma interleukin-8 (IL-8) for early complications after percutaneous coronary intervention (PCI).The pre-and postprocedural plasma levels of IL-8 and serum C-reactive protein (CRP) were examined by immunoassay, and the expression of CD11b/CD18 on neutrophils was assessed by flow cytometry. Early complications (abrupt occlusion, threatened abrupt occlusion, early recurrence of ischemia, myocardial infarction, cardiac sudden death, and target vessel revascularization) occurred intra-procedure and 30 days after PCI and were observed in 121 consecutive patients with coronary heart disease.Sixteen patients with early complications had high preprocedural levels and high postprocedural differentials of IL-8, CRP, and CD11b/CD18 compared to those without complications (all P < 0.05). The occurrence of complications showed a significant increase in the patients according to the tertiles of IL-8, CRP, and CD11b / CD18. Preprocedural levels of IL-8 (RR = 5.864, CI = 1.658 −20.734, P = 0.006) and diabetes (RR = 1.587, CI = 1.246 − 2.132, P = 0.038) were independent predictors of early complications. There were significant correlations in the postprocedural differential between IL-8 and CD11b/ CD18 (r = 0.776, P = 0.002) in patients with complications.The results reveal that the early complications after PCI contribute to preprocedural inflammatory responses. Normal levels of IL-8 may be powerful negative predictors of early complications in patients with CHD following PCI. (Jpn Heart J 2003; 44: 451-461) Key words: Percutaneous coronary intervention (PCI), IL-8, C-reactive protein (CRP), CD11b/CD18, Complications PERCUTANEOUS coronary intervention (PCI) is an established myocardial revascularization procedure. However, the high initial success rate is limited by the risk of acute complications, which range from 5% to 30% in unstable patients.1,2) It would be desirable to preprocedurally predict the risks of complications related to PCI in patients who might benefit from early prevention and addiFrom

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Section: Discussionsupporting

confidence: 86%

<b>Plasma Levels of IL-8 Predict Early Complications in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention</b>

Qi¹,

Li²,

Gu³

et al. 2003

Jpn Heart J

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“…High vWF levels have been associated with CAD (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In the present study patients showed higher plasma vWF levels than controls, but this difference was not significant.…”

Section: Discussioncontrasting

confidence: 65%

“…High levels of vWF have been associated with cardiovascular disorders such as ischemic heart disease, peripheral and pulmonary vascular disease, cerebrovascular disease, left ventricular aneurysm, atrial fibrillation, and deep venous thrombosis, as reviewed by Lip and Blann (1). Some studies have shown that high plasma vWF levels are a significant and independent predictor of cardiovascular risk in subjects with coronary artery disease (CAD) (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), but few studies have exam-D. Simon et al ined the relationships between vWF genotypes and coronary heart disease (12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

Simon

Paludo

Ghisleni

et al. 2003

Braz J Med Biol Res

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High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD.

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“…Other studies conducted by Montalescot et al (1995) demonstrated that patients with restenosis showed elevations in several procoagulant factors such as PAI-1, tissue plasminogen activator antigen, fibrinogen, and factors VII and VIII. In addition, Ishiwata et al (1997) identified depression of the fibrinolytic response in patients who developed restenosis post-PCI as compared to those patients who did not develop restenosis.…”

Section: Oxidative Stress and Restenosismentioning

confidence: 92%

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

et al. 2006

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Restenosis is one of the major adverse outcomes of Percutaneous CoronaryIntervention (PCI). Previous studies have shown conflicting reports for homocysteine as a predictor of restenosis following PCI. The conflicting reports may be due to oxidative factors (stimulation of polymorphonuclear leukocyte [PMNL]-induced reactive oxygen species generation, xanthine-xanthine oxidase, and arachidonic acid metabolism) other than homocysteine which could cause endothelial cell dysfunction leading to restenosis.Malondialdehyde (MDA), a lipid peroxidation product, is a marker for oxidative stress and is related to all oxidative factors. Therefore, it is possible that serum MDA may be a better predictor of restenosis than plasma homocysteine. The purpose of this study is to determine whether or not the pre-procedural serum MDA and plasma homocysteine levels are elevated in patients who develop restenosis post PCI.The study included fifty-one patients undergoing elective PCI who consented to participate in a protocol that was approved by the Ethics Committee of the University of Saskatchewan. Homocysteine and malondialdehyde were measured in the plasma and serum respectively. Blood samples were collected pre-procedural, 0 time, 8 hours, 24 hours, and 6 months post-procedure. Exercise tolerance tests were performed at two weeks, and six months post-procedure to determine if there was any evidence of restenosis.The results of the study showed that pre-procedural values of plasma homocysteine in the restenosis and non-restenosis groups were 10.37 ± 0.46 and 10.73 ± 0.49 respectively. These values were not significantly different (p=0.60) between the groups. The pre-procedural levels of plasma homocysteine were not significantly ii different (p=0.08) from the post-PCI values of those patients who did not develop restenosis at the 6-month time interval. However, the pre-procedural levels of plasma homocysteine were significantly different from the post-PCI values of those patients in the restenosis group at the 24hr (p=0.04) and 6-month (p=0.002) time intervals. In the restenosis group there was a significant increase (24%) after six months in the values of homocysteine from the pre-procedural levels. Thus, this indicates that restenosis is associated with higher post-PCI levels of homocysteine.The pre-procedural levels of serum MDA in the restenosis and non-restenosis groups were 0.124± 0.16 and 0.147± 0.02 respectively. There was no significant difference (p=0.60) between the two groups. There was also no significant difference The results suggest that pre-procedural levels of plasma homocysteine and serum MDA were not predictors of restenosis following PCI. However, the post-PCI sixmonth levels of both homocysteine and MDA are predictors of restenosis. Moreover, the post-PCI levels of MDA were better predictors of restenosis than the post-PCI levels of homocysteine because the increase in MDA levels were greater at six months than the rise in homocysteine levels at the same time interval.iii ACKNOWLEDGEMENTS

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Fibrinogen After Coronary Angioplasty as a Risk Factor for Restenosis

Cited by 110 publications

References 38 publications

<b>Plasma Levels of IL-8 Predict Early Complications in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention</b>

<b>Plasma Levels of IL-8 Predict Early Complications in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention</b>

Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

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