“FLIPSY”—A New Solvent-Suppression Sequence for Nonexchanging Solutes Offering Improved Integral Accuracy Relative to 1D NOESY

LC–NMR coupling technology: recent advancements and applications in natural products analysis

“…and a Bischoff Lambda 1010 UV detector (Bischoff Chromatography, Leonberg, Germany) operating at 254 nm. The capillary column was self-packed with Bischoff ProntoSil EuroBond C 18 The chromatographic separation (Fig. 1) revealed the presence of three main peaks which, according to their retention times and UV data, could be attributed to rosmarinic acid, carnosic acid and carnosol.…”

Purge NMR: Effective and easy solvent suppression

“…2B) and superior suppression and baseline properties in comparison to the commonly employed 3-9-19 WATERGATE [4] experiment ( Fig 2C). We tested numerous additional solvent suppression approaches including WET [2], NOESY presaturation [8], FLIPSY [8], excitation sculpting [5], and excitation sculpting using a W5 sequence [9]. In all but the last case we could not achieve the suppression to match PURGE.…”

T1 relaxation measurement with solvent suppression

“…Thus, the chosen sample allowed for the examination if solvent saturation introduces any artifacts or inherent inaccuracies in the T 1 measurements. While there are certainly many more solvent suppression techniques reported in the literature, [1,3,4,13,14] the pulse sequences described in the Experimental Section were conceived on an exemplary basis to inspect the effects of three main elements commonly used in solvent suppression: saturation, selective pulses (soft or composite) and gradient filters. Furthermore, the examined solvent suppression pulse sequences cover a broad range of complexities with associated hardware requirements, i.e.…”