Fluorescence imaging agents in cancerology

Paganin-Gioanni, A.; Bellard, Elisabeth; Paquereau, Laurent; Ecochard, Vincent; Golzio, Muriel; Teissié, Justin

doi:10.2478/v10019-010-0031-y

Cited by 26 publications

(25 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of surgery on tumour growth were proposed in the late 50’s and were later confirmed by experimental studies (reviewed in 37). To improve surgical resection of tumours different fluorescence imaging agents can be used to detect and remove any residual tumour cells 38. It is important to remove all tumour cells because surgical resection of a tumour changes the microenvironment of the wound site and provides a tumour growth favourable microenvironment 4–6.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the tumourigenic and metastatic properties of SK-MEL28 melanoma cells surviving electrochemotherapy with bleomycin

Todorović¹,

Serša²,

Mlakar³

et al. 2012

Radiology and Oncology

View full text Add to dashboard Cite

BackgroundElectrochemotherapy is a local treatment combining chemotherapy and electroporation and is highly effective treatment approach for subcutaneous tumours of various histologies. Contrary to surgery and radiation, the effect of electrochemotherapy on metastatic potential of tumour cells has not been extensively studied. The aim of the study was to evaluate the effect of electrochemotherapy with bleomycin on the metastatic potential of human melanoma cells in vitro.Materials and methodsViable cells 48 hours after electrochemotherapy were tested for their ability to migrate and invade through Matrigel coated porous membrane. In addition, microarray analysis and quantitative Real-Time PCR were used to detect changes in gene expression after electrochemotherapy.ResultsCell migration and invasion were not changed in melanoma cells surviving electrochemotherapy. Interestingly, only a low number of tumourigenesis related genes was differentially expressed after electrochemotherapy.ConclusionsOur data suggest that metastatic potential of human melanoma cells is not affected by electrochemotherapy with bleomycin, confirming safe role of electrochemotherapy in the clinics.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of the tumourigenic and metastatic properties of SK-MEL28 melanoma cells surviving electrochemotherapy with bleomycin

Todorović¹,

Serša²,

Mlakar³

et al. 2012

Radiology and Oncology

View full text Add to dashboard Cite

show abstract

“…For in vivo imaging application, biological tissue has strong light scattering and autofluorescence 48 . Plasma also has massive absorption at 400–670 nm (hemoglobin) 49 . Therefore, near infrared (NIR) fluorophore is usually preferred for tissue imaging to avoid an overlap with tissue-autofluorescence and light scattering/absorption.…”

Section: Design Criteria Of Fluorescent Materials For Biomedical Amentioning

confidence: 99%

Design strategies for fluorescent biodegradable polymeric biomaterials

2013

View full text Add to dashboard Cite

The marriage of biodegradable polymer and fluorescent imaging has resulted in an important area of polymeric biomaterials: biodegradable fluorescent polymers. Researchers have put significant efforts on developing versatile fluorescent biomaterials due to their promising in biological/biomedical labeling, tracking, monitoring, imaging, and diagnostic applications, especially in drug delivery, tissue engineering, and cancer imaging applications. Biodegradable fluorescent polymers can function not only as implant biomaterials but also as imaging probes. Currently, there are two major classes of biodegradable polymers used as fluorescent materials. The first class is the combination of non-fluorescent biodegradable polymers and fluorescent agents such as organic dyes and quantum dots. Another class of polymers shows intrinsic photoluminescence as polymers by themselves carrying integral fluorescent chemical structures in or pendent to their polymer backbone, such as Green Fluorescent protein (GFP), and the recently developed biodegradable photoluminescent polymer (BPLP). Thus there is no need to conjugate or encapsulate additional fluorescent materials for the latter. In the present review, we will review the fluorescent biodegradable polymers with emphases on material fluorescence mechanism, design criteria for fluorescence, and their cutting-edge applications in biomedical engineering. We expect that this review will provide insightful discussion on the fluorescent biomaterial design and lead to innovations for the development of the next generation of fluorescent biomaterials and fluorescence-based biomedical technology.

show abstract

“…Specifically, the risk of spread by a biopsy is possible with superficial skin cancers such as melanoma. Therefore there is an increasing research interest in the development and application of new non-invasive methods for cancer diagnosis and detection at the early stage, such as fluorescence detection, radioisotopic scanning, magnetic resonance imaging, and positron emission tomography [1,2].…”

Section: Introductionmentioning

confidence: 99%