Fish Intake in Pregnancy and Child Growth

Stratakis, Nikos; Roumeliotaki, Theano; Oken, Emily; Barros, Henrique; Basterrechea, Mikel; Munier, Charles; Eggesbø, Merete; Forastiére, Francesco; Gaillard, Romy; Gehring, Ulrike; Govarts, Eva; Hanke, Wojciech; Heude, Barbara; Iszatt, Nina; Jaddoe, Vincent W. V.; Kelleher, Cecily; Mommers, Monique; Murcia, Mario; Oliveira, Andréia; Pizzi, Costanza; Polańska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Rifas‐Shiman, Sheryl L.; Schoeters, Greet; Sunyer, Jordi; Thijs, Carel; Viljoen, Karien; Vrijheid, Martine; Vrijkotte, Tanja G. M.; Wijga, Alet H.; Kogevinas, Manolis; Chatzi, Leda

doi:10.1001/jamapediatrics.2015.4430

Cited by 45 publications

(27 citation statements)

References 32 publications

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“…24 The KANC cohort had no information on maternal diet and was therefore not included in our analysis. As in previous work, 25 we categorized fish intake into low (<1 time per week), moderate (1-3 times per week, consistent with recommendations from the US Food and Drug Administration and the Environmental Protection Agency), 26 and high (>3 times per week).…”

Section: Fish Intake and Mercury Concentrationmentioning

confidence: 99%

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

et al. 2020

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IMPORTANCE The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown.OBJECTIVE To assess the associations of fish intake and mercury exposure during pregnancy with metabolic syndrome in children and alterations in biomarkers of inflammation in children. DESIGN, SETTING, AND PARTICIPANTSThis population-based prospective birth cohort study used data from studies performed in 5 European countries (France, Greece, Norway, Spain, and the UK) between April 1, 2003, and February 26, 2016, as part of the Human Early Life Exposome (HELIX) project. Mothers and their singleton offspring were followed up until the children were aged 6 to 12 years. Data were analyzed between March 1 and August 2, 2019.EXPOSURES Maternal fish intake during pregnancy (measured in times per week) was assessed using validated food frequency questionnaires, and maternal mercury concentration (measured in micrograms per liter) was assessed using maternal whole blood and cord blood samples. MAIN OUTCOMES AND MEASURESAn aggregate metabolic syndrome score for children was calculated using the z scores of waist circumference, systolic and diastolic blood pressures, and levels of triglyceride, high-density lipoprotein cholesterol, and insulin. A higher metabolic syndrome score (score range, −4.9 to 7.5) indicated a poorer metabolic profile. Three protein panels were used to measure several cytokines and adipokines in the plasma of children. RESULTSThe study included 805 mothers and their singleton children. Among mothers, the mean (SD) age at cohort inclusion or delivery of their infant was 31.3 (4.6) years. A total of 400 women (49.7%) had a high educational level, and 432 women (53.7%) were multiparous. Among children, the mean (SD) age was 8.4 (1.5) years (age range, 6-12 years). A total of 453 children (56.3%) were boys, and 734 children (91.2%) were of white race/ethnicity. Fish intake consistent with health recommendations (1 to 3 times per week) during pregnancy was associated with a 1-U decrease in metabolic syndrome score in children (β = −0.96; 95% CI, −1.49 to −0.42) compared with low fish consumption (<1 time per week) after adjusting for maternal mercury levels and other covariates. No further benefit was observed with fish intake of more than 3 times per week. A higher maternal mercury concentration was independently associated with an increase in the metabolic syndrome score of their offspring (β per 2-fold increase in mercury concentration = 0.18; 95% CI, 0.01-0.34).Compared with low fish intake, moderate and high fish intake during pregnancy were associated with reduced levels of proinflammatory cytokines and adipokines in children. An integrated analysis identified a cluster of children with increased susceptibility to metabolic disease, which was (continued) Key Points Question Is fish consumption during pregnancy associated with benefits for the metabolic health of children? Findings In this cohort study of 805 mothers and their singleton offspring, ...

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Section: Fish Intake and Mercury Concentrationmentioning

confidence: 99%

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

et al. 2020

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“…Анализ объединенных данных, опубликованный в 2016 г., посвящен оценке корреляции приема в пищу рыбы матерями во время беременности и позднее -детьми с развитием пищевой аллергии в дальнейшем [25]. Были проанализированы одно рандомизированное контролируемое исследование и 17 публикаций, объеди-нивших результаты 13 проспективных когортных иссле-дований.…”

Section: вопросы современной педиатрииunclassified

“…При этом прием в пищу рыбы беременными женщинами не оказывал значимого влияния на форми-рование сенсибилизации и развитие таких состояний и заболеваний, как пищевая аллергия, атопический дер-матит, аллергический ринит, свистящие хрипы у детей младшего возраста. Однако авторы отметили наличие ограничений и высокий риск систематических ошибок в проанализированных материалах, в частности значи-мую гетерогенность оценок результатов в исследовани-ях, использование различных типов опросников, риск «дозозависимого» эффекта и т. д. Несомненно, что для подтверждения возможного профилактического эффекта раннего введения рыбы в рацион ребенка необходимы новые исследования более высокого качества [25].…”

Section: вопросы современной педиатрииunclassified

Introduction of Complementary Foods and Food Allergies: New Studies and Modern Clinical Guidelines

Намазова-Баранова¹,

Вишнёва²,

Селимзянова³

et al. 2017

Vopr. sovr. pediatr.

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“…Several recent children’s health pooled analyses, addressing a wide variety of exposure-outcome associations, have been published [11–15]. Each of these pooled analyses have identified strengths and limitations encountered through the use of this approach.…”

Section: Introductionmentioning

confidence: 99%

Big and disparate data: considerations for pediatric consortia

Stingone

Mervish

Kovatch

et al. 2017

Current Opinion in Pediatrics

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Purpose of the review Increasingly, there is a need for examining exposure disease associations in large, diverse datasets to understand the complex determinants of pediatric disease and disability. Recognizing that children’s health research consortia will be important sources of big data, it is crucial for the pediatric research community to be knowledgeable about the challenges and opportunities that they will face. This review will provide examples of existing children’s health consortia; highlight recent pooled analyses conducted by children’s health research consortia; address common challenges of pooled analyses and provide recommendations to advance collective research efforts in pediatric research. Recent findings Formal consortia and other collective-science initiatives are increasingly being created to share individual data from a set of relevant epidemiological studies to address a common research topic. There are practical challenges to the participation of investigators within consortia that need to be addressed, including providing centralized data management, addressing barriers to data sharing and harmonization of data across studies and respecting the data ownership of original investigators. Summary Researchers who access consortia with data centers will be able to go far beyond their initial hypotheses and potentially accomplish research that was previously thought infeasible or too costly.

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Fish Intake in Pregnancy and Child Growth

Cited by 45 publications

References 32 publications

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

Introduction of Complementary Foods and Food Allergies: New Studies and Modern Clinical Guidelines

Big and disparate data: considerations for pediatric consortia

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