Flavonoid Dietetics: Mechanisms and Emerging Roles of Plant Nutraceuticals

Parihar, Arti; Grotewold, Erich; Doseff, Andrea I.

doi:10.1007/978-1-4939-2356-4_5

Cited by 11 publications

(10 citation statements)

References 264 publications

(144 reference statements)

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“…The health benefits of flavonoids have been attributed to a number of biological activities, including anti-tumor, anti-metastatic and anti-inflammatory. Flavonoids also act as signaling molecules modulating cell growth, inducing apoptosis, and reducing reactive oxygen species production, presenting potential alternative approaches for treatment and prevention of cancer [54]. The position of the double bond in flavanones was found to inhibit the activity of the breast cancer resistance protein (BCRP) [55].…”

Section: Flavonoids Chemical Structure and Function: From Plants Tmentioning

confidence: 99%

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

2019

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Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and estrogenic activities. Numerous cellular and animal-based studies show that flavonoids can function as antioxidants by preventing DNA damage and scavenging reactive oxygen radicals, inhibiting formation of DNA adducts, enhancing DNA repair, interfering with chemical damage by induction of Phase II enzymes, and modifying signaling pathways. Recent evidence also shows their ability to regulate the immune system. However, findings from clinical trials have been mixed with no clear consensus on dose, frequency, or type of flavonoids best suited to elicit many of the beneficial effects. Delivery of these bioactive compounds to their biological targets through “targeted designed” food processing strategies is critical to reach effective concentration in vivo. Thus, the identification of novel approaches that optimize flavonoid bioavailability is essential for their successful clinical application. In this review, we discuss the relevance of increasing flavonoid bioavailability, by agricultural engineering and “targeted food design” in the context of the immune system and cancer.

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Section: Flavonoids Chemical Structure and Function: From Plants Tmentioning

confidence: 99%

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

2019

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“…Naturally synthesized pigments emerged as a promising source in the food sector as food colourings and in the health industry as amazing antioxidants due to their free radical scavenging actions (Sakuta, 2014). Moreover, these pigments are also gaining considerable attention as nutraceuticals and are used as health supplements for disease prevention (Parihar et al, 2015). Plant pigments can be classified into several classes such carotenoids, tetrapyrrole, phenolics, flavonoids and alkaloids (Tanaka et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Analysis of bioactive pigments in coloured callus of Azadirachta indica for possible use as functional natural colourants

Ashokhan

Srinivasan

Karsani

et al. 2019

PRT

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“…Their health benefits have been associated with the flavonoids’ anti-tumor, anti-metastatic and anti-inflammatory activities. In addition, flavonoids act as signaling molecules modulating cell growth, inducing apoptosis, reducing ROS production and presenting potential alternatives for the prevention of cancer [ 51 ]. Worldwide, there is a variation in the quantity and types of flavonoids consumed and the intake of dietary flavonoids is between 50 and 400 mg/day [ 52 ].…”

Section: Polyphenolsmentioning

confidence: 99%

Recent Advances in Phenolic Metabolites and Skin Cancer

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Diaconeasa

2021

IJMS

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Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effective in the chemoprevention of skin cancer is emphasized. This review focuses on melanoma because it is the deadliest form of skin cancer, with a significantly increasing incidence in the last decades. As chemopreventive agents, we present polyphenols and their antioxidant activity, anti-inflammatory effect, their ability to balance the cell cycle and to induce apoptosis and their various other effects on skin melanoma. Besides chemoprevention, studies suggest that polyphenols can have treating abilities in some conditions. The limitations of using polyphenols are also pointed out, which are related to their poor bioavailability and stability, but as the technology is well developed, it is possible to augment the efficacy of polyphenols in the case of melanoma.

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Flavonoid Dietetics: Mechanisms and Emerging Roles of Plant Nutraceuticals

Cited by 11 publications

References 264 publications

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

Analysis of bioactive pigments in coloured callus of Azadirachta indica for possible use as functional natural colourants

Recent Advances in Phenolic Metabolites and Skin Cancer

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