First case of pneumonia-parapneumonic effusion due to Trichoderma longibrachiatum

Georgakopoulou, Vasiliki; Melemeni, Despoina; Mantzouranis, Konstantinos; Damaskos, Christos; Gkoufa, Aikaterini; Chlapoutakis, Serafeim; Garmpis, Nikolaos; Garmpi, Anna; Sklapani, Pagona; Τράκας, Νικόλαος; Tsiafaki, Xanthi

doi:10.1016/j.idcr.2021.e01239

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…In the absence of a clinical breakpoint, AST-adjusted antifungal therapy is recommended with low-quality evidence [ 66 ]. Although in some cases AST has been obtained and used to guide antifungal therapy [ 36 , 39 , 40 , 56 ], no recommendation regarding AST in Trichoderma spp. can be found in the literature.…”

Section: Discussionmentioning

confidence: 99%

Trichoderma spp.-Related Pneumonia: A Case Report in Heart–Lung Transplantation Recipient and a Systematic Literature Review

Burzio

Balzani

Montrucchio

et al. 2023

JoF

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Opportunistic and hospital-acquired infections are common among recipients of solid organ transplantation. New pathogens are increasingly reported in the intensive care unit (ICU) population. We report a case of a patient who developed Trichoderma spp.-related pneumonia (TRP) after heart–lung transplantation. In the absence of antifungal susceptibility testing, TRP was confirmed by histological examination, and empirical therapy with voriconazole and caspofungin was swiftly initiated. Complete resolution of pneumonia was obtained after prolonged combination therapy. Given the lack of guidelines, we conducted a systematic review to elucidate the diagnostic and therapeutic strategies to apply during Trichoderma infection. After deduplication and selection of full texts, we found 42 articles eligible for the systematic review. Pneumonia seems to be the most common clinical manifestation (31.8%). The most used antifungal therapy was amphotericin B, while combination therapy was also reported (27.3%). All the patients were immunocompromised except for one case. Despite the rarity of Trichoderma spp. infection, the increase in invasive fungal infections is of growing importance in ICU, considering their impact on mortality and the emergence of antifungal resistance. In the absence of prospective and multicenter studies, a review can provide useful insight regarding the epidemiology, clinical manifestations, and management of these unexpected challenges.

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Section: Discussionmentioning

confidence: 99%

Trichoderma spp.-Related Pneumonia: A Case Report in Heart–Lung Transplantation Recipient and a Systematic Literature Review

Burzio

Balzani

Montrucchio

et al. 2023

JoF

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“…In this research, a strain of T. longibrachiatum was shown to be a good candidate as a biological control agent. However, this species has been reported as an opportunistic human pathogen of immunosuppressed patients (Myoken et al, 2002;Lipový et al, 2021;Vasiliki et al, 2021). Therefore, the use of T. longibrachiatum T17BCMX as biological control agent should be restricted, though it showed excellent antagonistic activity in assays carried out under in vitro and in planta conditions.…”

Section: Discussionmentioning

confidence: 99%

Heritage grapevines as sources of biological control agents for Botryosphaeria dieback pathogens

DELGADO-RAMÍREZ,

SEPÚLVEDA,

RANGEL-MONTOYA

et al. 2023

Phytopathol. Mediterr.

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Grapevine trunk diseases cause severe damage in grapevines. Management strategies focus on protection of grapevine pruning wounds using chemical fungicides or biological control agents. Botryosphaeria dieback, caused mainly by Lasiodiplodia spp., is one of the main trunk diseases in northwest Mexico. This study obtained endophytic bacteria and fungi from the heritage grapevine Vitis vinifera cv. ‘Mission’ for potential biological control of Botryosphaeria dieback. A collection of 135 bacterial and 37 fungal isolates were obtained and initially tested for antagonistic activity against Lasiodiplodia brasiliensis. The most promising isolates belonging to Trichoderma and Bacillus spp. were selected and characterized to determine their modes of action. Bacillus isolates produced volatile organic compounds that inhibited growth of Neofusicoccum parvum, and diffusible organic compounds with antifungal effects against L. brasiliensis and N. parvum. Trichoderma isolates produced diffusible organic compounds and were mycoparasites. In greenhouse assays, plants inoculated with three Trichoderma asperellum isolates (T20BCMX, EF09BCMX, and EF11BCMX), B. amyloliquefaciens (BEVP26BCMX) or Bacillus sp. (rbES015), applied preventively in soil, gave up to 50% smaller necrotic lesions when compared with the plants inoculated only with L. brasiliensis. In the field, plants inoculated with three Bacillus isolates (BEVP02BCMX, BEVP26BCMX, BEVP31BCMX) or five Trichoderma (T11BCMX, T15BCMX, T17BCMX, T20BCMX, and EF11BCMX) had lesions up to four times smaller than control plants inoculated only with L. brasiliensis. This study has demonstrated the potential of heritage grapevines to provide biological control agents for Botryosphaeria dieback.

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“…T. longibrachiatum is frequently isolated from agricultural soils, mushrooms, and marine environments, and it grows better at tropical temperatures rather than in temperate climates [ 193 ]. This fungus has been reported to cause cardiac and pulmonary mycoses in immunocompromised humans [ 194 , 195 , 196 ]. Nonetheless, it has also been reported to be used as an important biocontrol agent [ 159 , 169 ], exerting parasitism and inducing plant defense systems, along with the production of several important secondary metabolites, as shown by the examples described below.…”

Section: Biocontrol Potential Of Registered Trichoderma ...mentioning

confidence: 99%

Trichoderma Species: Our Best Fungal Allies in the Biocontrol of Plant Diseases—A Review

Guzmán-Guzmán

Kumar

Santos-Villalobos

et al. 2023

Plants

120

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Biocontrol agents (BCA) have been an important tool in agriculture to prevent crop losses due to plant pathogens infections and to increase plant food production globally, diminishing the necessity for chemical pesticides and fertilizers and offering a more sustainable and environmentally friendly option. Fungi from the genus Trichoderma are among the most used and studied microorganisms as BCA due to the variety of biocontrol traits, such as parasitism, antibiosis, secondary metabolites (SM) production, and plant defense system induction. Several Trichoderma species are well-known mycoparasites. However, some of those species can antagonize other organisms such as nematodes and plant pests, making this fungus a very versatile BCA. Trichoderma has been used in agriculture as part of innovative bioformulations, either just Trichoderma species or in combination with other plant-beneficial microbes, such as plant growth-promoting bacteria (PGPB). Here, we review the most recent literature regarding the biocontrol studies about six of the most used Trichoderma species, T. atroviride, T. harzianum, T. asperellum, T. virens, T. longibrachiatum, and T. viride, highlighting their biocontrol traits and the use of these fungal genera in Trichoderma-based formulations to control or prevent plant diseases, and their importance as a substitute for chemical pesticides and fertilizers.

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First case of pneumonia-parapneumonic effusion due to Trichoderma longibrachiatum

Cited by 5 publications

References 27 publications

Trichoderma spp.-Related Pneumonia: A Case Report in Heart–Lung Transplantation Recipient and a Systematic Literature Review

Trichoderma spp.-Related Pneumonia: A Case Report in Heart–Lung Transplantation Recipient and a Systematic Literature Review

Heritage grapevines as sources of biological control agents for Botryosphaeria dieback pathogens

Trichoderma Species: Our Best Fungal Allies in the Biocontrol of Plant Diseases—A Review

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