Fibroblast growth factor modulates mast cell recruitment in a murine model of prostate cancer

Ronca, Roberto; Tamma, Roberto; Coltrini, Daniela; Ruggieri, Simona; Presta, Marco; Ribatti, Doménico

doi:10.18632/oncotarget.19773

Cited by 31 publications

(23 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Shao et al reported that FGF-FGFR signaling plays an important role in transformation induced by the loss of a PTEN tumor suppressor when combined with the expression of the TMPRSS2/ERG fusion gene [26], and activation of FGF-FGFR signaling by FGF8b overexpression in PTEN deficiency is reported to be associated with prostate tumorigenesis [27]. FGF-FGFR signaling is also related to the induction of an inflammatory response in PCa tissues [28]. The involvement of aberrant FGFR1 signaling in the progression of PCa in particular was demonstrated in several studies.…”

Section: Effects Of the Restoration Of Fgfr2iiib In Prostate Cancementioning

confidence: 99%

Fibroblast Growth Factor Family in the Progression of Prostate Cancer

Teishima

Hayashi

Nagamatsu

et al. 2019

JCM

View full text Add to dashboard Cite

Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) play an important role in the maintenance of tissue homeostasis and the development and differentiation of prostate tissue through epithelial-stromal interactions. Aberrations of this signaling are linked to the development and progression of prostate cancer (PCa). The FGF family includes two subfamilies, paracrine FGFs and endocrine FGFs. Paracrine FGFs directly bind the extracellular domain of FGFRs and act as a growth factor through the activation of tyrosine kinase signaling. Endocrine FGFs have a low affinity of heparin/heparan sulfate and are easy to circulate in serum. Their biological function is exerted as both a growth factor binding FGFRs with co-receptors and as an endocrine molecule. Many studies have demonstrated the significance of these FGFs and FGFRs in the development and progression of PCa. Herein, we discuss the current knowledge regarding the role of FGFs and FGFRs—including paracrine FGFs, endocrine FGFs, and FGFRs—in the development and progression of PCa, focusing on the representative molecules in each subfamily.

show abstract

Section: Effects Of the Restoration Of Fgfr2iiib In Prostate Cancementioning

confidence: 99%

Fibroblast Growth Factor Family in the Progression of Prostate Cancer

Teishima

Hayashi

Nagamatsu

et al. 2019

JCM

View full text Add to dashboard Cite

show abstract

“…The tissue density of mast cells is highly correlated with the extent of normal and pathologic angiogenesis ( 57 ). Mast cells are recruited by FGF2 ( 58 ) and, in turn, may release FGF2, as well as other pro-angiogenic factors, leading to EC activation ( 59 , 60 ). Accordingly, mast cells and their isolated secretory granules induce an angiogenic response in the chick embryo CAM assay ( 61 ) that is inhibited by neutralizing anti-FGF2 antibodies ( 40 ).…”

Section: Fgf2-dependent Angiogenesis and Inflammationmentioning

confidence: 99%

“…As a consequence of the anti-FGF2/anti-angiogenic activity of PTX3, FGF2-dependent syngeneic tumor grafts of different origin were characterized by impaired FGFR1 activation and reduced CD31 + vascularization and tumor growth when injected in TgN(Tie2-hPTX3) mice ( 106 ). Notably, the TRAMP-C2 prostate adenocarcinoma cell grafts generated in TgN(Tie2-hPTX3) mice were characterized also by a significant decrease of the mast cell infiltrate into the lesion ( 58 ). These data, in keeping with previous observations about the capacity of mast cells to respond chemotactically to FGF2, provide evidence about a relationship among FGF2-dependent mast cell recruitment, angiogenesis, and tumor growth in prostate adenocarcinoma, all hampered by PTX3.…”

Section: Ptx3/fgf Interactionmentioning

confidence: 99%

Long Pentraxin-3 Modulates the Angiogenic Activity of Fibroblast Growth Factor-2

et al. 2018

Self Cite

View full text Add to dashboard Cite

Angiogenesis, the process of new blood vessel formation from pre-existing ones, plays a key role in various physiological and pathological conditions. Alteration of the angiogenic balance, consequent to the deranged production of angiogenic growth factors and/or natural angiogenic inhibitors, is responsible for angiogenesis-dependent diseases, including cancer. Fibroblast growth factor-2 (FGF2) represents the prototypic member of the FGF family, able to induce a complex “angiogenic phenotype” in endothelial cells in vitro and a potent neovascular response in vivo as the consequence of a tight cross talk between pro-inflammatory and angiogenic signals. The soluble pattern recognition receptor long pentraxin-3 (PTX3) is a member of the pentraxin family produced locally in response to inflammatory stimuli. Besides binding features related to its role in innate immunity, PTX3 interacts with FGF2 and other members of the FGF family via its N-terminal extension, thus inhibiting FGF-mediated angiogenic responses in vitro and in vivo. Accordingly, PTX3 inhibits the growth and vascularization of FGF-dependent tumors and FGF2-mediated smooth muscle cell proliferation and artery restenosis. Recently, the characterization of the molecular bases of FGF2/PTX3 interaction has allowed the identification of NSC12, the first low molecular weight pan-FGF trap able to inhibit FGF-dependent tumor growth and neovascularization. The aim of this review is to provide an overview of the impact of PTX3 and PTX3-derived molecules on the angiogenic, inflammatory, and tumorigenic activity of FGF2 and their potential implications for the development of more efficacious anti-FGF therapeutic agents to be used in those clinical settings in which FGFs play a pathogenic role.

show abstract

“…Most members of the pentraxin family can activate the PI3K/AKT/mTOR pathways, thereby interfering with the normal cell- cycle. The neuronal pentraxins and PTX3 possess specific unique receptors that mediates tumor progression ( 15 ). In this review, we have summarized the basic characteristics and functions of each pentraxin family member and highlighted the existing connection between their structures and specific roles in tumor progression.…”

Section: Introductionmentioning

confidence: 99%

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Wang

Zou

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4). Each group shares a similar structure with the pentameric complexes arranged in a discoid shape. Previous studies revealed the functions of different pentraxin family members. Most of them are associated with human innate immunity. Inflammation has commonly been associated with tumor progression, implying that the pentraxin family might also participate in tumor progression. Therefore, we reviewed the basic characteristics and functions of the pentraxin family and their role in tumor progression.

show abstract

Fibroblast growth factor modulates mast cell recruitment in a murine model of prostate cancer

Cited by 31 publications

References 45 publications

Fibroblast Growth Factor Family in the Progression of Prostate Cancer

Fibroblast Growth Factor Family in the Progression of Prostate Cancer

Long Pentraxin-3 Modulates the Angiogenic Activity of Fibroblast Growth Factor-2

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Contact Info

Product

Resources

About