Fluorescent hollow mesoporous carbon spheres for drug loading and tumor treatment through 980-nm laser and microwave co-irradiation

Gui, Xin; Chen, Yang; Zhang, Zheyu; Lei, Lulu; Zhu, Fangliang; Yang, Wenxuan; Guo, Yuhai; Chu, Maoquan

doi:10.1016/j.biomaterials.2020.120009

Cited by 35 publications

(16 citation statements)

References 65 publications

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“…The higher EE percentage of DOX is confirmed, and the results are given in Figure 7 a,b, and the loading capacity of DOX is given in Figure 7 c. The EE of DOX was highly attained on mesoporous carbon with different time intervals through hydrogen bonding and π–π stacking interactions of DOX with the surface basal plane of carbon layers. 51 …”

Section: Results and Discussionmentioning

confidence: 99%

Enhanced Doxorubicin Delivery in Folate-Overexpressed Breast Cancer Cells Using Mesoporous Carbon Nanospheres

et al. 2021

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Nanoparticle-based drug delivery reveals the safety and effectiveness and avoids premature drug release from the nanocarrier. These nanoparticles improve the bioavailability and stability of the drug against chemical and enzymatic degradation and facilitate targeted drug delivery. Herein, targeted folic acid-conjugated oxidized mesoporous carbon nanospheres (Ox-MPCNPs) were successfully fabricated and developed as antitumoral doxorubicin delivery for targeted breast cancer therapy. Fourier transform infrared spectroscopy studies confirmed that the doxorubicin was successfully bound on the Ox-MPCNP through hydrogen bonding and π–π interactions. X-ray diffraction studies showed that the synthesized doxorubicin-loaded Ox-MPCNP is semi-crystalline. The surface morphology of the synthesized doxorubicin-loaded Ox-MPCNP (DOX/Ox-MPCNP-Cys-PAsp-FA) was studied by scanning electron microscopy and high-resolution transmission electron microscopy, which demonstrates a sphere-shaped morphology. The cytotoxic effects of DOX/Ox-MPCNP-Cys-PAsp-FA were studied in MCF-7 breast cancer cells using the CytoTox96 assay kit. The study confirmed the cytotoxic effects of the synthesized nanospheres in vitro . Moreover, DOX/Ox-MPCNP-Cys-PAsp-FA-treated cells displayed efficient cell apoptosis and cell death in flow cytometry analysis. The mitochondrial fragmentation and nucleus damages were further confirmed by fluorescence microscopy. Thus, the approach used to construct the DOX/Ox-MPCNP-Cys-PAsp-FA carrier provides excellent opportunities for the targeted treatment of breast cancer.

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Section: Results and Discussionmentioning

confidence: 99%

Enhanced Doxorubicin Delivery in Folate-Overexpressed Breast Cancer Cells Using Mesoporous Carbon Nanospheres

et al. 2021

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“…Importantly, when combined with 980 nm laser irradiation, it was found that microwaves could improve the photothermal effect produced by HMCS and check the growth of tumor cells. Carbon nanotubes (CNTs) are a carbon allotrope, which have the characteristics of resonance light luminescence, strong NIR optical absorption and Raman scattering, and can be used for cancer multi-modal imaging and treatment [200]. In addition, CNTs can also enhance the anti-tumor effects of chemotherapeutics by improving the accuracy and efficiency of drug delivery [201].…”

Section: Mesoporous Carbon Nps (Mcnps)mentioning

confidence: 99%

Optimization of Nanoparticles for Smart Drug Delivery: A Review

et al. 2021

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Nanoparticle delivery systems have good application prospects in the treatment of various diseases, especially in cancer treatment. The effect of drug delivery is regulated by the properties of nanoparticles. There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made. This review summarizes the optimization strategies of nanoparticles from three aspects—improving biocompatibility, increasing the targeting efficiency of nanoparticles, and improving the drug loading rate of nanoparticles—aiming to provide some theoretical reference for the subsequent drug delivery of nanoparticles.

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“…Alternatively, researchers seek out carbon-based material as PTAs, including carbon nanotubes, graphene, and graphene oxides. Carbon nanomaterials are widely investigated for their long-conjugated bands and strong NIR-light absorption. ,− Many transition metal-based PTAs, including Ag 2 S and CuS, also have been reported for the tumor PTT. Overall, inorganic PTAs have high PCE and excellent photothermal stability.…”

Section: Classification Of Ptasmentioning

confidence: 99%

Polymer-Based Nanomaterials for Noninvasive Cancer Photothermal Therapy

Zhang

et al. 2020

ACS Appl. Polym. Mater.

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Over the past decade, noninvasive photothermal therapy (PTT) has been intensively investigated for the treatment of tumors. In contrast to the traditional therapies, PTT has high tumor ablation efficiency and slight or no side effects, which are promising in medicine and clinical applications. In this review, we introduce the application of polymer-based nanomaterials for PTT of cancer and focus on the development profile, typical researches, and the latest research progress of the representative polymer photothermal agents (PTAs). We briefly summarize common PTAs involving inorganic materials and organic small molecules dyes and describe the polymer-based PTAs, including polyaniline (PANI), polypyrrole (PPy), polydopamine (PDA), donor−acceptor (D−A) structured polymer molecules, and poly(3,4ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS).Through this review, we can have an overall understanding of polymer photothermal materials in cancer photothermal therapy.

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Fluorescent hollow mesoporous carbon spheres for drug loading and tumor treatment through 980-nm laser and microwave co-irradiation

Cited by 35 publications

References 65 publications

Enhanced Doxorubicin Delivery in Folate-Overexpressed Breast Cancer Cells Using Mesoporous Carbon Nanospheres

Enhanced Doxorubicin Delivery in Folate-Overexpressed Breast Cancer Cells Using Mesoporous Carbon Nanospheres

Optimization of Nanoparticles for Smart Drug Delivery: A Review

Polymer-Based Nanomaterials for Noninvasive Cancer Photothermal Therapy

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