Fish oil–rich lipid emulsion modulates neuroinflammation and prevents long-term cognitive dysfunction after sepsis

Giustina, Amanda Della; Danielski, Lucinéia Gainski; Florentino, Drielly; Garbossa, Leandro; Joaquim, Larissa; Oliveira, Aloir Neri de; Mathias, Khiany; Fileti, Maria Eduarda; Zarbato, Graciela Freitas; Rosa, Naiana da; Laurentino, Ana Olívia Martins; Fortunato, Jucélia Jeremias; Palandi, Juliete; Oliveira, Bruna Hoffmann de; Martins, Daniel Fernandes; Bonbinski, Franciane; Bellettini-Santos, Tatiani; Garcez, Michelle Lima; Budni, Josiane; Barichello, Tatiana; Petronilho, Fabrícia

doi:10.1016/j.nut.2018.12.003

Cited by 24 publications

(10 citation statements)

References 93 publications

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“…9 Late beneficial central nervous system effects of fish oil ILE seen after hospitalization for sepsis may be relevant to patients with severe COVID-19. 10 We concur with Marone and Rinaldi that further attention to the problem of DVT in SARS-CoV-2 patients is needed. Preliminary recommendations exist regarding the use of heparin derivatives and other drugs with hemostatic effects in the management of these patients.…”

Section: Fish Oil and Covid-19 Thrombosessupporting

confidence: 66%

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Fish oil and COVID-19 thromboses

Merritt¹,

Bhardwaj²,

Jami³

2020

Journal of Vascular Surgery: Venous and Lymphatic Disorders

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Fish Oil and Covid-19 Thrombosessupporting

confidence: 66%

“… 9 Late beneficial central nervous system effects of fish oil ILE seen after hospitalization for sepsis may be relevant to patients with severe COVID-19. 10 …”

mentioning

confidence: 99%

Fish oil and COVID-19 thromboses

Merritt¹,

Bhardwaj²,

Jami³

2020

Journal of Vascular Surgery: Venous and Lymphatic Disorders

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“…BDNF is one of the neurotrophic factors that are expressed widely in the brain, regulating neuronal survival, synaptic transmission, synaptic plasticity, and learning and memory ( Song et al, 2017 ). Della Giustina et al (2020) found that BDNF was remarkably decreased on day 10 after sepsis induction in rats, and those animals displayed a severe cognitive impairment. Pang et al (2004) reported that BDNF supported neuronal survival, long-term potentiation, and learning and memory.…”

Section: Discussionmentioning

confidence: 94%

“…Studies indicated that the downregulation of neurotrophic factors, especially BDNF, plays an important role in cognitive impairment and neurodegeneration (Fleitas et al, 2018;Caffino et al, 2020). BDNF is one of the neurotrophic factors that are expressed widely in the brain, regulating neuronal survival, synaptic transmission, synaptic plasticity, and learning and memory (Song et al, 2017). Della Giustina et al (2020 found that BDNF was remarkably decreased on day 10 after sepsis induction in rats, and those animals displayed a severe cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy

et al. 2021

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Sepsis-associated encephalopathy (SAE) is a risk factor for cognitive and memory dysfunction; however, the mechanism remains unclear. Brain-derived neurotrophic factor (BDNF) was reported to have a positive effect on cognition and emotion regulation, but the study of its precursor, proBDNF, has been limited. This study aimed to elucidate the effects and associated mechanisms of hippocampal proBDNF in a lipopolysaccharide (LPS)-induced SAE mouse model. In this study, we found that the mice exhibited cognitive dysfunction on day 7 after LPS injection. The expression of proBDNF and its receptor, p75NTR, was also increased in the hippocampus, while the levels of BDNF and its receptor, TrkB, were decreased. A co-localization study showed that proBDNF and p75NTR were mainly co-localized with neurons. Furthermore, LPS treatment reduced the expression of NeuN, Nissl bodies, GluR4, NR1, NR2A, and NR2B in the hippocampus of SAE mice. Furthermore, an intrahippocampal or intraperitoneal injection of anti-proBDNF antibody was able to ameliorate LPS-induced cognitive dysfunction and restore the expression of NeuN, Nissl bodies, GluR4, NR1, NR2A, NR2B, and PSD95. These results indicated that treatment with brain delivery by an intrahippocampal and systemic injection of mAb-proBDNF may represent a potential therapeutic strategy for treating patients with SAE.

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“…Fish eggs are rich in all nutrients required for embryo development and many biologically active substances, including docosahexaenoic acid, eicosapentaenoic acid, lecithin and glycoproteins [1,2]. Furthermore, fish eggs have been reported to be able to improve memory [3], alleviate metabolic syndrome [4] and inhibit osteoclastogenesis [5]. However, high-value utilization of fish eggs is yet to be fully developed.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of a Novel Sialoglycopeptide Promoting Osteogenesis from Gadus morhua Eggs

et al. 2019

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Gadus morhua eggs contain several nutrients, including polyunsaturated fatty acids, lecithin and glycoproteins. A novel sialoglycopeptide from the eggs of G. morhua (Gm-SGPP) was extracted with 90% phenol and purified by Q Sepharose Fast Flow (QFF) ion exchange chromatography, followed by S-300 gel filtration chromatography. Gm-SGPP contained 63.7% carbohydrate, 16.2% protein and 18.6% N-acetylneuraminic acid. High-performance size exclusion chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) demonstrated that Gm-SGPP is a 7000-Da pure sialoglycopeptide. β-elimination reaction suggested that Gm-SGPP contained N-glycan units. Amino acid N-terminal sequence analysis indicated the presence of Ala-Ser-Asn-Gly-Thr-Gln-Ala-Pro amino acid sequence. Moreover, N-glycan was connected at the third Asn location of the peptide chain through GlcNAc. Gm-SGPP was composed of D-mannose, D-glucuronic acid and D-galactose. Fourier transform-infrared spectroscopy (FT-IR), 1H-nuclear magnetic resonance spectroscopy (1H-NMR) and methylation analysis were performed to reveal the structure profile of Gm-SGPP. In vitro results showed that the proliferation activity of MC3T3-E1 cells was significantly promoted by Gm-SGPP. In vivo data revealed that Gm-SGPP increased the calcium and phosphorus content of tibias and promoted longitudinal bone growth in adolescent rats.

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Fish oil–rich lipid emulsion modulates neuroinflammation and prevents long-term cognitive dysfunction after sepsis

Cited by 24 publications

References 93 publications

Fish oil and COVID-19 thromboses

Fish oil and COVID-19 thromboses

Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy

Isolation and Characterization of a Novel Sialoglycopeptide Promoting Osteogenesis from Gadus morhua Eggs

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