natural skin, which has significant applications in wearable health care devices, intelligent robotics, implantable medical devices, and human-machine interfaces. [4][5][6][7] Different sensing mechanisms including capacitance, [8] piezoresistivity, [9] piezoelectricity, [10] and triboelectricity, [11] have mainly been used to convert external stimuli into electronic impulses for quantitative and spatial detection. Among them, piezoresistive effect has been widely used in the design and fabrication of tactile sensor due to the advantages of large detection, simple signal processing, and strong anti-interference capability. [12][13][14][15][16][17][18][19] Novel materials and structure have been applied in the design of high performance tactile sensors in recent researches. A hybrid 3D structure based on ultralight and superelastic MXene/ reduced graphene oxide aerogel is adopted to design a piezoresistive sensor by Yihua Gao etc., which exhibits the sensitivity of 22.56 kPa −1 , and limit detection (10 Pa). [20] Kai Pan's group reported a piezoresisitive pressure sensor based on aPANF/GA aerogel with a 3D interconnected hierarchical microstructure to monitor the real time movement of wrist pulse and main joints of human body. [21] Tactile sensors with high performance containing high sensitivity, wide detection range, fast response, flexibility, and mechanical durability are most concerned in the recent progress of e-skin. [22] Additionally, special functional properties such as self-healing, self-powered, biodegradable, biocompatible, and Resistive pressure sensors have been widely studied for application in flexible wearable devices due to their outstanding pressure-sensitive characteristics. In addition to the outstanding electrical performance, environmental friendliness, breathability, and wearable comfortability also deserve more attention. Here, a biodegradable, breathable multilayer pressure sensor based piezoresistive effect is presented. This pressure sensor is designed with all biodegradable materials, which show excellent biodegradability and breathability with a three-dimensional porous hierarchical structure. Moreover, due to the multilayer structure, the contact area of the pressure sensitive layers is greatly increased and the loading pressure can be distributed to each layer, so the pressure sensor shows excellent pressuresensitive characteristics over a wide pressure sensing range (0.03-11.60 kPa) with a high sensitivity (6.33 kPa −1 ). Furthermore, the sensor is used as a human health monitoring equipment to monitor the human physiological signals and main joint movements, as well as be developed to detect different levels of pressure and further integrated into arrays for pressure imaging and a flexible musical keyboard. Considering the simple manufacturing process, the low cost, and the excellent performance, leaf vein-based pressure sensors provide a good concept for environmentally friendly wearable devices.