With the increase of vehicle ownership and the rapid growth of urban traffic, the problem of congestion in the off-ramp area of the main expressway has become the main factor restricting overall section efficiency and inducing traffic accidents. This paper focuses on the problem of group collaborative lane-changing behaviors of off-ramp vehicles and through vehicles in off-ramp areas and proposes four kinds of vehicle group collaborative strategies based on different road space balance conditions. According to a three-lane expressway scene, a VISSIM-based simulation model is built and the optimization scheme is simulated and evaluated. The simulation results show that with the increase of traffic flow in off-ramp areas, a flow-balance strategy for downstream lanes where off-ramp vehicles merge with the outside lane in advance is more advantageous. When vehicles are leaving the main road, if traffic flow is heavy, the flow-balance strategy for lanes where off-ramp vehicles merge with the outside lane in advance (for example, the proportion of off-ramp vehicles in three lanes is 0 : 0 : 1) is better; otherwise, when the traffic flow on the main road is relatively small, the flow-balance strategy for lanes where off-ramp vehicles are distributed in lanes with different ratios (e.g., 1 : 3 : 6) is better. What is more, for future traffic management in connected vehicle environments, it can be concluded that collaborative vehicle lane-changing strategies with different traffic flow states can help to enhance traffic efficiency.