Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from &lt;em&gt;Brownlowia tersa&lt;/em&gt; (L.) stem

Chakrabarty, Brototi; Kundu, N. K.; Acharyya, Rabindra Nath; Khan, Asif; Islam, Md. Amirul; Dev, Shrabanti; Das, Asish Kumar

doi:10.22271/plants.2022.v10.i1a.1362

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…On the 21 st day, allergy like symptoms were measured. After 24 h. of provocation with TDI, mice were anesthetized by chloroform and blood samples were collected from vein by Chakrabarty et al, 2022 method [24] . Total WBC count was done on an automated cell counter.…”

Section: Differential Analysis In Bloodmentioning

confidence: 99%

Evaluation of toxicological, anti-allergic and neuropharmacological activities of Bridelia stipularis: In-vivo and in-silico studies

Acharyya¹,

Mitra²,

Risha³

et al. 2022

J. Med. Plants Stud.

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Bridelia stipularis locally known as 'Harinhara' native in hill tract area. The plant is traditionally used in cough, asthma and catarrh by the Chakma ethnic people of Bangladesh. In this study, we investigated the toxicological, anti-allergic, neuropharmacological potential of leaves extract and profiling of its bioactive polyphenols by HPLC for in-silico molecular docking. Phytochemical test confirmed the existence of phytochemicals including tannin, flavonoid, saponin, alkaloid, glycoside etc. In toxicity study, the extract was safe up to 3 g/kg oral dose in mice. The studied showed no organ specific toxicity at 500 mg/kg oral dose. Anti-allergic activity performed by using TDI-induced allergic mice model. The extract significantly reduced the TDI-induced allergy like symptoms such as scratching, sneezing, swelling (P < 0.05). Additionally, the extract also ameliorated the leukocytes count in blood and bronchoalveolar lavage (BAL) fluid. The neuropharmacological activity test was conducted by following the open field method in mice model, at both doses of extract at 300 and 500 mg/kg showed mild CNS depressant effect. HPLC profiling identified the presence of seven phenolic compounds, among these rutin hydrate demonstrated the best docking score of -7.4 kcal/mol same as anti-allergic drug against (H1R). On the other hand exhibited rosmarinic acid and myricetin -7.9 and -7.8 kcal/mol against GABAA whereas standard CNS drug showed -7.7 kcal/mol. In conclusion, B. stipularis is safe and rich in different polyphenolic compounds which were found effective against diseases.

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Section: Differential Analysis In Bloodmentioning

confidence: 99%

Evaluation of toxicological, anti-allergic and neuropharmacological activities of Bridelia stipularis: In-vivo and in-silico studies

Acharyya¹,

Mitra²,

Risha³

et al. 2022

J. Med. Plants Stud.

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Phytochemical Screening and Evaluation of Pharmacological Potential of Baliospermum solanifolium Leaf Extract

Mazumder,

Acharyya,

Kundu

et al. 2024

Clinical Complementary Medicine and Pharmacology

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Recent Advancement and Novel Application of Natural Polyphenols for the Treatment of Allergy Asthma: From Phytochemistry to Biological Implications

Kumari,

Siddiqui,

Gupta

2023

Crit Rev Immunol

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Allergic diseases, primarily IgE-mediated, exert a substantial global health burden. A pivotal role in allergic reactions is played by mast cells, with histamine serving as a central mediator. Within this context, plant-based polyphenols, abundantly present in vegetables and fruits, show promising potential for allergy prevention. These natural compounds, particularly flavonoids, possess anti-inflammatory and anti-allergic properties, influencing dendritic cells, modulating macrophages, and fostering the proliferation of B cells and T cells. The potent anti-allergic effects of flavonoids are attributed to their ability to reduce the production of signaling factors, suppress cytokine production, and regulate signal transduction and gene expression in mast cells, basophils, and T cells. Notably, their benefits extend beyond allergy prevention, as they hold promise in the prevention and treatment of autoimmune illnesses such as diabetes, rheumatoid arthritis, and multiple sclerosis. In the context of allergic reactions and autoimmune diseases, polyphenols exhibit immunomodulatory effects by inhibiting autoimmune T cell proliferation and downregulating pro-inflammatory cytokines. In recent times, flavonoids, being the most prevalent polyphenols in food, have garnered significant attention from researchers due to their potential health advantages. This review compiles the latest scientific research to highlight the impact of flavonoids on allergic illnesses and their potential as a beneficial dietary component.

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Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from <em>Brownlowia tersa</em> (L.) stem

Cited by 3 publications

References 17 publications

Evaluation of toxicological, anti-allergic and neuropharmacological activities of <em>Bridelia stipularis</em>: <em>In-vivo</em> and in-silico studies

Evaluation of toxicological, anti-allergic and neuropharmacological activities of <em>Bridelia stipularis</em>: <em>In-vivo</em> and in-silico studies

Phytochemical Screening and Evaluation of Pharmacological Potential of Baliospermum solanifolium Leaf Extract

Recent Advancement and Novel Application of Natural Polyphenols for the Treatment of Allergy Asthma: From Phytochemistry to Biological Implications

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