Flavonoids as complementary medicine for allergic diseases: current evidence and future prospects

Tanaka, Toshio

doi:10.13172/2052-7845-1-2-589

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…The action of anti-allergic agents is to prevent the relief of mediators of inflammation or inhibit the functions [24] . Flavonoids are natural products that have antioxidant, antiinflammatory, anti-allergic functions, and immunemodulating effects used as complementary and alternative medicine (25) . The anti-hyperglycemic and anti-allergic effects of B. tersa may be because of the availability of bioactive phytochemicals such as flavonoids, alkaloids, and tannins.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from <em>Brownlowia tersa</em> (L.) stem

Chakrabarty¹,

Kundu²,

Acharyya³

et al. 2022

J. Med. Plants Stud.

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Brownlowia tersa (L.) (Family: Malvaceae), has been used traditionally to treat inflammation, pain, diarrhea, allergic reaction etc. The aim of the recent study is to investigate the ethanolic extract of Brownlowia tersa (L.) stem for its anti-hyperglycemic and anti-allergic activity as well as to identify the phytochemicals constituents. Blood glucose level in mice, in anti-hyperglycemic activity, evaluated by OGTT (oral glucose tolerance test) considerably reduced by the extract at both dose 250 and 500 mg/kg b. wt. The extract also decreased significantly the allergic-like symptoms like sneezing, scratching, and nasal score induced by TDI in mice model. The count of WBC (total and differential) in both blood and Bronchoalveolar lavage (BAL) fluid were also reduced in the extract treated group. In qualitative phytochemical investigation, existence of different bioactive phytochemicals like alkaloids, flavonoids, steroids and tannins were observed. So the investigation suggests the anti-hyperglycemic and antiallergic activity of B. tersa stem extract due to the availability of one or more active metabolites in it.

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Section: Discussionmentioning

confidence: 99%

Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from <em>Brownlowia tersa</em> (L.) stem

Chakrabarty¹,

Kundu²,

Acharyya³

et al. 2022

J. Med. Plants Stud.

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“…However, systematic report regarding the presence of flavonoids in M. pachycarpa is lacking. Flavonoid have been found to be of great medicinal value in humans as they have been found to act as antiallergic, antiatherosclerotic, antioxidants, antifungal, antimutagenic, antithrombogenic, anti-inflammatory, antiviral antiosteoporotic, cardioprotective and radioprotective in several studies [43][44][45][46][47][48][49][50][51][52][53][54][55]. The flavonoids also stimulate signaling pathways required for various activities in the cells [56].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

M¹,

J²

2015

Saha, J Plant Biochem Physiol

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The humans have used medicinal plants for healthcare since the time immemorial. The systematic phytochemical analysis of traditionally used medicinal plants is needed to establish their use as medicine. Oroxylum indicum and Milletia pachycarpa have been used in India and China to treat various health related disorders. Therefore it was decided to undertake phytochemical and Thin Layer Chromatography (TLC) profiling of different extracts of Oroxylum indicum and Milletia pachycarpa using standard procedures. The dried powder of stem bark of Oroxylum indicum and root bark of Milletia pachycarpa was sequentially extracted in chloroform, ethanol and water. The dried extract of each plant was phytochemically analyzed for the presence of alkaloids, flavonoids, cardiac glycosides, phytosterols, saponins, tannins steroids and phlobatannins. Each extract from both plants was processed for TLC profiling on silica gel using various solvent combinations as mobile phase. The phytochemical analysis showed the presence of alkaloids in chloroform and ethanol extracts, whereas alkaloids were absent in aqueous extract of both Oroxylum indicum and Milletia pachycarpa. The flavonoids were observed in all extracts of both plants. However, cardiac glycosides were absent in the aqueous extract of Milletia pachycarpa. The saponins were detected in all the extracts of both plants except the chloroform extract of Oroxylum indicum. The tannins could not be detected in the aqueous extract of M. pachycarpa. The phlobatannins were absent in all extracts of both plants. Steroids exhibiting a wide variety of biological activity [8]. Almost every part of this tree possesses medicinal properties and has been used in several traditional Ayurvedic and folk medicines [18]. O. Indicum has been reported to possess several medicinal properties including analgesic, antibacterial, anti-inflammatory, anticancer, antioxidant [19][20][21][22][23]. Therefore, an attempt has been made to study the phytochemical constituents of Milletia pachycarpa and Oroxylum indicum. Materials and Methods Preparation of the extractThe non-infected stem bark of O. indicum was collected from Champhai whereas root bark of Milletia pachycarpa was collected from Kolasib district of Mizoram, India during the dry season in the month of January. The identification of plant was done by the Department of Horticulture and Aromatic and Medicinal Plants, Mizoram University, Aizawl, India. The barks of both plants was washed thoroughly with clean water and allowed to shade dry at room temperature in the dark in clean and hygienic conditions. The dried barks of both plants were separately powdered using an electrical grinder at room temperature. The powdered bark of O. indicum stem or root bark of M. pachycarpa was sequentially extracted with petroleum ether, chloroform, ethanol and distilled water according to increase in polarity using a Soxhlet apparatus until the solvents became colourless [24]. The liquid extracts were concentrated by evaporating their liquid contents using ...

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“…In addition, there are currently insufficient techniques for quantifying oxidative damage in vivo, and measuring objective endpoints is still challenging. To enable the collection of further information on the long-term consequences of consuming flavonoids on excretion and absorption and are particularly limited -better analytical techniques are required [85,86]. As above mentioned, flavonoids are the primary food source of human beings in their food such as veggies and tea.…”

Section: Implications For the Futurementioning

confidence: 99%

Flavanoids: An Era of Nutraceuticals Turning in to Medicinal Agents

PENTU,

2024

Asian J Pharm Clin Res

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Flavonoids, present in plants, constitute a varied group of naturally occurring compounds well-known for their potential positive effects on health. These molecules present in fruits, vegetables, and beverages such as tea exhibit antioxidant, anti-inflammatory, and other bioactive properties that contribute to their positive impact on human health. In addition, flavonoids act as antioxidants, helping plants combat oxidative stress. Some flavonoids also participate in ultraviolet protection, defense against pathogens, and modulation of plant-microbe interactions. Flavonoids have a different subclass of flavones, flavonols, flavanones, flavan-3-ols, anthocyanins, and isoflavones. The term “bioavailability” describes how well the body absorbs and uses flavonoids, a broad class of plant-based chemicals. The chemical structure of flavonoids, the matrix of foods they are eaten interactions with other dietary components influence their bioavailability. This metabolism can lead to the formation of various metabolites, impacting the compounds’ bioactivity. Understanding these aspects is crucial for unlocking the full potential of flavonoids in promoting health and preventing diseases. Patents on flavonoids serve as legal protections for innovations related to these plant compounds. Companies and researchers seek patents to safeguard novel methods of extraction, synthesis, and applications ensuring exclusivity for a specified period. This exclusivity incentivizes investment in research and development, promoting the exploration of flavonoids for pharmaceuticals, food additives, and cosmetics. Ultimately, these legal protections encourage advancements in understanding and harnessing the diverse benefits of flavonoids across various industries.

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Flavonoids as complementary medicine for allergic diseases: current evidence and future prospects

Cited by 8 publications

References 26 publications

Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from <em>Brownlowia tersa</em> (L.) stem

Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from <em>Brownlowia tersa</em> (L.) stem

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

Flavanoids: An Era of Nutraceuticals Turning in to Medicinal Agents

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