Flow-injection chemiluminometric determination of some phenothiazines in dosage forms and biological fluids

Aly, Fatma A.; Alarfaj, Nawal A.; Al–Warthan, Abdulrahman

doi:10.1016/s0003-2670(97)00622-3

Cited by 54 publications

(24 citation statements)

References 12 publications

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“…The reproducibility, selectivity and rapidity in signal detection of CL analysis can be highly improved by combination with FI technique [13][14][15][16][17].…”

Section: Resultsmentioning

confidence: 99%

Flow-injection chemiluminescent determination of cefprozil using Tris (2,2′-bipyridyl) ruthenium (II)-permanganate system

Alarfaj

El-Razeq

2006

Journal of Pharmaceutical and Biomedical Analysis

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“…The reproducibility, selectivity and rapidity in signal detection of CL analysis can be highly improved by combination with FI technique [13][14][15][16][17].…”

Section: Resultsmentioning

confidence: 99%

Flow-injection chemiluminescent determination of cefprozil using Tris (2,2′-bipyridyl) ruthenium (II)-permanganate system

Alarfaj

El-Razeq

2006

Journal of Pharmaceutical and Biomedical Analysis

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“…Especially prominent among the sensitizers used are quinine sulphate, which has been used to determine tiopronin 73 and penicillamine, 74 and rhodamines 6G and B, employed in the determination of captopril, 75 hydrochlorothiazide, 76 folic acid 77 and phenothiazines. 78 The determination of tiopronin 79 is carried out in the presence of two sensitizers (quinine sulphate and rhodamine 6G). On the other hand, most determinations involving Ce(IV) as the oxidant are of the indirect type.…”

Section: Speci®c Chemiluminescent Systemsmentioning

confidence: 99%

Flow‐chemiluminescence: a growing modality of pharmaceutical analysis

2001

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“…Different FIA-CL methods have been reported based on direct oxidation [73,74], sensitized CL [75,76], indirect CL [77], and enhanced CL [78] for the determination of phenothiazines. These CL reactions were tested by employing our homemade CE-CL instrument in order to select the most sensitive one.…”

Section: Selection Of the CL Reactionmentioning

confidence: 99%

Determination of phenothiazines in pharmaceutical formulations and human urine using capillary electrophoresis with chemiluminescence detection

et al. 2006

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A CE instrument coupled with chemiluminescence (CL) detection was designed for the determination of promethazine hydrochloride (PTH) and promazine hydrochloride (PMH) in real samples. An important enhancement of the CL emission of luminol with potassium ferricyanide was observed in the presence of these phenothiazines; so this system was selected for their detection after CE separation. Parameters affecting the electrophoretic separation were optimized in a univariate way, while those affecting CL detection were optimized by means of a multivariate approach based on the use of experimental designs. Chemometrics was also employed for the study of the robustness of the factors influencing the postcolumn CL detection. The method allows the separation of the phenothiazines in less than 4 min, achieving LODs of 80 ng/mL for PMH and 334 ng/mL for PTH, using sample injection by gravity. Electrokinetic injection was used to obtain lower LODs for the determination of the compounds in biological samples. The applicability of the CE-CL method was illustrated in the determination of PTH in pharmaceutical formulations and in the analysis of PMH in human urine, using a previous SPE procedure, achieving an LOD of 1 ng/mL and recoveries higher than 85%.

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Flow-injection chemiluminometric determination of some phenothiazines in dosage forms and biological fluids

Cited by 54 publications

References 12 publications

Flow-injection chemiluminescent determination of cefprozil using Tris (2,2′-bipyridyl) ruthenium (II)-permanganate system

Flow-injection chemiluminescent determination of cefprozil using Tris (2,2′-bipyridyl) ruthenium (II)-permanganate system

Flow‐chemiluminescence: a growing modality of pharmaceutical analysis

Determination of phenothiazines in pharmaceutical formulations and human urine using capillary electrophoresis with chemiluminescence detection

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