Fixed drug eruption and generalised erythema following etoricoxib

Augustine, Mary; Sharma, Pooja; Stephen, John; Jayaseelan, Elizabeth

doi:10.4103/0378-6323.26732

Cited by 18 publications

(12 citation statements)

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“…Etoricoxib is a highly selective COX‐2 inhibitor exhibiting an increased cutaneous and systemic safety profile compared with the previous COX‐2 inhibitors . However, cutaneous side effects can occur occasionally, including ecchymoses, facial edema, rash, erythema multiforme, and acute generalized exanthematous pustulosis …”

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confidence: 99%

Etoricoxib‐induced toxic epidermal necrolysis

Moutran¹,

Maatouk

Hélou

2013

Int J Dermatology

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confidence: 99%

Etoricoxib‐induced toxic epidermal necrolysis

Moutran¹,

Maatouk

Hélou

2013

Int J Dermatology

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“…Until now no cross-reactivity has been described between these molecules possibly due to differences in the molecular structure of etoricoxib. 5,7,10 However, more data are still required before assuming the absence of cross-reactivity between different COX2 inhibitors.…”

Section: Figure 1 Patch Test With Etoricoxib (48 H Reading)mentioning

confidence: 99%

Fixed drug eruption due to etoricoxibe – A case report

Antunes¹,

Prates²,

Leiria-Pinto³

2014

Allergologia et Immunopathologia

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“…4 The mainstay of treatment for FDEs is withdrawal of the drug. 1,5 Although local steroids and/or emollients may be used, systemic therapy is usually not needed. 5 In general, FDEs are easy to diagnose if the presenting features are typical.…”

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confidence: 99%

“…1 Usually, the lesions are limited to a small area of the skin or mucosa. 2 However, extensive FDEs have been reported with nonsteroidal anti-inflammatory drugs (NSAIDs), lamotrigine and antibiotics such as vancomycin.…”

Section: Commentmentioning

confidence: 99%

“…Sometimes, FDEs may not occur on initial use of the drug and manifest only after a certain dose is attained. 1 Nonetheless, drug rechallenge is not always ethically possible; a skin biopsy is therefore sufficient to diagnose the condition at first onset. 2 With diclofenac, various cutaneous reactions can occur after oral or parenteral administration, including anaphylactic reactions, urticaria, exanthema and FDEs.…”

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confidence: 99%

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Extensive Fixed Drug Eruption Due to Diclofenac

Paul

Lahiri

et al. 2017

SQUMJ

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A 46-year-old male construction worker was admitted to a clinic in Kolkata, India, in 2016 with a sudden-onset black rash appearing in patches all over his body. He had sprained his left foot two days previously for which he was prescribed oral diclofenac tablets at a dose of 50 mg three times a day. He had taken three doses of the drug before noticing the skin lesions; however, he continued taking the drug due to the pain and presented to the clinic on the third day when the lesions became extensive. He was not currently taking any other drugs and had no history of similar skin lesions.On examination, the patient was noted to have darkly pigmented patches on his trunk and both the upper and lower limbs [ Figure 1]. The patches covered more than 50% of his body surface and were nonpruritic and non-tender, with sharply demarcated margins and surrounding erythema. No evidence of mucosal lesions or hair or nail changes was seen. The patient was treated with local emollients and a steroid cream. A skin biopsy revealed interface dermatitis with vacuolar changes. The patient was diagnosed with a fixed drug eruption (FDE) caused by the diclofenac. After 10 days, the patches became scaly and started to desquamate [ Figure 2].

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Fixed drug eruption and generalised erythema following etoricoxib

Cited by 18 publications

References 0 publications

Etoricoxib‐induced toxic epidermal necrolysis

Etoricoxib‐induced toxic epidermal necrolysis

Fixed drug eruption due to etoricoxibe – A case report

Extensive Fixed Drug Eruption Due to Diclofenac

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