Flavonoids for Treating Viral Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis of 30 Randomized Controlled Trials

Yao, Jia; Zhang, Yuan; Wang, Xian-Zhe; Zhao, Jiuliang; Yang, Zhenjiang; Lin, Yuping; Sun, Lu; Lu, Qi-Yun; Fan, Guan-Jie

doi:10.3389/fpubh.2022.814669

Cited by 22 publications

(16 citation statements)

References 77 publications

(165 reference statements)

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“…Our meta-analysis of data from 26 preclinical animal studies showed that flavonoid supplementation could significantly increase the levels of anti-oxidative enzymes (SOD, CAT, GSH, GPx, and GST), reduce the production of oxidative agents (MDA) and pro-inflammatory mediators (NO, TNF-α, IL-6, IL-1β, CRP, IgG, VEGF, and MPO), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, FAS, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced ALT and AST activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17β-HSD, and reduced sperm abnormalities), and brain (enhanced AChE activities). Our conclusions were in line with previous meta-analyses that reported the protective roles of flavonoids on other oxidative stress- and inflammation-related diseases ( 11 , 45 ). These findings suggest that appropriate supplementation of flavonoids may be a potential measure to prevent occupational detriments resulting from nanomaterial exposure.…”

Section: Discussionsupporting

confidence: 93%

Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies

Xie

Wu³

et al. 2022

Front. Nutr.

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BackgroundNanomaterials, widely applied in various fields, are reported to have toxic effects on human beings; thus, preventive or therapeutic measures are urgently needed. Given the anti-inflammatory and antioxidant activities, supplementation with flavonoids that are abundant in the human diet has been suggested as a potential strategy to protect against nanomaterial-induced toxicities. However, the beneficial effects of flavonoids remain inconclusive. In the present study, we performed a meta-analysis to comprehensively explore the roles and mechanisms of flavonoids for animals intoxicated with nanomaterials.MethodsA systematic literature search in PubMed, EMBASE, and Cochrane Library databases was performed up to April 2022. STATA 15.0 software was used for meta-analyses.ResultsA total of 26 studies were identified. The results showed that flavonoid supplementation could significantly increase the levels of antioxidative enzymes (superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase), reduce the production of oxidative agents (malonaldehyde) and pro-inflammatory mediators (tumor necrosis factor-α, interleukin-6, IL-1β, C-reactive protein, immunoglobulin G, nitric oxide, vascular endothelial growth factor, and myeloperoxidase), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, Fas cell surface death receptor, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced alanine aminotransferase and aspartate aminotransferase activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17β-hydroxysteroid dehydrogenase type, and reduced sperm abnormalities), and brain (enhanced acetylcholinesterase activities). Most of the results were not changed by subgroup analyses.ConclusionOur findings suggest that appropriate supplementation of flavonoids may be effective to prevent the occupational detriments resulting from nanomaterial exposure.

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Section: Discussionsupporting

confidence: 93%

Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies

Xie

Wu³

et al. 2022

Front. Nutr.

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“…A total of 10 meta-analysis studies were included in this study, which evaluated liraglutide, semaglutide, and tirzepatide for the treatment of obesity [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Resultsmentioning

