Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors

Haziza, Simon; Mohan, Nitin; Loe-Mie, Yann; Lepagnol-Bestel, Aude-Marie; Massou, Sophie; Adam, Marie-Pierre; Le, Xuan Loc; Viard, Julia; Plançon, Christine; Daudin, Rachel; Koebel, Pascale; Dorard, Emilie; Rose, Christiane; Hsieh, Feng-Jen; Wu, Chun‐Chieh; Potier, Brigitte; Hérault, Yann; Sala, Carlo; Corvin, Aiden; Allinquant, Bernadette; Chang, Huan‐Cheng; Treussart, François; Simonneau, Michel

doi:10.1038/nnano.2016.260

Cited by 124 publications

(155 citation statements)

References 34 publications

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“…Notably, this report by Haziza et al . is the very first nanoparticle-based platform used to enable direct measurement of intraneuronal transport in vivo [168]. The group was able to track the motion of FNDs inside neurons, both in vitro and in vivo to develop a high-throughput assay measuring intraneuronal transport.…”

Section: Bioimagingmentioning

confidence: 99%

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Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties. Their remarkable properties have established NDs as an invaluable regenerative medicine platform, with a broad range of clinically relevant applications ranging from targeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules in vitro and in vivo. This review introduces the synthesis techniques and the various routes of surface functionalization that allow for precise control over the properties of NDs. It also provides an in-depth overview of the current progress made towards the use of NDs in the fields of drug delivery, tissue engineering, and bioimaging. Their future outlook in regenerative medicine including the current clinical significance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed technologies from research platforms to clinical therapies will also be discussed.

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Section: Bioimagingmentioning

confidence: 99%

“…iii) An expanded view of the two FNDs labeled in part ii), displaying the trajectory of each particle (indicated by the yellow and green markings) over 10 seconds at several time periods. The scale bar represents 1 μm [168]. B) Single-particle tracking (SPT) of proteins in transmembrane signaling.…”

Section: Figurementioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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“…Inorganic devices in this context are typically made from semiconductor or metal materials, while organic ones are primarily carbon‐based and may be derived from biological sources. Organic devices have shown great promise as bioelectronics, and we refer the reader to a small selection of the numerous excellent articles regarding nanodiamonds, [ 22–26 ] carbon nanotubes, [ 27–29 ] and graphene‐based materials [ 15,30,31 ] as well as conjugated polymers [ 32 ] and biologically‐derived nanomaterials. [ 33,34 ]…”

Section: Introductionmentioning

confidence: 99%

Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Schaumann

Tian

2020

Small Methods

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systems have already yielded impressive results, such as a bionic hand with sensory feedback, [11] and a closed-loop optogenetic system that can modulate bladder function in rats. [12] These developments provide us with a helpful template for the future of nano-bioelectronics. In the coming years, we expect to see a proliferation of integrated devices and closed-loop systems that incorporate nanoelectronics in biological contexts.Nanoelectronics present us with a number of features that make them particularly desirable in biological research. Nanomaterials can possess unique optical, [13] electronic, [14,15] and magnetic [16,17] properties that only become evident at sufficiently small length scales. Moreover, nanoelectronics provide the opportunity to probe the coupling of electric phenomena and physiology from the scale of tissues and organs down to the scale of individual cells and organelles (Figure 1). [18][19][20][21] The ability of these materials to target such small structures opens the door to inquiries into the pathways for electrical transduction in biology at the scale of the pertinent molecules, and to leverage those to access therapeutic targets that would otherwise be unavailable.We draw a contrast here between inorganic nanobioelectronics, which are the focus of this Progress Report, and organic nano-bioelectronics, which are also a subject of intense research. Inorganic devices in this context are typically made from semiconductor or metal materials, while organic ones are primarily carbon-based and may be derived from biological sources. Organic devices have shown great promise as bioelectronics, and we refer the reader to a small selection of the numerous excellent articles regarding nanodiamonds, [22][23][24][25][26] carbon nanotubes, [27][28][29] and graphene-based materials [15,30,31] as well as conjugated polymers [32] and biologically-derived nanomaterials. [33,34] In broad terms, the advantages of inorganic nanomaterials are that they can adopt a wide array of precisely tunable architectures and functionalities, which can be achieved through numerous techniques during synthesis. [15,[35][36][37][38] Their disadvantages include potentially high costs of manufacture, particularly with respect to noble metal precursors, [36,39] and the possibility for accumulation without degradation in cells. [40,41] Organic nanomaterials tend to have good biocompatibility when functionalized appropriately. [23,26,32,42] They also integrate well with other bioelectronic tools, either as extensions to scaffolds [32] or as the scaffolds themselves, [33] and they can minimize negative cellular responses to mechanical mismatches between the cytoskeleton and the device. [32,33] Compared to inorganic The last several years have seen a large and increasing interest in scientific developments that combine methods and materials from nanotechnology with questions and applications in bioelectronics. This follows with a number of broader trends: the rapid increase in functionality for materials at the nanoscale; a gro...

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“…Nanodiamonds (ND) hosting such colour centres are promising for various biological 13 and quantum [14][15][16] technologies, thanks in part to their compatibility with biologically active tissue and with common surface modification techniques 13,17 . Furthermore, they have been employed for laser trapping techniques [18][19][20] and scanning tip microscopy [21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Top-down fabrication of high-uniformity nanodiamonds by self-assembled block copolymer masks

Zheng

Lienhard

Doerk

et al. 2019

Sci Rep

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Nanodiamonds hosting colour centres are a promising material platform for various quantum technologies. The fabrication of non-aggregated and uniformly-sized nanodiamonds with systematic integration of single quantum emitters has so far been lacking. Here, we present a top-down fabrication method to produce 30.0 ± 5.4 nm uniformly-sized single-crystal nanodiamonds by block copolymer self-assembled nanomask patterning together with directional and isotropic reactive ion etching. We show detected emission from bright single nitrogen vacancy centres hosted in the fabricated nanodiamonds. The lithographically precise patterning of large areas of diamond by self-assembled masks and their release into uniformly sized nanodiamonds open up new possibilities for quantum information processing and sensing.

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Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors

Cited by 124 publications

References 34 publications

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Top-down fabrication of high-uniformity nanodiamonds by self-assembled block copolymer masks

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