Flow-injection spectrophotometric determination of certain cephalosporins based on the formation of dyes

Metwally, Fadia H; Al–Warthan, Abdulrahman; Al-Tamimi, Salma A.

doi:10.1016/s0014-827x(01)01100-4

Cited by 23 publications

(16 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These methods include spectrophotometric methods, such as a flow-injection analysis after heating with iron(III) and o-phenanthroline, 1 a flow injection analysis after reacting the liberated sulfide with N,Ndiethyl-p-phenylenediamine and iron(III), 2 a reaction with potassium hexacyanoferrate, 3 molybdophosphoric acid, 4 chromotrope 2B and chromotrope 2R, 5 glucitol and sodium hydroxide, 6 NBS and NCS, 7 copper(II) and vanadium, 8 MBTH and 2,6-dichloroquinone-4-chlorimide, 9 oxidation with either iron (III) or cerium(IV), 10 mercurochrome, 11 ferric hydroxamate, 12 tetrachloroquinone, 13 p-benzoquinone and tetrachlorobenzoquinone, 14 ammonium molybdate, 5 ammonium vanadate, 16 sodium nitroprusside, 17 NBD-Cl 18 and tetrazolium salts. 19 The pharmacopoeial methods for analyzing the investigated cephalosporins are either chromatographic methods, 20,21 which are expensive, or titrimetric methods, 21 which are less sensitive.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Analytical Study for the Charge-Transfer Complexation of Certain Cephalosporins with Chloranilic Acid

et al. 2003

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Spectroscopic Analytical Study for the Charge-Transfer Complexation of Certain Cephalosporins with Chloranilic Acid

et al. 2003

View full text Add to dashboard Cite

“…This spectrum shows no absorption at 352 nm whereas the absorbance of the reagent solution (KIO 3 and KI in methanol) at 352 nm is about 0.02. The wavelengths of maximum absorption of the interaction coloured product of cefradine anhydrous with KIO 3 and KI are at 298 and 352 nm. It is obvious that at 298 nm there is background absorption from the drug itself and from the reagent blank (Figure 1).…”

Section: Absorption Spectramentioning

confidence: 95%

“…It has been suggested that water-soluble acidic compounds liberate iodine from a solution containing both KIO 3 and KI according to the reaction [27];…”

Section: Suggested Reaction Mechanismmentioning

confidence: 99%

See 1 more Smart Citation

Kinetic spectrophotometric determination of certain cephalosporins using iodate/iodide mixture

El-Shaboury

Mohamed²,

Saleh³

et al. 2010

View full text Add to dashboard Cite

A simple, precise and accurate kinetic spectrophotometric method for determination of cefradine anhydrous, cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous and cefixime in bulk and in pharmaceutical formulations has been developed. The method based on a kinetic investigation of the reaction of the free carboxylic acid group of the drug with a mixture of potassium iodate and potassium iodide at room temperature to form yellow coloured triiodide ions. The reaction was followed up spectrophotometrically by measuring the increase in absorbance at 352 nm as a function of time. The initial rate, fixed time, variable time and rate-constant methods were adopted for constructing the calibration curves but fixed time method has been found to be more applicable. The analytical performance of the method, in terms of accuracy and precision, was statistically validated; the results were satisfactory. The method has been successfully applied to the determination of the studied drugs in commercial pharmaceutical formulations. Statistical comparison of the results with a well established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision.

show abstract

“…The structural formula of this pharmaceutical compound is exhibited in scheme 1. This antibiotic drug has been analysed in pharmaceutical formulations and biological samples by various analytical methods such as spectrophotometry [12][13][14], high performance liquid chromatography (HPLC) [15,16], and electrochemical methods such as polarography and differential pulse voltammetry [17,18]. However, no literature data were found on the square wave voltammetry in general, or on the adsorptive stripping determination of this drug in particular.…”

Section: Introductionmentioning

confidence: 99%

A Study of Stripping Voltammetric Behaviour of Cefadroxil Antibiotic in the Presence of Cu (II) and its Determination in Pharmaceutical Formulation

Al-Ghamdi¹,

Alghamdi

Al-Omar

2009

Port. Electrochim. Acta

View full text Add to dashboard Cite

Square-wave voltammetry was used to explore the adsorption property of cefadroxil complex with copper ions on the hanging mercury drop electrode (HMDE). By employing the adsorptive stripping voltammetric approach, a sensitive electroanalytical method for the quantitative analysis of cefadroxil antibiotic was achieved. A welldeveloped voltammetric peak was obtained in pH 10 Britton-Robinson buffer (B-R buffer) at -650 mV. The cyclic voltammetric studies indicated that the reduction process was irreversible and primarily controlled by adsorption. An investigation of the variation of adsorptive voltammetric peak current with supporting electrolyte, pH, accumulation time, accumulation potential, scan rate, pulse amplitude, SW frequency, working electrode area and convection rate has resulted in the recognition of optimal experimental conditions for cefadroxil analysis. The studied electroanalytical signal showed a linear response for cefadroxil in the concentration range 6×10 -7 -2×10 -6 mol L -1 (r = 0.999). A limit of detection of 2×10 -9 mol L -1 with relative standard deviation of 2.783 RSD% and mean recovery of 99% was obtained. Possible interferences by several substances usually present in pharmaceutical formulation were also evaluated. The analytical quantification of cefadroxil in commercially available pharmaceutical formulation was performed and compared with data from HPLC technique.

show abstract

Flow-injection spectrophotometric determination of certain cephalosporins based on the formation of dyes

Cited by 23 publications

References 12 publications

Spectroscopic Analytical Study for the Charge-Transfer Complexation of Certain Cephalosporins with Chloranilic Acid

Spectroscopic Analytical Study for the Charge-Transfer Complexation of Certain Cephalosporins with Chloranilic Acid

Kinetic spectrophotometric determination of certain cephalosporins using iodate/iodide mixture

A Study of Stripping Voltammetric Behaviour of Cefadroxil Antibiotic in the Presence of Cu (II) and its Determination in Pharmaceutical Formulation

Contact Info

Product

Resources

About