Fluorescent Dye Labeled Iron Oxide/Silica Core/Shell Nanoparticle as a Multimodal Imaging Probe

Abstract

Diameter and ζ-potential of the nanoparticles were measured, and TEM images demonstrated the mono-disperse nature of the particles. Quenching efficiency of the dyes on the surface was nearly 100% in the smallest nanoparticle, while almost no quenching effect was observed for the largest nanoparticle. In vitro cytotoxicity showed nearly 90% cell viability at 0.15 Fe mg/mL, a comparable concentration for clinical use. The tumor area was significantly darkened after the nanoparticle injection due to the high transverse relaxivity value of the nanoparticles. Fluorescence signal was affected by the particle size due to the distance-dependent quenching/dequenching behaviour.

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Imaging Strategies for Tissue Engineering Applications

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Groebke–Blackburn–Bienaymé multicomponent reaction: emerging chemistry for drug discovery

“…In view of this, several imidazo-annulated heterocycles bearing pyridines, pyrimidines, pyrazines, azines and diazines have emerged as versatile drug templates in broad areas of medicinal chemistry, ranging from antiviral, antibacterial, fungicidal, anti-ulcer and anti-inflammatory applications [37]. Fluorescent dyes have been widely used in the photovoltaic cells, optical sensors, light-emitting diodes (LEDs), fluorescent colourants and biological labels [86,87]. The latter are most often used to prepare various bioconjugates for immunochemistry and histochemistry via modification of antibodies, amino acids, peptides, oligonucleotides, nucleic acids, carbohydrates and other biological molecules [88][89][90].…”