Flavonoids with hepatoprotective activity from the leaves of <i>Cleome viscosa</i> L.

Phat, Nguyen Tan; Tran, Cong Luan; Vuong, Chi Hung; Do, Thi Hong Tuoi; Lê, Thạch Ngọc; Tri, Dinh; Phan, Nhat Minh

doi:10.1080/14786419.2017.1283497

Cited by 39 publications

(12 citation statements)

References 21 publications

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“…1,2 Cleome viscosa L. (Cleomaceae formerly Capparidaceae) commonly known as "wild or dog mustard, " is one such herb found all over the plains of India and throughout the tropics of the World. 3,4 It is an annual waste land weed with yellow flowers with sticky in nature and strong penetrating odour. In Indian traditional medicine, found throughout the greater part of roadsides, refuse heaps, waste grounds and agricultural land and waste places 5,6 the seeds are small, dark brown or black and granular, possessing rubefacient, vesicant and anthelminthic properties.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Structural Elucidation of Allantoin a Bioactive Compound from Cleome viscosa L.: A Combined Experimental and Computational Investigation

Lakshmanan¹,

Sivaraj²,

Ammar³

et al. 2019

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Allantoin, a crystalline compound was isolated from the methanolic extract of Cleome viscosa and it was reported for first time from this plant. The structure of Allantoin was elucidated by single crystal XRD and it was further confirmed through FTIR and ESI-MS spectroscopy techniques. It was crystallized in monoclinic crystal system with the space group P2i/c. Electronic structure characterization of the isolated Allantoin was done through density functional theory calculation. The atomic charges, dipole moment, frontier molecular orbital and the electrostatic potential map of the molecule in the gaseous phase and in the active site have also been analyzed. The optimized geometry was used for molecular docking to identify the possible binding mode. Furthermore, the in vitro antibacterial activity of the isolated Allantoin against Gram-positive and Gram-negative bacteria was evaluated. Maximum Inhibitory Concentrations (MIC) of isolated Allantoin results showed 4 µg/mL for B. subtilis and 8 µg/mL for S. aureus, E. coli and K. pneumoniae.

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Section: Introductionmentioning

confidence: 99%

Isolation and Structural Elucidation of Allantoin a Bioactive Compound from Cleome viscosa L.: A Combined Experimental and Computational Investigation

Lakshmanan¹,

Sivaraj²,

Ammar³

et al. 2019

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“…Similar results were achieved by Aikemu et al (2016), which described the preventive potential of a traditional herbal preparation rich in flavonoids in the reduction of liver weight promoted by 5-fluorouracil and doxorubicin in mice. However, it is relevant to point out that the liver weight is not a gold standard for assessing hepatotoxicity, but the hepatoprotective properties of B. forficata tea and kaempferitrin were already described by Salgueiro et al (2016) and by Nguyen et al (2017), respectively, reinforcing the hypothesis that FRF-BF can exert hepatoprotective actions against irinotecan.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid‐rich fraction of Bauhinia forficata Link leaves prevents the intestinal toxic effects of irinotecan chemotherapy in IEC‐6 cells and in mice