confidence: 99%

Impact of Nutrient-Stimulated Hormone (NUSH) Dynamics on Body Weight

Andrade,

de Oliveira,

de Oliveira

et al. 2024

Preprint

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Introduction: Nutrient-stimulated hormones (NUSH) play a critical role in regulating energy metabolism. Dysregulation of NUSH signaling is associated with obesity, there is a lack of quantitative models to investigate the complex dynamics of NUSH signaling and its impact on obesity development. Objective: To explore the relationship between NUSH and body weight using mathematical modeling. Methods: Data on elevated body weight were collected from meta-analysis studies available on Pubmed, utilizing incretin-based therapies. A mathematical model was developed using software to integrate interactions between NUSH levels and changes in body weight. The model accurately captured the complex dynamics and feedback loops involved in obesity-related hormonal regulation, employing differential equations and statistical techniques. Parameter estimation was performed using meta-analysis results to minimize the discrepancy between model predictions and observed data. Results: This study included 15 meta-analysis studies on liraglutide, semaglutide, and tirzepatide for the treatment of obesity. A mathematical model was developed to understand NUSH dynamics in relation to obesity. The model deduced the formula: NUSH(t) = N0 * (1 - e^(-kt)) + I * [1 - e^(-βt)] / β, which considers NUSH levels over time, initial levels, decay rate, impact of nutrient intake on hormone secretion, and the rate at which the effect of nutrient intake reaches its maximum. Conclusion: Evaluating the association between NUSH and increased body weight through mathematical modeling can provide insights into the complex interactions between nutrient stimuli, hormonal responses, and obesity development.

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“…Several studies investigated efficacy and safety of T&CM methods in the treatment of COVID 19 patients, including Chinese patent medicines Jing-Si Herbal Tea [ 48 ] and Lianhua Qingwen [ 49 ], flavonoids [ 50 ], and Ayurcov, a formulation made of ingredients mentioned in Ayurveda [ 51 ]. In addition, a retrospective study in Egypt included COVID 19 patients and their contacts who used TaibUVID nutritional supplement from prophetic medicine ( Nigella sativa , chamomile, and natural honey).…”

Section: Discussionmentioning

confidence: 99%

Use of traditional and complementary medicine for COVID 19 prophylaxis among healthcare professionals and students in Jordan: A cross-sectional study

Bulatova

Younes²,

Arabiyat³

et al. 2022

PLoS ONE

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Introduction There is inadequate evidence to recommend the use of any traditional and complementary medicine (T&CM) methods such as vitamin, mineral, herbal or other dietary supplements to prevent or treat COVID 19. Members of the medical team are particularly at risk of exposure to high viral load of coronavirus. They have also the best access to professional information regarding disease treatment and prophylaxis and disseminate such knowledge. The aim of the study was to assess the prevalence of use of T&CM for the prophylaxis of COVID 19 among the healthcare professionals and students in Jordan, along with the most common types and the factors associated with T&CM use. Methodology A cross-sectional study of T&CM use was conducted in Jordan using a snowball sampling method to distribute Google Forms and to enrol participants during coronavirus outbreak between June 10, 2021, and August 28, 2021. The study included healthcare professionals or students who consented to participate in the survey. The survey excluded those participants who had filled the questionnaire at least once or were pregnant/breast-feeding at the time of the study. The questionnaire consisted of 29 items, including screening, checkbox, dichotomous, matrix and open-ended questions. Results The response rate was 97.1%. Out of 560 study respondents, 359 (64.1%) reported using T&CM for COVID 19 prevention. Vitamins and nutrients were consumed by almost half (48.4%) of study participants, while nonpharmacological methods and herbal remedies were consumed by 35.2% and 25.2%, respectively. The most common source of information regarding T&CM use for COVID 19 prophylaxis included scientific publications (59.5%), followed by disease treatment guidelines (38.0%) and social media (32.3%). Adverse effects were reported by 8.5% and possible adverse effects were reported by another 8.5% of participants. The T&CM use was associated with working in contact with COVID 19 patients (OR: 1.625 (95% CI 1.047–2.523) (P = 0.03) and having a colleague as a source of information (OR: 1.720 (95% CI 1.026–2.883) (P = 0.04). Conclusions The prevalence of T&CM use for COVID 19 prevention among healthcare professionals and students in Jordan is high, with a significant proportion of participants reporting adverse effects. There is an urgent need for further research toward efficacy and safety of T&CM in COVID 19 prophylaxis as well as development of appropriate public health policy on this issue specific to each country.

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Flavonoids for Treating Viral Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis of 30 Randomized Controlled Trials

Cited by 22 publications

References 77 publications

Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies

Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies

Impact of Nutrient-Stimulated Hormone (NUSH) Dynamics on Body Weight

Use of traditional and complementary medicine for COVID 19 prophylaxis among healthcare professionals and students in Jordan: A cross-sectional study

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