The coupling of equatorial and low-latitude ionosphere has been an active area of research for many years. At low latitude, the occurrences of E and valley region irregularities during postsunset hours are obviously different from those around the magnetic equator. In this work, we statistically investigated the occurrences of postsunset ionospheric E, valley, and F region irregularities, the postsunset rise of F layer, and their correlations by using the Sanya (18.4°N, 109.6°E, dip latitude 12.8°N) very high frequency radar and ionosonde observations during equinoctial months of 2012-2016. A statistically significant correlation between the presence of valley region irregularities and that of equatorial spread F (ESF) was found over Sanya. For the days without ESF, valley region irregularity was rarely observed. The Doppler velocities of valley region irregularities were mainly upward which resemble those of simultaneous ESF irregularities. On the other hand, an occurrence peak of E region irregularities was detected around sunset. After sunset, E region irregularity echo was frequently disrupted. The disruption can appear on both ESF and non-ESF days, when the amplitudes of F layer postsunset rise were significantly different. The effects of polarization electric field associated with ESF and of equatorial ionospheric background condition on the E and valley region irregularities over Sanya are discussed.