Fluconazole Population Pharmacokinetics after Fosfluconazole Administration and Dosing Optimization in Extremely Low-Birth-Weight Infants

Tanzawa, Ayano; Saito, Jumpei; Shoji, Kensuke; Kojo, Yuka; Funaki, Takanori; Maruyama, Hidehiko; Isayama, Tetsuya; Ito, Yushi; Nakamura, Hidefumi; Yamatani, Akimasa

doi:10.1128/spectrum.01952-21

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…PK analysis of antimicrobial agents using population PK has been progressing in the Japanese pediatric field (Table 2). 32,[41][42][43][44][45][46][47][48][49] Shoji et al reported on the population PK analysis of meropenem in critically ill patients in the pediatric intensive care unit. 45 In this study, the authors reported that a longer time above MIC might result in a shorter time to resolution of fever and higher efficacy, and that patients with more severe inflammation (patients presenting with one or more systemic inflammatory response syndrome criteria) are more likely to have higher clearance of meropenem and may not achieve adequate time above MIC with standard doses.…”

Section: Application Of Population Pharmacokinetics In Research For C...mentioning

confidence: 99%

“…Furthermore, we conducted population PK analysis of fosfluconazole in extremely low birth weight infants and explored the optimal dosing in this population. 41 Recently, the information obtained by physiologically based pharmacokinetic modeling and population PK analysis information from real-world data are being utilized and some of them are reflected in the package inserts globally. [50][51][52][53] We have started collaboration with a pharmaceutical company for PK analysis utilizing academic clinical trial data and are currently discussing with Japanese regulators and industry representatives how we can utilize the real-world PK/PD information for regulatory purposes in Japan.…”

Section: Application Of Population Pharmacokinetics In Research For C...mentioning

confidence: 99%

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Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis

Shoji¹,

Saito²,

Nakamura

et al. 2022

Pediatric Infectious Disease Journal

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Pharmacologic knowledge is important for pediatricians conducting feasible pharmacokinetic or pharmacodynamic (PK/PD) studies or applying effective antimicrobial therapies in children. Because of the difficulties in conducting PK/PD studies in children, antimicrobial PK/PD data in children are still limited. To fill in the lack of knowledge, promotion of population PK/PD analysis, which allows us to handle sparse sampling data from individual patients, is important because it is considered a suitable methodology to conduct PK/PD studies in children with limited blood drug concentration data for PK/PD analysis. Population PK/PD analysis is also useful in the clinical setting to provide individualized optimal dosage for each patient with various conditions. Here we summarized the current aspects of pediatric PK/PD studies of antimicrobials in Japan from clinical and research perspectives, specifically focusing on the importance of population PK/PD analysis.

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Section: Application Of Population Pharmacokinetics In Research For C...mentioning

confidence: 99%

Section: Application Of Population Pharmacokinetics In Research For C...mentioning

confidence: 99%

Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis

Shoji¹,

Saito²,

Nakamura

et al. 2022

Pediatric Infectious Disease Journal

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Phosphorus Heterocycles and Their Biological Applications

Kumar,

Mukhopadhyay,

Bhagat

2024

ChemistrySelect

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Life of the living organism is based on phosphorous, and it is involved in almost all important biological and biochemical processes such as energy transfer, bone development and storing genetic information. Many of the therapeutic agents having C─P bond, isolated naturally as well and widely used in daily clinical practices are phosphorus‐containing drugs (e.g: phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, etc.) and growing further. The phosphorus heterocycles (PHs) integrate the merits of both phosphorus atom and heterocyclic scaffolds representing an important class of organophosphorus compounds, which are constantly drawing the attention among both industrial and scientific society as these compounds have shown varieties of related applications. Owing to its seminal biological importance PHs have inspired a whole generation of medicinal chemists to come up with novel scaffolds containing phosphorous atom. This review is focused mainly on the compilation of different classes of bioactive phosphorus containing heterocyclic skeletons (which includes phosphorus atom within the heterocyclic ring system or as substituted phosphorus atom attached with another heterocyclic ring system) having both therapeutic and other material chemistry applications since the year 2000 onwards barring their synthetic routes.

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Fluconazole Population Pharmacokinetics after Fosfluconazole Administration and Dosing Optimization in Extremely Low-Birth-Weight Infants

Cited by 2 publications

References 36 publications

Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis

Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis

Phosphorus Heterocycles and Their Biological Applications

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