Fluorescence-based immunosensor using three-dimensional CNT network structure for sensitive and reproducible detection of oral squamous cell carcinoma biomarker

Song, Chung Kil; Oh, Eunkyul; Kang, Min Sung; Shin, Bum Seok; Han, Sang Jae; Jung, Mingi; Lee, Eui‐Seok; Yoon, Soo Young; Sung, Myung Mo; Ng, Wee Keong; Cho, Nam‐Joon; Lee, Haiwon

doi:10.1016/j.aca.2018.04.025

Cited by 42 publications

(24 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sensor was used for the detection of a Cytokeratin-19 antigen (Cyfra 21-1) for the accurate diagnosis of oral squamous cell carcinoma (OSCC). The testing was carried out on 11 saliva samples (4 healthy and 7 from patients with OSCC), resulting in a limit of detection of 0.5 ng/mL and proving to be valid for clinical samples between 1 and 62.5 ng/mL [56].…”

Section: Discussionmentioning

confidence: 99%

Saliva, a Magic Biofluid Available for Multilevel Assessment and a Mirror of General Health—A Systematic Review

Ilea

Andrei²,

et al. 2019

Biosensors

View full text Add to dashboard Cite

Background: Saliva has been recently proposed as an alternative to classic biofluid analyses due to both availability and reliability regarding the evaluation of various biomarkers. Biosensors have been designed for the assessment of a wide spectrum of compounds, aiding in the screening, diagnosis, and monitoring of pathologies and treatment efficiency. This literature review aims to present the development in the biosensors research and their utility using salivary assessment. Methods: a comprehensive literature search has been conducted in the PubMed database, using the keywords “saliva” and “sensor”. A two-step paper selection algorithm was devised and applied. Results: The 49 papers selected for the present review focused on assessing the salivary biomarkers used in general diseases, oral pathologies, and pharmacology. The biosensors proved to be reliable tools for measuring the salivary levels of biochemical metabolic compounds such as glucose, proteinases and proteins, heavy metals and various chemical compounds, microorganisms, oncology markers, drugs, and neurotransmitters. Conclusions: Saliva is a biofluid with a significant clinical applicability for the evaluation and monitoring of a patient’s general health. Biosensors designed for assessing a wide range of salivary biomarkers are emerging as promising diagnostic or screening tools for improving the patients’ quality of life.

show abstract

Section: Discussionmentioning

confidence: 99%

Saliva, a Magic Biofluid Available for Multilevel Assessment and a Mirror of General Health—A Systematic Review

Ilea

Andrei²,

et al. 2019

Biosensors

View full text Add to dashboard Cite

show abstract

“…Various biomarkers or molecules can be detected in saliva, e.g., the cytokines interleukin-6 [70,71], interleukin-8 mRNA [72][73][74], interleukin-8 protein [72][73][74], cancer antigens [48] like carcinoembryonic antigen (CEA) [75,76], cancer antigen 125 (CA125) [76] and Her-2/Neu (C-erbB-2) [76,77], VEGF165 [78], TNFα [79], or cytokeratin-19 antigen (Cyfra 21-1) [80]. Moreover, lactate [48,54,58,[81][82][83][84], glucose [48,60,62,[85][86][87][88][89][90][91][92][93][94][95][96], or hormones [48,66], like cortisol [48,49,51,65,66,[97][98]…”

Section: Biosensors Operating In Salivamentioning

confidence: 99%

“…Additional to that, the detection of bacteria, viruses, and whole cells is possible, like Helicobacter pylori, Streptococcus sanguinis, Escherichia coli, Staphylococcus aureus, Chikungunya viruses [113][114][115][116][117][118] or different antibodies [48,66,114,119], e.g., HIV [48,66,120]. On the top, different drugs [49,51,80,121], like alcohol [53,66] and cocaine [66,122], as well as neurotransmitters [49,66,123] can be determined in saliva. The related diseases to the different biomolecules are cancer [51,70,[73][74][75][76][77]79,80,124], oral cancer [56,67,72,108,109], breast cancer [56,67], diabetes [49,60,67,85], and different cardiovascular diseases [68,…”

Section: Biosensors Operating In Salivamentioning

confidence: 99%

“…On the top, different drugs [49,51,80,121], like alcohol [53,66] and cocaine [66,122], as well as neurotransmitters [49,66,123] can be determined in saliva. The related diseases to the different biomolecules are cancer [51,70,[73][74][75][76][77]79,80,124], oral cancer [56,67,72,108,109], breast cancer [56,67], diabetes [49,60,67,85], and different cardiovascular diseases [68,108,109]. Moreover, diseases of the oral cavity like periodontal infections [56,67,125] or caries risk assessments [56] can be done.…”

Section: Biosensors Operating In Salivamentioning

confidence: 99%

“…The aptamers were immobilized on a gold electrode, followed by a blocking step with MCH to avoid unspecific binding. When ampicillin is bound by the methylene blue modified aptamer, the aptamer conformation changes; the measurement of the change was realized with the methods of alternating current voltammetry and square wave voltammetry [80].…”

Section: Biosensors Operating In Salivamentioning

confidence: 99%

See 2 more Smart Citations

Non-Invasive Electrochemical Biosensors Operating in Human Physiological Fluids

Falk

Psotta

Cirovic

et al. 2020

Sensors

View full text Add to dashboard Cite

Non-invasive healthcare technologies are an important part of research and development nowadays due to the low cost and convenience offered to both healthcare receivers and providers. This work overviews the recent advances in the field of non-invasive electrochemical biosensors operating in secreted human physiological fluids, viz. tears, sweat, saliva, and urine. Described electrochemical devices are based on different electrochemical techniques, viz. amperometry, coulometry, cyclic voltammetry, and impedance spectroscopy. Challenges that confront researchers in this exciting area and key requirements for biodevices are discussed. It is concluded that the field of non-invasive sensing of biomarkers in bodily fluid is highly convoluted. Nonetheless, if the drawbacks are appropriately addressed, and the pitfalls are adroitly circumvented, the approach will most certainly disrupt current clinical and self-monitoring practices.

show abstract

Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives

Kumar,

Ansari,

Basu

et al. 2024

Advanced Therapeutics

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) have emerged as revolutionary tools, offering innovative approaches to both diagnostic and therapeutic challenges spanning various cancer types. CNTs serve as imaging agents for early detection through MRI, CT, and fluorescence. They provide precise results with biosensors detecting cancer biomarkers for rapid diagnosis. In cancer therapy, CNTs excel in targeted drug delivery, enhancing bioavailability and minimizing off‐target effects. Their prowess in photothermal therapy selectively eradicates cancer cells. Despite challenges, ongoing research highlights CNT's transformative potential, promising enhanced precision, efficacy, and personalized cancer care across diverse malignancies in future clinical practice.

show abstract

Fluorescence-based immunosensor using three-dimensional CNT network structure for sensitive and reproducible detection of oral squamous cell carcinoma biomarker

Cited by 42 publications

References 37 publications

Saliva, a Magic Biofluid Available for Multilevel Assessment and a Mirror of General Health—A Systematic Review

Saliva, a Magic Biofluid Available for Multilevel Assessment and a Mirror of General Health—A Systematic Review

Non-Invasive Electrochemical Biosensors Operating in Human Physiological Fluids

Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives

Contact Info

Product

Resources

About