Final results of a phase I–II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration

Soler, Robert; Orozco, Lluís; Munar, Ana; Huguet, Marina; López, Ramon; Vives, Joaquim; Coll, Ruth; Codinach, Margarita; García‐López, Joan

doi:10.1016/j.knee.2015.08.013

Cited by 152 publications

(121 citation statements)

References 30 publications

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“…The ARomDe score monitors the quality of life via the measurement of three dimensions, including pain and function recovery and behavior. It is consistent with many previous studies, which generally evaluate the improvement of models and human with knee osteoarthritis via the achievement of pain relief [2,7,14,19,20,26,28,29] and function recovery [1,2,26,27] and emotional behavior [1,19,20,27].…”

Section: Special Issue On "Human Stem Cells and Transplantation": Open supporting

confidence: 90%

“…In this decade, an alternative medicine for knee OA was highlighted as mesenchymal stem cell (MSC) therapy [12][13][14]. The advantage of stem cell therapy over traditional approaches is the restoration of cartilage function in the knee.…”

Section: Special Issue On "Human Stem Cells and Transplantation": Open mentioning

confidence: 99%

“…The advantage of stem cell therapy over traditional approaches is the restoration of cartilage function in the knee. MSC promotes the migration of endogenous repairing cells to injury sites and the self-healing process of the knee joint cartilage, resulting in relief of OA symptoms and an improved patient functional status [14][15][16][17][18]. Whether or not regeneration of knee cartilage has been achieve by stem cell therapy in elderly people, a better quality of life; reduction of pain, a disability of daily living activities and mental suffering, is worth the effort to try.…”

Section: Special Issue On "Human Stem Cells and Transplantation": Open mentioning

confidence: 99%

“…Attempting to provide a new simple treatment of MSC therapy is needed. Although, stem cell therapy in OA knee has been studied in many previous works, most of them focus their attention on the neo-cartilage tissue regeneration [12,14,22,37,38], which may not be a main interest in older patients. In contrast, stem cell therapy based on quality of life instead of tissue regeneration would become advantageous and a major interest of OA treatment in older patients.…”

Section: Special Issue On "Human Stem Cells and Transplantation": Open mentioning

confidence: 99%

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Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Phermthai¹,

Chareancholvanich²

2017

IJST

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Section: Special Issue On "Human Stem Cells and Transplantation": Open supporting

confidence: 90%

Section: Special Issue On "Human Stem Cells and Transplantation": Open mentioning

confidence: 99%

Section: Special Issue On "Human Stem Cells and Transplantation": Open mentioning

confidence: 99%

Section: Special Issue On "Human Stem Cells and Transplantation": Open mentioning

confidence: 99%

See 2 more Smart Citations

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Phermthai¹,

Chareancholvanich²

2017

IJST

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“…Currently, there are 38 clinical trials registered, with 9 in Phase 1, 16 in joint-Phase 1/2, and 8 in Phase 2. Not surprisingly, more than 18 % of studies have published results on the safety and efficacy of MSCs for OA treatment [42–46, 94]. Overall, these studies demonstrate quite positive results regarding improvement in symptomatology—including pain—and joint repair as seen by cartilage regeneration.…”

Section: State Of Msc Clinical Research In Specific Immune-/inflammatmentioning

confidence: 99%

Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

et al. 2016

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Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune- and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.

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Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering

Fahy

Alini

Stoddart

2017

Journal Orthopaedic Research

185

138

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Articular cartilage is a load-bearing tissue playing a crucial mechanical role in diarthrodial joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical stimuli in the development of cartilage and maintenance of chondrocyte phenotype in adult tissues has been well documented. Furthermore, dysregulated loading is associated with cartilage pathology highlighting the importance of mechanical cues in cartilage homeostasis. The repair of damaged articular cartilage resulting from trauma or degenerative joint disease poses a major challenge due to a low intrinsic capacity of cartilage for self-renewal, attributable to its avascular nature. Bone marrow-derived mesenchymal stem cells (MSCs) are considered a promising cell type for cartilage replacement strategies due to their chondrogenic differentiation potential. Chondrogenesis of MSCs is influenced not only by biological factors but also by the environment itself, and various efforts to date have focused on harnessing biomechanics to enhance chondrogenic differentiation of MSCs. Furthermore, recapitulating mechanical cues associated with cartilage development and homeostasis in vivo, may facilitate the development of a cellular phenotype resembling native articular cartilage. The goal of this review is to summarize current literature examining the effect of mechanical cues on cartilage homeostasis, disease, and MSC chondrogenesis. The role of biological factors produced by MSCs in response to mechanical loading will also be examined. An in-depth understanding of the impact of mechanical stimulation on the chondrogenic differentiation of MSCs in terms of endogenous bioactive factor production and signaling pathways involved, may identify therapeutic targets and facilitate the development of more robust strategies for cartilage replacement using MSCs. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:52-63, 2018.

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Final results of a phase I–II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration

Cited by 152 publications

References 30 publications

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering

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