Cechinel-Zanchett

Boeing

Somensi

et al. 2018

Phytotherapy Research

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This study evaluated the effects of flavonoid-rich fraction from Bauhinia forficata leaves (FRF-BF), against intestinal toxicity induced by irinotecan. The leaves of this plant are used like tea in Brazilian folk medicine, and it is rich in flavonoids, mainly kaempferitrin.First, the chemopreventive effects of FRF-BF and kaempferitrin were evaluated in intestinal cells (IEC-6 cells) exposed to irinotecan. Next, the effects were evaluated against irinotecan-induced mucositis in mice. Lastly, melanoma was induced in C57BL/6 mice to evaluate FRF-BF interference on irinotecan antitumor activity. The results showed that FRF-BF and kaempferitrin exert no cytotoxic effects in IEC-6 cells and confirmed that pretreatment with FRF-BF and kaempferitrin displays chemoprotective effects against cytotoxicity induced by irinotecan. Interestingly, the FRF-BF (100 mg/kg, p.o) reduced the intestinal motility in mice and attenuated parameters linked to irinotecaninduced intestinal mucositis, including diarrhea, histological damage, depletion of duodenal GSH, amount of TNF-α, and MPO activity in the small intestine. Also, FRF-BF does not interfere in the antitumor activity of irinotecan and exerted antitumoral activity in murine melanoma. In conclusion, FRF-BF (100 mg/kg, p.o) presents promising pharmacological potential to prevent and attenuate the severity of intestinal mucositis during chemotherapy treatment, related to the presence of kaempferitrin.

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“…So far, there has been no report on the hepatoprotection and phytochemical constituents of the C. chelidonii and C. viscosa stems. Continuing our study on bioactive composition of traditional Vietnamese medicines [35] and the Cleome genus [36][37][38][39], this paper detailed the evaluation of the hepatoprotective effect of different extracts (n-hexane, ethyl acetate (EtOAc), and methanol (MeOH) extracts) from the stems of two Cleome species against CCl 4 -induced liver intoxication in both in vitro and in vivo assays. All compounds isolated from the most active extracts were also measured for the hepatoprotective activity using in vitro assay.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems

Phan

Nguyen

et al. 2021

Journal of Chemistry

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The study aims to determine the hepatoprotective effect of n-hexane, ethyl acetate, and methanol extracts of the leaves and stems of two Cleome species against carbon tetrachloride- (CCl4-) induced liver toxicity both in vitro using human hepatoma (HepG2) cells and in vivo in rats as well as the hepatoprotective property of all isolated compounds on HepG2. After 72 h of treatment, at the concentrations of 25, 50, and 100 μg/mL, the methanol of C. chelidonii stems (CCSM) ranged from 18.6% to 20.8%, whereas the methanol of C. chelidonii stems (CVSM) increased from 12.3% to 17.2% cell viability. The results show that CCSM and CVSM significantly expressed in vitro hepaprotective activity on HepG2. Therefore, the animals were daily treated with these extracts at the doses of 15, 30, and 45 mg/kg body weight for 5 days, and CCl4 was injected (2 ml/kg body weight, i.p.) on the 2nd and 3rd days. Levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST) in the blood were measured and compared to the silymarin control. The treatments with CCSM and CVSM (30, and 45 mg/kg) possessed significant hepatoprotection and were comparable with the activity of silymarin. Further, phytochemical studies of these ones were conducted and led to the identification of eight flavonoids: visconoside A (1), visconoside B (2), quercetin 3-O-β-D-glucopyranoside 7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-β-D-glucopyranoside 7-O-α-L-rhamnopyranoside (4), cleomeside A (5), cleomeside B (6), cleomeside C (7), and quercetin-3-O-[β-D-glucopyranosyl-(1⟶2)]-α-L-rhamnopyranoside 7-O-α-L-rhamnopyranoside (8). Two major flavonoids (1 and 4) displayed significant hepatoprotective property (at the concentration of 100 μM, the prevention percentage values were 66.5% and 74.2%, respectively, compared to the quercetin control, with value of 80.3%).

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Flavonoids with hepatoprotective activity from the leaves of Cleome viscosa L.

Cited by 39 publications

References 21 publications

Isolation and Structural Elucidation of Allantoin a Bioactive Compound from Cleome viscosa L.: A Combined Experimental and Computational Investigation

Isolation and Structural Elucidation of Allantoin a Bioactive Compound from Cleome viscosa L.: A Combined Experimental and Computational Investigation

Flavonoid‐rich fraction of Bauhinia forficata Link leaves prevents the intestinal toxic effects of irinotecan chemotherapy in IEC‐6 cells and in mice

Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems

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