First case of bilateral coronoid hyperplasia in monozygotic twin sisters—a new aetiological perspective?

Abstract

This report gives a new perspective to the aetiology of coronoid hyperplasia since it describes its occurrence in monozygotic twins and hence provides a strong argument in support of a genetic aetiology.

Bilateral coronoid hyperplasia causing painless limitation of mandibular movement

“…In addition, deficits in myogenic factors (MYF5/MYOD) cause coronoid and angular processes to be small or maintain complete defects [7] . Genetics and hormonal factors can also affect craniofacial size and morphologic characteristics [13] , [14] . Makek and Obwegeser indicated that different individual factors related to growth, which control generalized hypertrophy and longitudinal growth, may cause deformities [15] .…”

Situs Inversus Totalis in Twins: A Brief Review and a Life History / Twin Research: Twin Studies of Trisomy 21; Monozygotic Twin Concordance for Bilateral Coronoid Hyperplasia; Prenatal Hormonal Effects in Mixed-Sex Non-Human Primate Litters; Insurance Mandates and Twinning After In Vitro Fertilization / News Reports: First Report of Identical Twin Puppies; Twins Sisters Turn 100; Remembering an Identical Twin Production Designer; New York City Marathon Quadruplets

“…Researchers in the United Kingdom have reported the first case of mandibular coronoid hyperplasia (MCH) in a pair of 16-year-old MZ female twins of Afro-Caribbean origin (Khandavilli et al, 2016). MCH is a rare condition that involves a gradual reduction in the opening of the mouth.…”