First trimester neutrophil to lymphocyte ratio (NLR) and pregnancy outcome

Christoforaki, Viktoria; Daskalakis, Georgios; Katasos, Theodoros; Siristatidis, Charalambos

doi:10.1080/01443615.2019.1606171

Cited by 43 publications

(41 citation statements)

References 34 publications

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“…NLR has been shown to correlate with cardiovascular disease, neoplasm, and metabolic syndrome as well as pre-eclampsia, gestational diabetes mellitus, and miscarriage. [7][8][9][10][11] In addition to NLR, several other hematological markers such as platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW) were found to correlate with inflammatory states. 12,13 Disorders in placentation and placental secretions have been related to pregnancy disorders and poor outcomes, 14,15 including ischemic conditions resulting in uteroplacental insufficiency that may stimulate unbalanced release of placental hormones, cytokines, and growth factors.…”

Section: Introductionmentioning

confidence: 99%

“…Neutrophil‐to‐lymphocyte ratio (NLR) is a well‐established hematological marker of systemic inflammation and may represent a pro‐inflammatory state. NLR has been shown to correlate with cardiovascular disease, neoplasm, and metabolic syndrome as well as pre‐eclampsia, gestational diabetes mellitus, and miscarriage 7‐11 . In addition to NLR, several other hematological markers such as platelet‐to‐lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW) were found to correlate with inflammatory states 12,13 …”

Section: Introductionmentioning

confidence: 99%

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Early predictors of small‐for‐gestational‐age neonates using non‐invasive, low‐cost, and readily available hematological markers

Levy

Pariente

Rotem

et al. 2020

Intl J Gynecology & Obste

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Objective: To evaluate whether neutrophil-to-lymphocyte ratio (NLR), a well-established inflammatory marker, can be used as an early predictor for small-for-gestationalage (SGA) neonates and other adverse pregnancy outcomes. Methods: A case-control study compared first-trimester hematological biomarkers in pregnancies of patients with and without SGA (n=149, n=151, respectively). Demographic, clinical, and obstetrical characteristics and first-trimester complete blood count were retrieved. Woman with singleton pregnancies who delivered at Soroka University Medical Center between January 2015 and December 2016 were included. Patients with known maternal infections, relevant medications, hematological conditions, and chronic diseases that may alter the blood count, those with multiple pregnancies, and those with congenital or chromosomal abnormalities were excluded. After univariate analysis, a linear regression model was constructed to assess the association between hematological indices and SGA. Receiver operating curves were constructed to evaluate the sensitivity and specificity of NLR. Results: First-trimester NLR values of the SGA group were significantly higher compared to controls (3.03 ± 1.68 vs 2.63 ± 1.2, P=0.016). Significantly higher levels of NLR were noted among the severely (<3%) SGA neonates (3.12 ± 1.62 vs 2.62 ± 1.2; P=0.034). Conclusion: NLR may be an early, clinically useful marker in the prediction of SGA. As blood samples are routinely collected, correct implication of this result may serve as a valuable non-invasive, low-cost, readily available predicting tool.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early predictors of small‐for‐gestational‐age neonates using non‐invasive, low‐cost, and readily available hematological markers

Levy

Pariente

Rotem

et al. 2020

Intl J Gynecology & Obste

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“…However, there are few studies investigating the association between NLR and PLR values and early pregnancy loss. In a study by Christoforaki et al, it was found that NLR does not differ significantly between pregnant women with live birth and those whose pregnancy ended in miscarriage [25]. In contrast, in the study of Bas et al, NLR and PLR values evaluated at the sixth gestational week can be used for the risk assessment of spontaneous abortion.…”

Section: Discussionmentioning

confidence: 96%

Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss?

Oğlak

Aydın

2020

Ginekol Pol

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Objectives: Red cell distribution width (RDW), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have all been identified as systemic inflammatory markers. The aim of this study to investigate whether the use of systemic inflammatory markers can predict early pregnancy loss. Material and methods: A total of 137 patients with early pregnancy loss was compared with 148 participants in the control group who had given birth at term. In the study group, CBC values were included in the study at the time of referral to the hospital for routine follow-up, while patients did not experience early pregnancy loss. In the control group, CBC values of the patient before the seventh week of pregnancy were included in the study. results: There was no significant difference between the two groups in terms of RDW, MPV, PCT and PDW values. The NLR and PLR values were significantly higher in the early pregnancy loss group than the control group (p < 0.05). Conclusion: Our findings suggest that high NLR and PLR values are potent markers for the prediction of early pregnancy loss.

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“…However, the lymphocyte count was lower in the group with LGA. Christoforaki et al [25] have compared first trimester NLR and PLR rates with pregnancy outcomes and found no relationship between those parameters and birth weights; however, Akgün et al [26] have found a negative correlation between PLR and birth weight. They reported that NLR was not related with birth weight.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of third-trimester neutrophil-lymphocyte and platelet-lymphocyte ratios and their correlation with birth weight

Kirlangic¹,

Sade²,

Vural³

et al. 2021

Journal of Surgery and Medicine

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First trimester neutrophil to lymphocyte ratio (NLR) and pregnancy outcome

Cited by 43 publications

References 34 publications

Early predictors of small‐for‐gestational‐age neonates using non‐invasive, low‐cost, and readily available hematological markers

Early predictors of small‐for‐gestational‐age neonates using non‐invasive, low‐cost, and readily available hematological markers

Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss?

Evaluation of third-trimester neutrophil-lymphocyte and platelet-lymphocyte ratios and their correlation with birth weight

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