Fibrinogen and Its Relations to Subclinical Extracoronary and Coronary Atherosclerosis in Hypercholesterolemic Men

Levenson, Jaime; Giral, Philippe; Mégnien, Jean-Louis; Gariepy, Jérôme; Plainfossé, M. C.; Simon, Alain

doi:10.1161/01.atv.17.1.45

Cited by 37 publications

(30 citation statements)

References 47 publications

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“…In the large ECAT study (1993) no association between fibrinogen, PAI-1 activity, leukocyte count and extension of coronary heart disease was found. Levenson et al (1997) analyzed the prognostic value of fibrinogen in hypercholesterolemic patients. The value of fibrinogen increased according to the number of diseased sites and suggests that such an increase may be a marker of the extent of arterial disease.…”

Section: Discussionmentioning

confidence: 99%

Association of C-Reactive Protein with the Presence and Extent of Angiographically Verified Coronary Artery Disease

Memon

Spasojević‐Kalimanovska

Bogavac-Stanojević

et al. 2006

Tohoku J. Exp. Med.

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Prospective studies have demonstrated that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and fibrinogen, predict future cardiovascular disease risk. However, the association between the hsCRP and fibrinogen levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. The aim of our casecontrol study was to assess the association of inflammatory markers with the occurrence and extent of CAD. Serum hsCRP and plasma fibrinogen levels were measured in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed ( 50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease. The hsCRP and fibrinogen levels were significantly higher in patients than in controls ( p < 0.001). Although the hsCRP and fibrinogen levels tended to increase with the number of stenotic vessels, the differences were only significant for hsCRP ( p < 0.01). Regression analysis indicated hsCRP as an independent predictor for the presence (OR = 3.573, p < 0.05) and extent of CAD (β = 1.095, p < 0.05). In conclusion, the present study is the first report concerning the frequency distribution of hsCRP in Serbian healthy subjects and CAD patients. We have shown that elevated levels of hsCRP are associated with the presence and extent of CAD.atherosclerosis; inflammation; fibrinogen; hsCRP; coronary artery disease

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Section: Discussionmentioning

confidence: 99%

Association of C-Reactive Protein with the Presence and Extent of Angiographically Verified Coronary Artery Disease

Memon

Spasojević‐Kalimanovska

Bogavac-Stanojević

et al. 2006

Tohoku J. Exp. Med.

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“…The linkage between insignificant atherosclerosis and fibrinogen and creatinine level corresponded to previous findings. Levenson et al 20,21 demonstrated that prevalece of atherosclerotic plaques was significantly more pronounced with increasing tertile of fibrinogen levels. The authors also found the synergic effect between fibrinogen and total/HDL cholesterol ratio in formation of subclinical coronary and extracoronary atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Association Between Laboratory Markers and Presence of Coronary Artery Disease

Kincl¹,

Panovský²,

Meluzı́n³

et al. 2010

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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The aim of this paper is to elucidate the relation between laboratory markers and coronary artery disease (CAD). Methods. The study involved 1254 consecutive patients with suspected or known CAD referred for coronary angiography. The blood samples including blood cell count, C-reactive protein, fibrinogen, uric acid, creatinine, and lipid spectrum were obtained after overnight fasting. One hundred and thirty-three patients were excluded due to incomplete records or inacceptable laboratory values. Differences among groups were tested with one-way ANOVA and Bonferroni post-hoc test for continuous variables and with chi-square test for categorical variables. Univariate and multivariate logistic regression was adopted for the analysis of risk factors and development of models for classification of patients into clinical categories.Results. The linear logistic regression showed association of patient's biochemical markers with the presence of disease. Both acute and chronic CAD were associated with leukocyte count (Odds ratios 1.45 and 1

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“…Echogenic properties of carotid plaques have been associated with the risk of cardiovascular and cerebrovascular events in different patient populations [50][51][52][53]. Echolucent carotid plaques may help to identify patients at greater risk for future stroke [48,49] or to predict coronary events [54][55][56].…”

Section: Other Methods Of Plaque Measurement To Predict Cardiovasculamentioning

confidence: 99%

“…Among 693 asymptomatic patients with hypercholesterolaemia, Levenson [49] reported a prevalence of atherosclerotic lesions in 25% within carotid arteries, 34% within the aorta and in 51% within the femoral arteries. In the LiVicordia study, Kristenson [40] found a prevalence of femoral plaques in comparison to carotid arteries in 200 randomly sampled 50-year-old asymptomatic men.…”

Section: Correlation Between Plaques and Cardiovascular Riskmentioning

confidence: 99%

Cardiovascular risk prediction with ultrasound

2010

Cardiovasc Med

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SummaryThis paper addresses primary care physicians, cardiologists, internists, angiologists and doctors desirous of improving vascular risk prediction in primary care.Many cardiovascular risk factors act aggressively on the arterial wall and result in atherosclerosis and atherothrombosis. Cardiovascular prognosis derived from ultrasound imaging is, however, excellent in subjects without formation of intimal thickening or atheromas. Since ultrasound visualises the arterial wall directly, the information derived from the arterial wall may add independent incremental information to the knowledge of risk derived from global risk assessment. This paper provides an overview on plaque imaging for vascular risk prediction in two parts:Part 1: Carotid IMT is frequently used as a surrogate marker for outcome in intervention studies addressing rather large cohorts of subjects. Carotid IMT as a risk prediction tool for the prevention of acute myocardial infarction and stroke has been extensively studied in many patients since 1987, and has yielded incremental hazard ratios for these cardiovascular events independently of established cardiovascular risk factors. However, carotid IMT measurements are not used uniformly and therefore still lack widely accepted standardisation. Hence, at an individual, practicebased level, carotid IMT is not recommended as a risk assessment tool.The total plaque area of the carotid arteries (TPA) is a measure of the global plaque burden within both carotid arteries. It was recently shown in a large Norwegian cohort involving over 6000 subjects that TPA is a very good predictor for future myocardial infarction in women with an area under the curve (AUC) using a receiver operating curves (ROC) value of 0.73 (in men: 0.63). Further, the AUC for risk prediction is high both for vascular death in a vascular prevention clinic group (AUC 0.77) and fatal or nonfatal myocardial infarction in a true primary care group (AUC 0.79). Since TPA has acceptable reproducibility, allows calculation of posttest risk and is easily obtained at low cost, this risk assessment tool may come in for more widespread use in the future and also serve as a tool for atherosclerosis tracking and guidance for intensity of preventive therapy. However, more studies with TPA are needed.Part 2: Carotid and femoral plaque formation as detected by ultrasound offers a global view of the extent of atherosclerosis. Several prospective cohort studies have shown that cardiovascular risk prediction is greater for plaques than for carotid IMT. The number of arterial beds affected by significant atheromas may simply be added numerically to derive additional information on the risk of vascular events.A new atherosclerosis burden score (ABS) simply calculates the sum of carotid and femoral plaques encountered during ultrasound scanning. ABS correlates well and independently with the presence of coronary atherosclerosis and stenosis as measured by invasive coronary angiogram. However, the prognostic power of ABS as an independent marker of ris...

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Fibrinogen and Its Relations to Subclinical Extracoronary and Coronary Atherosclerosis in Hypercholesterolemic Men

Cited by 37 publications

References 47 publications

Association of C-Reactive Protein with the Presence and Extent of Angiographically Verified Coronary Artery Disease

Association of C-Reactive Protein with the Presence and Extent of Angiographically Verified Coronary Artery Disease

Association Between Laboratory Markers and Presence of Coronary Artery Disease

Cardiovascular risk prediction with ultrasound

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