Fighting against Skin Aging

Zhang, Shoubing; Duan, Enkui

doi:10.1177/0963689717725755

Cited by 519 publications

(297 citation statements)

References 103 publications

(121 reference statements)

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“…Furthermore, many studies showed that skin aging and skin wrinkling may be reduced by the action of the antioxidant activity of various botanical extracts [58,59]. Aumeeruddy-Elalfi et al [22] showed that the inhibitory potential of essential oils extracted from some medicinal plants make them potential candidates for the cosmetic (skin aging) and pharmaceutical industries.…”

Section: Discussionmentioning

confidence: 99%

Phenol Content and Antioxidant and Antiaging Activity of Safflower Seed Oil (Carthamus Tinctorius L.)

et al. 2019

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The phenol content of vegetable oil and its antioxidant activity are of primary interest for human health. Oilseed species are considered important sources of these compounds with medicinal effects on a large scale. Total phenol content (TPC) and antioxidant activity (AA) of safflower oil were previously studied. Nevertheless, there is no report on genotypic differences and antiaging activity of safflower oil. The aim of this study was to determine the TPC, diphenyl-picrylhydrazyl (DPPH), and antiaging activity on three respective accessions from Syria, France, and Algeria of seed oil of safflower grown under semi-arid conditions during 3 consecutive years (2015, 2016, and 2017). The results showed that phenol content as well as antioxidant and antiaging activity varied according to both genotype and years. In 2017, the mean value of TPC in oil seed was two times higher than in 2015 and 2016. Moreover, accessions presented different TPC values depending on the year. The highest antioxidant activity was observed among accessions in 2017 compared to 2015 and 2016. As expected, a positive correlation was found between TPC and antioxidant activity. The inhibition in the collagenase assay was between 47% and 72.1% compared to the positive control (83.1%), while inhibition in the elastase assay of TPC ranged from 32.2% to 70.3%, with the positive control being 75.8%. These results highlight the interest of safflower oil as a source of phenols with valuable antioxidant and antiaging activity, and uses for cosmetics.

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Section: Discussionmentioning

confidence: 99%

Phenol Content and Antioxidant and Antiaging Activity of Safflower Seed Oil (Carthamus Tinctorius L.)

et al. 2019

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“…Skin aging, a complex biological process that can be modulated by several intrinsic (chronological or intrinsic skin aging) and environmental factors (e.g., UV radiation, extrinsic skin aging), is accompanied by both phenotypic changes in cutaneous cells and structural and functional changes of extracellular matrix (ECM) components, namely collagens, elastin and proteoglycans that are needed to maintain the tensile strength, elasticity and hydration of the skin [4,5]. Mitochondrial DNA damage, increased reactive oxygen species (ROS) production, and telomere shortening are considered to be major players during intrinsic skin aging [4,5]. Moreover, the accumulation of replicative old senescent skin cells may also promote the pathological remodeling of ECM [4].…”

Section: Introductionmentioning

confidence: 99%

Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells

Adamczyk‐Grochala

Wnuk

Duda³

et al. 2020

Nutrients

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More recently, we have proposed a safe non-vector approach to modifying the biochemical profiles of the microalga Planktochlorella nurekis and obtained twelve clones with improved content of lipids and selected pigments and B vitamins and antioxidant activity compared to unaffected cells. In the present study, the biological activity of water and ethanolic extracts of modified clones is investigated in the context of their applications in the cosmetic industry and regenerative medicine. Extract-mediated effects on cell cycle progression, proliferation, migration, mitogenic response, apoptosis induction, and oxidative and nitrosative stress promotion were analyzed in normal human fibroblasts and keratinocytes in vitro. Microalgal extracts did not promote cell proliferation and were relatively non-cytotoxic when short-term treatment was considered. Long-term stimulation with selected microalgal extracts attenuated the development of oxidative stress-induced senescence in skin cells that, at least in part, was correlated with nitric oxide signaling and increased niacin and biotin levels compared to an unmodified microalgal clone. We postulate that selected microalgal extracts of Planktochlorella nurekis can be considered to be used in skin anti-aging therapy.

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“…31 Aging, due to both intrinsic and extrinsic factors, affects the overall ability of the skin to retain moisture and produce its own hyaluronic acid. 32 Evidence suggests that hyaluronic acid delivery through injections and formulations is a valuable solution for retaining moisture within the skin. 33 Several analyses were performed on the formulated emulsion to demonstrate applicability.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide-releasing emulsion with hyaluronic acid and vitamin E

et al. 2019

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S-Nitrosoglutathione (GSNO) is a naturally available S-nitrosothiol that can be incorporated into non-toxic formulations intended for topical use. The value of nitric oxide (NO) delivered topically relates to its wellstudied physiological functions such as vasodilation, angiogenesis, cell proliferation and broad-spectrum antibacterial activity. Previously reported topical NO-releasing substrates include polymeric materials that exhibit non-toxic behaviors on dermal tissue such as polyethylene glycol. However, they do not serve as humectants nor provide vitamins to the skin. In this study, GSNO was added to an emulsion that was fortified with a-tocopheryl acetate (vitamin E) and hyaluronic acid. The average total NO content for the NO-releasing emulsion was 58 AE 8 mmol g À1 at 150 C and the cumulative NO release over 53 h at physiological temperature (37.4 C) was 46 AE 4 mmol g À1 . The GSNO concentration in the lotion was optimized in order to reach a pH value similar to that of human skin (pH 5.5). The viscosity was analyzed using a rotational viscometer for the S-nitrosated and the non-nitrosated emulsions to obtain a material that can be readily spread on dermal tissue. The viscosity values obtained ranged from 7.88 AE 0.99 to 8.50 AE 0.36 Pa s. Previous studies have determined that the viscosity maximum for lotions is 100 Pa s. A low viscosity increases the diffusion coefficient of active ingredients to the skin given that they are inversely proportional as described by the Einstein-Smoluchowski equation. The effect of the Snitrosated and non-nitrosated emulsions on adult human dermal fibroblasts (HDFs) was assessed in comparison to untreated HDFs using Colorimetric Cell Viability Kit I-WST-8. The findings indicate that neither the S-nitrosated nor non-nitrosated emulsions induced cytotoxicity in HDFs. † Electronic supplementary information (ESI) available: Nitric oxide release proles using a chemiluminescence-based detection method are shown (n ¼ 3). See

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Fighting against Skin Aging

Cited by 519 publications

References 103 publications

Phenol Content and Antioxidant and Antiaging Activity of Safflower Seed Oil (Carthamus Tinctorius L.)

Phenol Content and Antioxidant and Antiaging Activity of Safflower Seed Oil (Carthamus Tinctorius L.)

Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells

Nitric oxide-releasing emulsion with hyaluronic acid and vitamin E

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