Fingerprint analysis and multi-component determination of Zibu Piyin recipe by HPLC with DAD and Q-TOF/MS method

Hong, Xuemin; Xu, Hui; Zhan, Lijun; Zhang, Lin

doi:10.1080/14786419.2015.1092147

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…Among them, the TOF mass analyzer, with high sensitivity and mass accuracy of the analysis, is suitable for structural analysis of unknown compounds. 40,41 Analysis and identication of herbal medicines by spectrum has been accepted as an effective identication method by most countries, which identies herbs by different wavelengths and penetrability of ultraviolet, uorescence, and infrared radiation. Aer the discovery of the near-infrared (NIR) region in 1800, NIR spectroscopy sprung up, reformed in the early 1950s, and was used in the 1970s.…”

Section: Modern Technology For Identifying Chemical Componentsmentioning

confidence: 99%

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Recent advances and effective strategies in the discovery and applications of natural products

et al. 2018

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Natural products are the most representative form of conventional therapy as compared to any other traditional or alternative medicine systems. They have numerous active components, either primary or secondary metabolites, which are associated with the diverse, intricate, and distinct characteristics of natural products and result in various pharmacological effects in clinic. However, some problems are associated with research on herb quality, which is the core of the drug industry, and restrict the development of this field to a certain extent. Quality-markers (Q-markers), a novel concept for quality assessment, open up a new avenue for promotion of healthy development of traditional medicine industry and improvement of the quality standard system to enhance traditional medicine or product quality standards. In this study, we first summarized the main factors affecting the quality of traditional medicines and natural products and importance for safety and then presented the concept of background and relevant factors of Q-markers. Moreover, the modern science technology and related methods used to identify the chemical composition have been discussed. Especially, based on the systematic analysis and discussion of the basic properties and clinical features of natural products, we have discussed new trends and effective strategies for identifying relevant Q-markers from herbs and probed the future research directions and challenges.

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Section: Modern Technology For Identifying Chemical Componentsmentioning

confidence: 99%

“…Among them, the TOF mass analyzer, with high sensitivity and mass accuracy of the analysis, is suitable for structural analysis of unknown compounds. 40,41 …”

Section: Modern Technology For Identifying Chemical Componentsmentioning

confidence: 99%

Recent advances and effective strategies in the discovery and applications of natural products

et al. 2018

View full text Add to dashboard Cite

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“…The MS/MS device is well suited for quantitative determination of known compounds in the selected reaction monitoring mode . In addition, TOF mass analyzers (eg, QTOF/MS) providing high sensitivity and mass accuracy are suitable for the structural elucidation of unknown compounds, and are particularly useful for the analysis of HM …”

Section: Mass Spectrometry: the “Microscope” For Chemical Structuresmentioning

confidence: 99%

Mass spectrometry‐driven drug discovery for development of herbal medicine

Zhang

Sun

Wang

2016

Mass Spectrometry Reviews

141

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Herbal medicine (HM) has made a major contribution to the drug discovery process with regard to identifying products compounds. Currently, more attention has been focused on drug discovery from natural compounds of HM. Despite the rapid advancement of modern analytical techniques, drug discovery is still a difficult and lengthy process. Fortunately, mass spectrometry (MS) can provide us with useful structural information for drug discovery, has been recognized as a sensitive, rapid, and high-throughput technology for advancing drug discovery from HM in the post-genomic era. It is essential to develop an efficient, high-quality, high-throughput screening method integrated with an MS platform for early screening of candidate drug molecules from natural products. We have developed a new chinmedomics strategy reliant on MS that is capable of capturing the candidate molecules, facilitating their identification of novel chemical structures in the early phase; chinmedomics-guided natural product discovery based on MS may provide an effective tool that addresses challenges in early screening of effective constituents of herbs against disease. This critical review covers the use of MS with related techniques and methodologies for natural product discovery, biomarker identification, and determination of mechanisms of action. It also highlights high-throughput chinmedomics screening methods suitable for lead compound discovery illustrated by recent successes.

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“…HPLC fingerprint analysis usually utilizes chromatogram technology to acquire specific and selective chemical compositions of TCM and the distribution of various chemical components can be determined based on fingerprint analysis. Due to its advantages, fingerprint analysis has been used in the QC process of TCM production, detection of raw medicinal materials, and evaluation of different TCM batches . Additionally, fingerprint analysis has been recommended by many QC agencies worldwide, such as the FDA, WHO, and EAEM .…”

Section: Introductionmentioning

confidence: 99%

Quality evaluation of moluodan concentrated pill using high‐performance liquid chromatography fingerprinting coupled with chemometrics

Tao

Zhang

et al. 2016

J of Separation Science

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In this study, a fast and effective high-performance liquid chromatography method was developed to obtain a fingerprint chromatogram and quantitative analysis simultaneously of four indexes including gallic acid, chlorogenic acid, albiflorin and paeoniflorin of the traditional Chinese medicine Moluodan Concentrated Pill. The method was performed by using a Waters X-bridge C reversed phase column on an Agilent 1200S high-performance liquid chromatography system coupled with diode array detection. The mobile phase of the high-performance liquid chromatography method was composed of 20 mmol/L phosphate solution and acetonitrile with a 1 mL/min eluent velocity, under a detection temperature of 30°C and a UV detection wavelength of 254 nm. After the methodology validation, 16 batches of Moluodan Concentrated Pill were analyzed by this high-performance liquid chromatography method and both qualitative and quantitative evaluation results were achieved by similarity analysis, principal component analysis and hierarchical cluster analysis. The results of these three chemometrics were in good agreement and all indicated that batch 10 and batch 16 showed significant differences with the other 14 batches. This suggested that the developed high-performance liquid chromatography method could be applied in the quality evaluation of Moluodan Concentrated Pill.

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Fingerprint analysis and multi-component determination of Zibu Piyin recipe by HPLC with DAD and Q-TOF/MS method

Cited by 11 publications

References 7 publications

Recent advances and effective strategies in the discovery and applications of natural products

Recent advances and effective strategies in the discovery and applications of natural products

Mass spectrometry‐driven drug discovery for development of herbal medicine

Quality evaluation of moluodan concentrated pill using high‐performance liquid chromatography fingerprinting coupled with chemometrics

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